Antitumour activity and specificity as a function of substitutions in the lipophilic sector of helical lactoferrin-derived peptide

Journal of Peptide Science

Volumn 9, Issue 5, 2003, Pages 300-311

  Yang, Nannan ^a   Lejon, Tore ^a   Rekdal, Øystein ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Antimicrobial peptides; Lactoferrin; Lytic peptides; QSAR; Tumoricidal peptides; Tumour cell specificity

Indexed keywords

ALANINE; AROMATIC AMINO ACID; ISOLEUCINE; LACTOFERRIN; LYSINE; PEPTIDE DERIVATIVE; PHENYLALANINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DESIGN; DRUG SYNTHESIS; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; LIPOPHILICITY; LUNG FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROKARYOSIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; LACTOFERRIN; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN STRUCTURE, SECONDARY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STAPHYLOCOCCUS AUREUS;

BOVINAE; EUKARYOTA; PROKARYOTA;

EID: 0037603394     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/psc.457     Document Type: Article

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