Subchronic pulmonary pathology, iron overload, and transcriptional activity after libby amphibole exposure in rat models of cardiovascular disease

Environmental Health Perspectives

Volumn 120, Issue 1, 2012, Pages 85-91

  Shannahan, Jonathan H ^a   Nyska, Abraham ^b   Cesta, Mark ^c   Schladweiler, Mette C J ^d   Vallant, Beena D ^e   Ward, William O ^f   Ghio, Andrew J ^g   Gavett, Stephen H ^d   Kodavanti, Urmila P ^d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d Genomics Core   (United States)

^e Environmental Public Health Division Genomics Core   (United States)

^f U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^g U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cardiovascular disease; Iron overload; Lilly amphibole; Pulmonary pathology

Indexed keywords

AMPHIBOLE; COLLAGEN; CXCL14 CHEMOKINE; CYTOKERATIN 10; CYTOKERATIN 14; CYTOKERATIN 19; CYTOKINE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; PROTEIN P53; RANTES; SURFACTANT PROTEIN A; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CARDIOVASCULAR DISEASE; CLARA CELL; CONTROLLED STUDY; DISEASE MODEL; ENVIRONMENTAL EXPOSURE; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; HYPERPLASIA; INFLAMMATION; INTERNALIZATION; IRON OVERLOAD; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; LUNG LAVAGE; LUNG LESION; LUNG PARENCHYMA; MALE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE HEART FAILURE RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; SUBCHRONIC LUNG INJURY; TUMOR SUPPRESSOR GENE;

ANIMALIA; RATTUS;

EID: 84855223891     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103990     Document Type: Article

References (30)

1. Abdalla M, Fawzi M, Al-Maloul S, El-Banna N, Tayyem F, Ahmad M. 2011. Increased oxidative stress and iron overload in Jordanian beta-thalassemic children. Hemoglobin 35:67-79.
2. Adiseshaiah P, Vaz M, Machireddy N, Kalvakolanu V, Reddy S. 2008. A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion. J Cell Physiol 216:405-412.
3. Bernstein D, Chevalier J, Smith P. 2003. Comparison of Calidria chrysotile asbestos to pure tremolite: inhalation biopersistence and histopathology following short-term exposure. Inhal Toxicol 15:1387-1419.
4. Bernstein D, Rogers R, Sepulveda R, Donaldson K, Schuler D, Gaering S, et al. 2010. The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short-term inhalation exposure: interim results. Inhal Toxicol 22:937-962.
5. Brody A, Hill L, Adkins B, O'Connor R. 1981. Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am Rev Respir Dis 123:670-679.
6. Duncan K, Ghio A, Dailey L, Bern A, Gibbs-Flournoy E, Padilla-Carlin D, et al. 2010. Effect of size-fractionation on the toxicity of amosite and Libby amphibole asbestos. Toxicol Sci 118:420-434.
7. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
8. Ghiazza M, Scherbart A, Fenoglio I, Grendene F, Turci F, Martra G, et al. 2011. Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24:99-110.
9. Ghio A, Churg A, Roggli V. 2004. Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. Toxicol Pathol 32:643-649.
10. Ghio A, Funkhouser W, Pugh B, Winters S, Stonehuerner J, Mahar A, et al. 2006. Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. Toxicol Pathol 34:723-729.
11. Ghio A, Tan R, Ghio K, Fattman C, Oury T. 2009. Iron accumulation and expression of iron-related proteins following murine exposure to crocidolite. J Environ Pathol Toxicol Oncol 28:153-162.
12. Han H, Du B, Pan X, Liu J, Zhao Q, Lian X, et al. 2010. CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. Mol Cancer Res 8:1477-1488.
13. Hardy J, Aust A. 1995. The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks. Carcinogenesis 16:319-325.
14. Huang DW, Sherman BT, Lempicki RA. 2009a. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37(1):1-13.
15. Huang DW, Sherman BT, Lempicki RA. 2009b. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nature Protoc 4(1):44-57.
16. Kruszewski M. 2004. The role of labile iron pool in cardiovascular diseases. Acta Biochim Pol 51:471-480.
17. Kukulj S, Jaganjac M, Boranic M, Krizanac S, Santic Z, Poljak-Blazi M. 2010. Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer. Med Oncol 27:268-277.
18. Leckie B. 2001. Polymorphisms of the renin gene promoter in spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol 28:60-63.
19. McIntire M, Santagata S, Ligon K, Chirieac L. 2010. Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung. Am J Transl Res 2:309-315.
20. Moolgavkar S, Turim J, Alexander D, Lau E, Cushing C. 2010. Potency factors for risk assessment at Libby, Montana. Risk Anal 30:1240-1248.
21. Morris G, Notwick A, David O, Fermin C, Brody A, Friedman M. 2004. Development of lung tumors in mutant p53-expressing mice after inhalation exposure to asbestos. Chest 125:85S-86S.
22. Remmers E, Goldmuntz E, Zha H, Crofford L, Cash J, Mathern P, et al. 1993. Linkage map of seven polymorphic markers on rat chromosome 18. Mamm Genome 4(5):265-270.
23. Robledo R, Buder-Hoffmann S, Cummins A, Walsh E, Taatjes D, Mossman B. 2000. Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice. Am J Pathol 156:1307-1316.
24. Sen S, Roy M, Chakraborti A. 2011. Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. J Pharm Pharmacol 63:287-296.
25. Shannahan J, Ghio A, Schladweiler M, McGee J, Richards J, Gavett S, Kodavanit U. 2011a. The role of iron in Libby amphibole-induced acute lung injury and inflammation. Inhal Toxicol 23:313-323.
26. Shannahan J, Schladweiler M, Padilla-Carlin D, Nyska A, Richards J, Ghio A, et al. 2011b. The role of cardiovascular disease-associated iron overload in Libby amphibole-induced acute Sullivan pulmonary injury and inflammation. Inhal Toxicol 23:129-141.
27. Shannahan J, Schladweiler M, Richards J, Ledbetter A, Ghio A, Kodavanti U. 2010. Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease. J Toxicol Environ Health A 73:641-656.
28. Toyokuni S. 2011. Mysterious link between iron overload and CDKN2A/2B. J Clin Biochem Nutr 48:46-49.
29. Tsuzuki T, Ninomiya H, Natori Y, Ishikawa Y. 2008. Coalescent pleural malignant mesothelioma and adenocarcinoma of the lung, involving only minor asbestos exposure. Pathol Int 58:451-455.
30. Yao H, Rahman I. 2011. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol 254:72-85.