Importance of exercise immunology in health promotion

Amino Acids

Volumn 41, Issue 5, 2011, Pages 1165-1172

  Rosa Neto, J C ^a   Lira, F S ^a   De Mello, M T ^a   Santos, Ronaldo Vagner T ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute physical exercise; Chronic physical exercise; Glutamine; Immunosuppression; Inflammation; Moderate training

Indexed keywords

CYTOKINE; GLUTAMINE; IMMUNOGLOBULIN A; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID METABOLISM; CHRONIC DISEASE; DISEASE ASSOCIATION; EXERCISE; HEALTH PROMOTION; HEART FAILURE; HUMAN; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LEUKOCYTOSIS; MALNUTRITION; NONHUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; REGULATORY MECHANISM; REVIEW; RISK ASSESSMENT; RISK FACTOR; SALIVA LEVEL; THERAPY EFFECT;

ANIMALS; CHRONIC DISEASE; EXERCISE; HEALTH PROMOTION; HUMANS; IMMUNE SYSTEM;

EID: 84855209720     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-010-0786-x     Document Type: Review

References (77)

1. Agostini F, Biolo G (2010) Effect of physical activity on glutamine metabolism. Curr Opin Clin Nutr Metab Care 13:58-64
2. Akerstrom TC, Pedersen BK (2007) Strategies to enhance immune function for marathon runners: what can be done? Sports Med 37:416-419 (Pubitemid 46698554)
3. Bacurau RF, Bassit RA, Sawada L, Navarro F, Martins E Jr, Costa Rosa LF (2002) Carbohydrate supplementation during intense exercise and the immune response of cyclists. Clin Nutr 21:423-429
4. Bassit RA, Sawada LA, Bacurau RF, Navarro F, Costa Rosa LF (2000) The effect of BCAA supplementation upon the immune response of triathletes. Med Sci Sports Exerc 32:1214-1219 (Pubitemid 30482648)
5. Bassit RA, Sawada LA, Bacurau RF, Navarro F, Martins E Jr, Santos RV, Caperuto E, Costa Rosa LF (2002) Branched-chain amino acid supplementation and the immune response of long-distance athletes. Nutrition 18:376-379 (Pubitemid 34414964)
6. Batista ML Jr, Santos RV, Cunha LM, Mattos K, Oliveira EM, Seelaender MC, Costa Rosa LF (2006) Changes in the proinflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure. Cytokine 34:284-290 (Pubitemid 44224110)
7. Batista ML Jr, Santos RV, Oliveira EM, Seelaender MC, Costa Rosa LF (2007) Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats. J Appl Physiol 102:2033-2039 (Pubitemid 46701976)
8. Batista ML Jr, Santos RV, Lopes RD, Lopes AC, Costa Rosa LF, Seelaender MC (2008) Endurance training modulates lymphocyte function in rats with post-MI CHF. Med Sci Sports Exerc 40:549-556 (Pubitemid 351294673)
9. Bradfield RB, Paulos J, Grossman L (1971) Energy expenditure and heart rate of obese high school girls. Am J Clin Nutr 24:1482-1488
10. Bruunsgaard H, Hartkopp A, Mohr T, Konradsen H, Heron I, Mordhorst CH (1997) In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise. Med Sci Sports Exerc 29:1176-1181 (Pubitemid 27407139)
11. Castell LM (2002) Can glutamine modify the apparent immunodepression observed after prolonged, exhaustive exercise? Nutrition 18:371-375 (Pubitemid 34414963)
12. Castell L (2003) Glutamine supplementation in vitro and in vivo, in exercise and in immunodepression. Sports Med 33:323-345 (Pubitemid 36560707)
13. Castell LM, Newsholme EA (1998) Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 76:524-532 (Pubitemid 28549627)
14. Castell LM, Newsholme EA (2001) The relation between glutamine and the immunodepression observed in exercise. Amino Acids 20:49-61 (Pubitemid 32186469)
15. Choquette G, Ferguson RJ (1973) Blood pressure reduction in "borderline" hypertensives following physical training. Can Med Assoc J 108:699-703
16. Cornelissen VA, Fagard RH (2002) Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension 46:667-675
17. Costa Rosa LF (2004) Exercise as a time-conditioning effector in chronic disease: a complementary treatment strategy. Evid Based Complement Alternat Med 1:63-70
18. Cunha WD, Friedler G, Vaisberg M, Egami MI, Costa Rosa LF (2003) Immunosuppression in undernourished rats: the effect of glutamine supplementation. Clin Nutr 22:453-457 (Pubitemid 37259248)
19. Dachs R (2007) Exercise is an effective intervention in overweight and obese patients. Am Fam Physician 75:1333-1335
20. Decombaz J, Reinhardt P, Anantharaman K, von Glutz G, Poortmans JR (1979) Biochemical changes in a 100 km run: free amino acids, urea, and creatinine. Eur J Appl Physiol Occup Physiol 41:61-72 (Pubitemid 10158145)
21. dos Santos Cunha WD, Giampietro MV, De Souza DF, Vaisberg M, Seelaender MC, Rosa LF (2004) Exercise restores immune cell function in energy-restricted rats. Med Sci Sports Exerc 36:2059-2064 (Pubitemid 39612846)
