The role of cardiovascular disease-associated iron overload in Libby amphibole-induced acute pulmonary injury and inflammation

Inhalation Toxicology

Volumn 23, Issue 3, 2011, Pages 129-141

  Shannahan, Jonathan ^a   Schladweiler, Mette ^b   Padilla Carlin, Danielle ^a   Nyska, Abraham ^c   Richards, Judy ^b   Ghio, Andrew ^b   Gavett, Stephen ^b   Kodavanti, Urmila ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Inflammation; Iron; Libby Amphibole

Indexed keywords

AMPHIBOLE; ASCORBIC ACID; FERRITIN; FERRITIN HEAVY CHAIN; FERRITIN LIGHT CHAIN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HEME OXYGENASE 1; IRON; LIBBY AMPHIBOLE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; N ACETYL BETA GLUCOSAMINIDASE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; ENZYME ACTIVATION; EPITHELIUM HYPERPLASIA; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IRON METABOLISM; IRON OVERLOAD; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG GRANULOMA; LUNG LAVAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE HEART FAILURE RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; TISSUE LEVEL; WISTAR KYOTO RAT;

ANIMALS; ASBESTOS, AMPHIBOLE; ASBESTOSIS; ASCORBIC ACID; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CARDIOVASCULAR DISEASES; CHEMOKINE CXCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRITINS; GENE EXPRESSION REGULATION; IRON OVERLOAD; LUNG; MALE; NEUTROPHIL INFILTRATION; NEUTROPHILS; OXIDATIVE STRESS; PARTICULATE MATTER; PNEUMONIA; RATS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

RATTUS;

EID: 79952587188     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.551850     Document Type: Article

References (45)

