Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer

Oncology Reports

Volumn 27, Issue 1, 2012, Pages 101-108

  Wu, Buchu ^a,b   Hu, Ke ^a   Li, Shu ^a   Zhu, Jing ^a   Gu, Liying ^a   Shen, Haoran ^a   Hambly, Brett D ^b   Bao, Shisan ^a,b   Di, Wen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Dihydroartiminisin; Metastasis; Ovarian cancer

Indexed keywords

BETA ACTIN; DIHYDROARTEMISININ; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; PHOSPHORYLATED FOCAL ADHESION KINASE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE INFILTRATION; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; ARTEMISININS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MATRIX METALLOPROTEINASE 2; MICE; MICE, NUDE; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84855273491     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1505     Document Type: Article

References (40)

1. Meshnick SR: Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol 32: 1655-1660, 2002.
2. O'Neill PM: Medicinal chemistry: a worthy adversary for malaria. Nature 430: 838-839, 2004.
3. Efferth T, Dunstan H, Sauerbrey A, Miyachi H and Chitambar CR: The anti-malarial artesunate is also active against cancer. Int J Oncol 18: 767-773, 2001.
4. Huang XJ, Ma ZQ, Zhang WP, Lu YB and Wei EQ: Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells. J Pharm Pharmacol 59: 849-856, 2007.
5. Nam W, Tak J, Ryu JK, et al.: Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells. Head Neck 29: 335-340, 2007. (Pubitemid 46623498)
6. Singh NP and Lai H: Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci 70: 49-56, 2001. (Pubitemid 33130042)
7. Chen T, Li M, Zhang R and Wang H: Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy. J Cell Mol Med 13: 1358-1370, 2009.
8. Bertone-Johnson ER: Epidemiology of ovarian cancer: a status report. Lancet 365: 101-102, 2005.
9. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
10. Shenhua X, Lijuan Q, Hanzhou N, et al.: Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization. J Exp Clin Cancer Res 18: 233-239, 1999. (Pubitemid 29359410)
11. Dai L, Gu L, Ding C, Qiu L and Di W: TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression. Cancer Lett 283: 159-167, 2009.
12. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
13. Zhang J and Wang B: Arsenic trioxide (As(2)O(3)) inhibits peritoneal invasion of ovarian carcinoma cells in vitro and in vivo. Gynecol Oncol 103: 199-206, 2006. (Pubitemid 44374690)
14. Zhang S, Lin QD and Di W: Suppression of human ovarian carcinoma metastasis by the metastasis-suppressor gene, BRMS1. Int J Gynecol Cancer 16: 522-531, 2006.
15. Xu Y, Hunt NH and Bao S: The role of granulocyte macrophage-colony- stimulating factor in acute intestinal inflammation. Cell Res 18: 1220-1229, 2008.
16. Yang JZ, Ho AL, Ajonuma LC, et al.: Differential effects of Matrigel and its components on functional activity of CFTR and ENaC in mouse endometrial epithelial cells. Cell Biol Int 27: 543-548, 2003. (Pubitemid 36808672)
17. Schlaepfer DD, Mitra SK and Ilic D: Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 1692: 77-102, 2004. (Pubitemid 38898737)
18. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG and Frame MC: The role of focal-adhesion kinase in cancer: a new therapeutic opportunity. Nat Rev Cancer 5: 505-515, 2005. (Pubitemid 40942827)
19. Hoekstra R, Eskens FA and Verweij J: Matrix metalloproteinase inhibitors: current developments and future perspectives. Oncologist 6: 415-427, 2001. (Pubitemid 33022212)
20. Lengyel E, Schmalfeldt B, Konik E, et al.: Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer. Gynecol Oncol 82: 291-298, 2001. (Pubitemid 32730606)
21. Cattaruzza S and Perris R: Proteoglycan control of cell movement during wound healing and cancer spreading. Matrix Biol 24: 400-417, 2005. (Pubitemid 41765019)
22. Buommino E, Baroni A, Canozo N, et al.: Artemisinin reduces human melanoma cell migration by down-regulating alpha V beta 3 integrin and reducing metalloproteinase 2 production. Invest New Drugs 27: 412-418, 2009.
23. Hou J, Wang D, Zhang R and Wang H: Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 14: 5519-5530, 2008.
24. Jiao Y, Ge CM, Meng QH, Cao JP, Tong J and Fan SJ: Dihydroartemisinin is an inhibitor of ovarian cancer cell growth. Acta Pharmacol Sin 28: 1045-1056, 2007. (Pubitemid 47020494)
25. Lai H and Singh NP: Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat. Cancer Lett 231: 43-48, 2006. (Pubitemid 41779452)
26. Hwang YP, Yun HJ, Kim HG, Han EH, Lee GW and Jeong HG: Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms. Biochem Pharmacol 79: 1714-1726, 2010.
27. Tan XJ, Lang JH, Plouet J, Wu M and Shen K: [Effects of dihydroartiminisin on the adhesion, migration, and invasion of epithelial ovarian cancer cells]. Zhonghua Yi Xue Za Zhi 88: 2642-2646, 2008.
28. Disbrow GL, Baege AC, Kierpiec KA, et al.: Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res 65: 10854-10861, 2005. (Pubitemid 41713353)
29. Zhou HJ, Zhang JL, Li A, Wang Z and Lou XE: Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomas in vivo and inhibits murine Lewis lung carcinoma cell line growth in vitro. Cancer Chemother Pharmacol 66: 21-29, 2010.
30. Wang SJ, Gao Y, Chen H, et al.: Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett 293: 99-108, 2010.
31. Parsons JT, Martin KH, Slack JK, Taylor JM and Weed SA: Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19: 5606-5613, 2000.
32. Provenzano PP and Keely PJ: The role of focal adhesion kinase in tumor initiation and progression. Cell Adh Migr 3: 347-350, 2009.
33. Anfosso L, Efferth T, Albini A and Pfeffer U: Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins. Pharmacogenomics J 6: 269-278, 2006. (Pubitemid 44137954)
34. Weidner N, Folkman J, Pozza F, et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887, 1992. (Pubitemid 23004615)
35. Brem S, Cotran R and Folkman J: Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst 48: 347-356, 1972.
36. Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
37. Coussens LM and Werb Z: Inflammation and cancer. Nature 420: 860-867, 2002. (Pubitemid 36019639)
38. Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612, 2006. (Pubitemid 43165918)
39. Jonjic N, Peri G, Bernasconi S, et al.: Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells. J Exp Med 176: 1165-1174, 1992.
40. Wang E, Ngalame Y, Panelli MC, et al.: Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. Clin Cancer Res 11: 113-122, 2005.