22. dos Santos RV, Caperuto EC, de Mello MT, Batista ML Jr, Rosa LF (2009) Effect of exercise on glutamine synthesis and transport in skeletal muscle from rats. Clin Exp Pharmacol Physiol 36:770-775
23. Driver S, Taylor SR (1996) Sleep disturbances and exercise. Sports Med 21:1-6
24. Eckstein RW (1957) Effect of exercise and coronary artery narrowing on coronary collateral circulation. Circ Res 5:230-235
25. Fagard RH, Cornelissen VA (2007) Effect of exercise on blood pressure control in hypertensive patients. Eur J Cardiovasc Prev Rehabil 14:12-17
26. Garrett-Cox RG, Stefanutti G, Booth C, Klein NJ, Pierro A, Eaton S (2009) Glutamine decreases inflammation in infant rat endotoxemia. J Pediatr Surg 44:523-529
27. Gleeson M (2008) Dosing and efficacy of glutamine supplementation in human exercise and sport training. J Nutr 138:2045S-2049S
28. Guggilam A, Haque M, Kerut EK, McIlwain E, Lucchesi P, Seghal I, Francis J (2007) TNF-a blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats. Am J Physiol 293:H599-H609 (Pubitemid 47105121)
29. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 116:1081-1093 (Pubitemid 47329572)
30. Heller EM (1967) Rehabilitation after myocardial infarction: practical experience with a graded exercise program. Can Med Assoc J 97:22-27
31. Hiscock N, Pedersen BK (2002) Exercise-induced immunodepression- plasma glutamine is not the link. J Appl Physiol 93:813-822 (Pubitemid 34919649)
32. Huang YC (2001a) Malnutrition in the critically ill. Nutrition 17:263-264
33. Huang YC (2001b) Malnutrition in the critically ill. Nutrition 17:745-746
34. Jennen C, Uhlenbruck G (2004) Exercise and life-satisfactory-fitness: complementary strategies in the prevention and rehabilitation of illnesses. Evid Based Complement Alternat Med 1:157-165
35. Koyama K, Kaya M, Tsujita J, Hori S (1998) Effects of decreased plasma glutamine concentrations on peripheral lymphocyte proliferation in rats. Eur J Appl Physiol Occup Physiol 77:25-31 (Pubitemid 28089997)
36. Kretzmann NA, Fillmann H, Mauriz JL, Marroni CA, Marroni N, González-Gallego J, Tuñón MJ (2008) Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm Bowel Dis 14:1504-1513
37. Lira FS, Koyama CH, Yamashita AS, Rosa JC, Zanchi NE, Batista ML, Seelaender MC Jr (2009a) Chronic exercise decreases cytokine production in healthy rat skeletal muscle. Cell Biochem Funct 27:458-461
38. Lira FS, Rosa JC, Yamashita AS, Koyama CH, Batista ML Jr, Seelaender M (2009b) Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue. Cytokine 45:80-85
39. Lira FS, Rosa JC, Zanchi NE, Yamashita AS, Lopes RD, Lopes AC, Batista ML Jr, Seelaender M (2009c) Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise. Cell Biochem Funct 27:71-75
40. Lira FS, Rosa JC, Pimentel GD, Tarini VA, Arida RM, Faloppa F, Alves ES, do Nascimento CO, Oyama LM, Seelaender M, de Mello MT, Santos RV (2010) Inflammation and adipose tissue: effects of progressive load training in rats. Lipids Health Dis 9:109
41. Mathur N, Pedersen BK (2008) Exercise as a mean to control lowgrade systemic inflammation. Mediators Inflamm 2008:109502
42. McGavock JM, Eves ND, Mandic S, Glenn NM, Quinney HA, Haykowsky MJ (2004) The role of exercise in the treatment of cardiovascular disease associated with type 2 diabetes mellitus. Sports Med 34:27-48 (Pubitemid 38186943)
43. Moreira A, Kekkonen RA, Delgado L, Fonseca J, Korpela R, Haahtela T (2007) Nutritional modulation of exercise-induced immunodepression in athletes: asystematic review and metaanalysis. Eur J Clin Nutr 61:443-460 (Pubitemid 46605215)
44. Nagatomi R (2006) The implication of alterations in leukocyte subset counts on immune function. Exerc Immunol Rev 12:54-71
45. Negro M, Giardina S, Marzani B, Marzatico F (2008) Branched-chain amino acid supplementation does not enhance athletic performance but affects muscle recovery and the immune system. J Sports Med Phys Fitness 48:347-351
46. Newsholme EA, Calder PC (1997) The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal. Nutrition 13:728-730 (Pubitemid 27347181)
47. Newsholme EA, Crabtree B, Ardawi MS (1985a) Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q J Exp Physiol 70:473-489 (Pubitemid 16255147)
48. Newsholme EA, Crabtree B, Ardawi MS (1985b) The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci Rep 5:393-400 (Pubitemid 15067685)
49. Newsholme P, Costa Rosa LF, Newsholme EA, Curi R (1996) The importance of fuel metabolism to macrophage function. Cell Biochem Funct 14:1-10 (Pubitemid 26055410)
50. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M (2008) Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 56:2045-2052
51. Nieman DC (1997) Immune response to heavy exertion. J Appl Physiol 82:1385-1394 (Pubitemid 27203843)
52. Nieman DC (2007) Marathon training and immune function. Sports Med 37:412-415 (Pubitemid 46698553)
53. Ortega E (2003) Neuroendocrine mediators in the modulation of phagocytosis by exercise: physiological implications. Exerc Immunol Rev 9:70-93
54. Pallaro AN, Roux ME, Slobodianik NH (2001) Nutrition disorders and immunologic parameters: study of the thymus in growing rats. Nutrition 17:724-728 (Pubitemid 32816318)
55. Parry-Billings M, Newsholme EA (1991) The possible role of glutamine substrate cycles in skeletal muscle. Biochem J 279:327-328
56. Parry-Billings M, Leighton B, Dimitriadis GD, Bond J, Newsholme EA (1990) Effects of physiological and pathological levels of glucocorticoids on skeletal muscle glutamine metabolism in the rat. Biochem Pharmacol 40:1145-1148 (Pubitemid 20259723)
57. Parry-Billings M, Budgett R, Koutedakis Y, Blomstrand E, Brooks S, Williams C, Calder PC, Pilling S, Baigrie R, Newsholme EA (1992) Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system. Med Sci Sports Exerc 24:1353-1358 (Pubitemid 23006956)
58. Pedersen BK, Hoffman-Goetz L (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80:1055-1081 (Pubitemid 30452011)
59. Pedersen BK, Saltin B (2006) Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 16(Suppl 1):3-63 (Pubitemid 43433766)
60. Petersen AM, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98:1154-1162 (Pubitemid 40396484)
61. Riess KJ, Gourishankar S, Oreopoulos A, Jones LW, McGavock JM, Lewanczuk RZ, Haykowsky MJ (2006) Impaired arterial compliance and aerobic endurance in kidney transplant recipients. Transplantation 82:920-923 (Pubitemid 44564038)
62. Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson M (1999) Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20:128-135 (Pubitemid 29112673)
63. Rohde T, Ullum H, Rasmussen JP, Kristensen JH, Newsholme E, Pedersen BK (1995) Effects of glutamine on the immune system: influence of muscular exercise and HIV infection. J Appl Physiol 79:146-150
64. Rosa Neto JC, Lira FS, Oyama LM, Zanchi NE, Yamashita AS, Batista ML Jr, Oller do Nascimento CM, Seelaender M (2009) Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. Eur J Appl Physiol 106:697-704
65. Santos RV, Caperuto EC, Costa Rosa LF (2007a) Effects of acute exhaustive physical exercise upon glutamine metabolism of lymphocytes from trained rats. Life Sci 80:573-578 (Pubitemid 46038332)
66. Santos RV, Tufik S, De Mello MT (2007b) Exercise, sleep and cytokines: is there a relation? Sleep Med Rev 11:231-239 (Pubitemid 46756376)
67. Santos RV, Caperuto EC, de Mello MT, Costa Rosa LF (2009) Effect of exercise on glutamine metabolism in macrophages of trained rats. Eur J Appl Physiol 107:309-315
68. Singleton KD, Wischmeyer PE (2008) Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation. Biochem Biophys Res Commun 373:445-449
69. Soliman S, Aronson WJ, Barnard RJ (2009) analyzing serumstimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention. Evid Based Complement Alternat Med 6:1-7
70. Strohacker K, McFarlin BK (2010) Influence of obesity, physical inactivity, and weight cycling on chronic inflammation. Front Biosci (Elite Ed) 1:98-104
71. Turnbull AV, Rivier C (1995) Regulation of the HPA axis by cytokines. Brain Behav Immun 9:253-275 (Pubitemid 26039767)
72. Ullman D (2009) A review of a historical summit on integrative medicine. Evid Based Complement Alternat Med 7:1-4
73. Warburton DE, Nicol CW, Bredin SS (2006) Health benefits of physical activity: the evidence. CMAJ 174:801-809
74. Warburton DE, Taylor A, Bredin SS, Esch BT, Scott JM, Haykowsky MJ (2007) Central haemodynamics and peripheral muscle function during exercise in patients with chronic heart failure. Appl Physiol Nutr Metab 32:318-331
75. Willison KD, Williams P, Andrews GJ (2007) Enhancing chronic disease management: a review of key issues and strategies. Complement Ther Clin Pract 13:232-239
76. Woods JA, Vieira VJ, Keylock KT (2006) Exercise, inflammation, and innate immunity. Neurol Clin 24:585-599 (Pubitemid 44108543)
77. Zera T, Ufnal M, Szczepanska-Sadowska EJ (2008) Central TNFalpha elevates blood pressure and sensitizes to central pressor action of angiotensin II in the infarcted rats. Physiol Pharmacol59:117-121