1. Adamson IY, Bakowska J. 2001. KGF and HGF are growth factors for mesothelial cells in pleural lavage fuid after intratracheal asbestos. Exp Lung Res 27:605-616. (Pubitemid 32928294)
2. Anderson GJ, Vulpe CD. 2009. Mammalian iron transport. Cell Mol Life Sci 66:3241-3261.
3. Anderson ME. 1985. Determination of glutathione and glutathione disulfde in biological samples. Meth Enzymol 113:548-555. (Pubitemid 16195830)
4. Driscoll KE, Carter JM, Howard BW, Hassenbein D, Janssen YM, Mossman BT. 1998. Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants. Environ Health Perspect 106(Suppl 5):1171-1174. (Pubitemid 28554523)
5. Dorger M, Allmeling AM, Kiefmann R, Munzing S, Messmer K, Krombach F. 2002. Early infammatory response to asbestos exposure in rat and hamster lungs: Role of inducible nitric oxide synthase. Toxicol Appl Pharmacol 181:93-105. (Pubitemid 34625940)
6. Dostert C, Pétrilli V Van Bruggen R, Steele C, Mossman BT, Tschopp J. 2008. Innate immune activation through Nalp3 infammasome sensing of asbestos and silica. Science 320:674-677. (Pubitemid 351928351)
7. Duncan KE, Ghio AJ, Dailey LA, Bern AM, Gibbs-Flournoy EA, Padilla-Carlin DJ, Roggli VL, Devlin RB. 2010. Efect of size fractionation on the toxicity of amosite and Libby amphibole asbestos. Toxicol Sci 118:420-434.
8. Ellervik C, Tybjaerg-Hansen A, Appleyard M, Ibsen H, Nordestgaard BG 2010. Haemochromatosis genotype and iron overload: association with hypertension and left ventricular hypertrophy. J Intern Med 268:252-264.
9. Fattman CL, Tan RJ, Tobolewski JM, Oury TD. 2006. Increased sensitivity to asbestos-induced lung injury in mice lacking extracellular superoxide dismutase. Free Radic Biol Med 40:601-607. (Pubitemid 43170811)
10. Gazzano E, Turci F, Foresti E, Putzu MG, Aldieri E, Silvagno F, Lesci IG, Tomatis M, Riganti C, Romano C, Fubini B, Roveri N, Ghigo D. 2007a. Iron-loaded synthetic chrysotile: a new model solid for studying the role of iron in asbestos toxicity. Chem Res Toxicol 20:380-387. (Pubitemid 46548684)
11. Ghio AJ, Carter JD, Richards JH, Brighton LE, Lay JC, Devlin RB. 1998. Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle. Am J Physiol 274:L396-L403.
12. Ghio AJ, Roggli VL, Richards JH, Crissman KM, Stonehuerner JD, Piantadosi CA. 2003. Oxalate deposition on asbestos bodies. Hum Pathol 34:737-742. (Pubitemid 37040607)
13. Ghio AJ, Churg A, Roggli VL. 2004. Ferruginous bodies: implications in the mechanism of fber and particle toxicity. Toxicol Pathol 32:643-649. (Pubitemid 39491934)
14. Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, Roggli VL. 2006. Pulmonary fbrosis and ferruginous bodies associated with exposure to synthetic fbers. Toxicol Pathol 34:723-729. (Pubitemid 44665524)
15. Ghio AJ, Stonehuerner J, Richards J, Devlin RB. 2008. Iron homeostasis in the lung following asbestos exposure. Antioxid Redox Signal 10:371-377.
16. Governa M, Amati M, Fontana S, Visona I, Botta GC, Mollo F, Bellis D, Bo P. 1999. Role of iron in asbestos-body-induced oxidant radical generation. J Toxicol Environ Health Part A 58:279-287. (Pubitemid 29535215)
17. Gozzelino R, Jeney V, Soares MP. 2010. Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50:323-354.
18. Hill GD, Mangum JB, Moss OR, Everitt JI. 2003. Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. Exp Lung Res 29:277-290. (Pubitemid 36851254)
19. Hirano S, Ono M, Aimoto A. 1988. Functional and biochemical efects on rat lung following instillation of crocidolite and chrysotile asbestos. J Toxicol Environ Health 24:27-39.
20. Kamp DW, Israbian VA, Preusen SE, Zhang CX, Weitzman SA. 1995a. Asbestos causes DNA strand breaks in cultured pulmonary epithelial cells: role of iron-catalyzed free radicals. Am J Physiol 268:L471-L480.
21. Kamp DW, Israbian VA, Yeldandi AV, Panos RJ, Gracefa P, Weitzman SA. 1995b. Phytic acid, an iron chelator, attenuates pulmonary infammation and fbrosis in rats after intratracheal instillation of asbestos. Toxicol Pathol 23:689-695. (Pubitemid 26021843)
22. Kamp DW, Weitzman SA. 1999. Te molecular basis of asbestos induced lung injury. Torax 54:638-652. (Pubitemid 29296687)
23. Kapturczak MH, Wasserfall C, Brusko T, Campbell-Tompson M, Ellis TM, Atkinson MA, Agarwal A. 2004. Heme oxygenase-1 modulates early infammatory responses: evidence from the heme oxygenase-1-defcient mouse. Am J Pathol 165:1045-1053. (Pubitemid 39129309)
