The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer

Molecular Medicine Reports

Volumn 5, Issue 1, 2012, Pages 12-16

  Kim, Yoon Jae ^a   Park, Soo Bin ^b   Park, Jeong Youp ^b   Park, Seung Woo ^b   Chung, Jae Bock ^b   Song, Si Young ^b   Bang, Seungmin ^b  

^a Gachon University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Extrahepatic biliary tract cancer; Gli1 protein; SMO protein; Sonic hedgehog protein

Indexed keywords

CYCLOPAMINE; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; AGED; ARTICLE; BILIARY TRACT CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER STAGING; CANCER TISSUE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULARLY TARGETED THERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; BILE DUCTS, EXTRAHEPATIC; BILIARY TRACT NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS;

ERINACEIDAE;

EID: 84855210344     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.598     Document Type: Article

References (20)

1. Vauthey JN and Blumgart LH: Recent advances in the management of cholangiocarcinomas. Semin Liv Dis 14: 109-114, 1994.
2. Altaee MY, Johnson PJ, Farrant JM and Williams R: Etiologic and clinical characteristics of peripheral and hilar cholangiocarcinoma. Cancer 68: 2051-2055, 1991.
3. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA and Baylin SB: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422: 313-317, 2003. (Pubitemid 36378358)
4. Thayer SP, di Magliano MP, Heiser PW, et al: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856, 2003. (Pubitemid 37355945)
5. Yanai K, Nagai S, Wada J, et al: Hedgehog signaling pathway is a possible therapeutic target for gastric cancer. J Surg Oncol 95: 55-62, 2007. (Pubitemid 46122719)
6. Berman DM, Karhadkar SS, Maitra A, et al: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425: 846-851, 2003. (Pubitemid 37351469)
7. Jinawath A, Akiyama Y, Sripa B and Yuasa Y: Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol 133: 271-278, 2007.
8. Shaib YH, El-Serag HB, Nooka AK, et al: Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study. Am J Gastroenterol 102: 1016-1021, 2007. (Pubitemid 46698225)
9. Dahmane N, Lee J, Robins P, Heller P and Ruiz i Altaba A: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389: 876-881, 1997. (Pubitemid 27462984)
10. Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-331, 2004. (Pubitemid 39551660)
11. Berman DM, Karhadkar SS, Hallahan AR, et al: Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561, 2002. (Pubitemid 34971004)
12. Bhattacharya R, Kwon J, Ali B, et al: Role of hedgehog signaling in ovarian cancer. Clin Cancer Res 14: 7659-7666, 2008.
13. Jang KT, Lee KT, Lee JG, et al: Immunohistochemical expression of Sonic hedgehog in intraductal papillary mucinous tumor of the pancreas. Appl Immunohistochem Mol Morphol 15: 294-298, 2007. (Pubitemid 47329921)
14. Lee SY, Han HS, Lee KY, et al: Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep 17: 1051-1055, 2007.
15. Amankulor NM, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA and Holland EC: Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosci 29: 10299-10308, 2009.
16. Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009, 2000.
17. Incardona JP, Gaffield W, Kapur RP and Roelink H: The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125: 3553-3562, 1998. (Pubitemid 28469956)
18. Lipinski RJ, Hutson PR, Hannam PW, et al: Dose- and route.dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci 104: 189-197, 2008. (Pubitemid 351859041)
19. Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26: 1698-1705, 2005. (Pubitemid 41487985)
20. Merchant AA and Matsui W: Targeting Hedgehog . a cancer stem cell pathway. Clin Cancer Res 16: 3130-3140, 2010.