24. Kibel A, Belovari T, Drenjancevic-Peric I. 2008. Te role of transferrin in atherosclerosis. Med Hypotheses 70:793-797.
25. Koorts AM, Viljoen M. 2007. Ferritin and ferritin isoforms I: Structure-function relationships, synthesis, degradation and secretion. Arch Physiol Biochem 113:30-54. (Pubitemid 46825687)
26. Kruszewski M. 2004. Te role of labile iron pool in cardiovascular diseases. Acta Biochim Pol 51:471-480. (Pubitemid 38969308)
27. Lowers HA, Bern AM. 2009. Particle Size Characterization of Water-Elutriated Libby Amphibole 2000 and RTI International Amosite. USGS Open File Report 2009-1242.
28. Meeker GP, Bern AM, Brownfeld IK, Lowers HA, Sutley SJ, Hoefen TM, Vance JS. 2003. Te composition and morphology of amphiboles from the Rainy Creek Complex, near Libby, Montana. American Mineralogist 88:1955-1969. (Pubitemid 38098172)
29. Nyska A, Murphy E, Foley J F, Collins BJ, Petranka J, Howden R, Hanlon P, Dunnick JK. 2005. Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and cafeine. Toxicol Sci 83:388-396. (Pubitemid 40227909)
30. Peipins LA, Lewin M, Campolucci S, Lybarger JA, Miller A, Middleton D, Weis C, Spence M, Black B, Kapil V 2003. Radiographic abnormalities and exposure to asbestos-contaminated vermiculite in the community of Libby, Montana, USA. Environ Health Perspect 111:1753-1759. (Pubitemid 37407936)
31. Poss KD, Tonegawa S. 1997. Reduced stress defense in heme oxygenase 1-defcient cells. Proc Natl Acad Sci USA 94:10925-10930. (Pubitemid 27430837)
32. Putnam EA, Smartt A, Groves A, Schwanke C, Brezinski M, Pershouse MA. 2008. Gene expression changes after exposure to six-mix in a mouse model. J Immunotoxicol 5:139-144. (Pubitemid 351882421)
33. Raval CM, Lee PJ. 2010. Heme oxygenase-1 in lung disease. Curr Drug Targets 11:1532-1540.
34. Sabo-Attwood T, Ramos-Nino M, Bond J, Butnor KJ, Heintz N, Gruber AD, Steele C, Taatjes DJ, Vacek P, Mossman BT. 2005. Gene expression profles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fbrogenesis. Am J Pathol 167:1243-1256. (Pubitemid 41541411)
35. Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB. 2009. Biopersistence and potential adverse health impacts of fbrous nanomaterials: what have we learned from asbestos? Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:511-529.
36. Shackelford C, Long G, Wolf J, Okerberg C, Herbert R. 2002. Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies. Toxicol Pathol 30:93-96. (Pubitemid 34194564)
37. Shannahan JH, Schladweiler MC, Richards JH, Ledbetter AD, Ghio AJ, Kodavanti UP. 2010. Pulmonary oxidative stress, infammation, and dysregulated iron homeostasis in rat models of cardiovascular disease. J Toxicol Environ Health Part A 73:641-656.
38. Shannahan JH, Ghio AJ, Schladweiler MC, McGee JK, Richards JH, Gavett SH, Kodavanti UP. 2011. Te role of iron in Libby amphibole-induced toxicity. Inhal Toxicol.
39. Smartt AM, Brezinski M, Trapkus M, Gardner D, Putnam EA. 2010. Collagen accumulation over time in the murine lung after exposure to crocidolite asbestos or Libby amphibole. Environ Toxicol 25: 68-76.
40. Sullivan PA. 2007. Vermiculite, respiratory disease, and asbestos exposure in Libby, Montana: update of a cohort mortality study. Environ Health Perspect 115:579-585. (Pubitemid 46585530)
41. US EPA. 2010. Particle size distribution data for Libby amphibole structures observed in air at the Libby asbestos Superfund site. Superfund Records Center, US EPA Region 8, Denver, CO.
42. Wallenborn JG, Kovalcik KD, McGee JK, Landis MS, Kodavanti UP. 2009. Systemic translocation of (70)zinc: kinetics following intratracheal instillation in rats. Toxicol Appl Pharmacol 234:25-32.
43. Webber JS, Blake DJ, Ward TJ, Pfau JC 2008. Separation and characterization of respirable amphibole fbers from Libby, Montana. Inhal Toxicol 20:733-740. (Pubitemid 351882938)
44. Xie XM, Cao X, Chen MF, Zhou YC, Chen XB, Jiang HY 2008. Efect of chronic iron overload on atherosclerosis lesion in apolipoprotein E knockout mice. Zhong Nan Da Xue Xue Bao.Yi Xue Ban 33: 57-62.
45. Yasuda T, Funakubo A, Fukui Y 2002. An investigation of blood damage induced by static pressure during shear-rate conditions. Artif Organs 26:27-31. (Pubitemid 34226946)