TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

Gut

Volumn 61, Issue 2, 2012, Pages 248-254

  Jones, A M ^a   Beggs, A D ^a   Carvajal Carmona, L ^a   Farrington, S ^b   Tenesa, A ^b   Walker, M ^b   Howarth, K ^a   Ballereau, S ^b   Hodgson, S V ^c   Zauber, A ^d   Bertagnolli, M ^e   Midgley, R ^f   Campbell, H ^b   Kerr, D ^f   Dunlop, M G ^b   Tomlinson, Ian P M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; ARTICLE; BINDING SITE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL ADENOMA; COLORECTAL CANCER; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RNA FOLDING; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE;

ADENOMA; AGED; CARCINOMA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; HCT116 CELLS; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RNA; TELOMERASE; TELOMERE;

EID: 84855194845     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2011.239772     Document Type: Article

References (41)

1. O'Sullivan J, Risques RA, Mandelson MT, et al. Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev 2006;15:573-7.
2. Atzmon G, Cho M, Cawthon RM, et al. Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A 2010;107(Suppl 1):1710-17.
3. Walne AJ, Vulliamy T, Beswick R, et al. TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood 2008;112:3594-600.
4. Cronkhite JT, Xing C, Raghu G, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med 2008;178:729-37.
5. Du HY, Pumbo E, Ivanovich J, et al. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood 2009;113:309-16.
6. Vulliamy T, Beswick R, Kirwan M, et al. Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci U S A 2008;105:8073-8. (Pubitemid 351904710)
7. Blasco MA. Telomere length, stem cells and aging. Nat Chem Biol 2007;3:640-9. (Pubitemid 47417712)
8. Flores I, Canela A, Vera E, et al. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev 2008;22:654-67. (Pubitemid 351342437)
9. Soder AI, Hoare SF, Muir S, et al. Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 1997;14:1013-21.
10. Bischoff C, Graakjaer J, Petersen HC, et al. The heritability of telomere length among the elderly and oldest-old. Twin Res Hum Genet 2005;8:433-9.
11. Jeanclos E, Schork NJ, Kyvik KO, et al. Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 2000;36:195-200. (Pubitemid 30626988)
12. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994;55:876-82. (Pubitemid 24334278)
13. Codd V, Mangino M, van der Harst P, et al. Common variants near TERC are associated with mean telomere length. Nat Genet 2010;42:197-9.
14. Levy D, Neuhausen SL, Hunt SC, et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A 2010;107:9293-8.
15. Perona R, Machado-Pinilla R, Manguan C, et al. Telomerase deficiency and cancer susceptibility syndromes. Clin Transl Oncol 2009;11:711-14.
16. Calado RT, Regal JA, Hills M, et al. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A 2009;106:1187-92.
17. Alter BP, Giri N, Savage SA, et al. Cancer in dyskeratosis congenita. Blood 2009;113:6549-57.
18. Scheinberg P, Cooper JN, Sloand EM, et al. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia. JAMA 2010;304:1358-64.
19. Barwell J, Pangon L, Georgiou A, et al. Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? Br J Cancer 2007;97:1696-700. (Pubitemid 350249357)
20. Broberg K, Bjork J, Paulsson K, et al. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis 2005;26:1263-71. (Pubitemid 41417904)
21. Prescott J, McGrath M, Lee IM, et al. Telomere length and genetic analyses in population-based studies of endometrial cancer risk. Cancer 2010;116:4275-82.
22. Rosenberg R, Gertler R, Stricker D, et al. Telomere length and hTERT expression in patients with colorectal carcinoma. Recent Results Cancer Res 2003;162:177-81.
23. Yoon SL, Jung SI, Do EJ, et al. Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression. BMC Cancer 2010;10:393.
24. Zee RY, Castonguay AJ, Barton NS, et al. Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested caseecontrol approach. Cancer Epidemiol Biomarkers Prev 2009;18:2280-2.
25. Lee IM, Lin J, Castonguay AJ, et al. Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested caseecontrol study. Clin Chem Lab Med 2010;48:259-62.
26. Pooley KA, Sandhu MS, Tyrer J, et al. Telomere length in prospective and retrospective cancer caseecontrol studies. Cancer Res 2010;70:3170-6.
27. Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA 2010;304:69-75.
28. Risques RA, Lai LA, Brentnall TA, et al. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology 2008;135:410-18.
29. Nakamura K, Furugori E, Esaki Y, et al. Correlation of telomere lengths in normal and cancers tissue in the large bowel. Cancer Lett 2000;158:179-84.
30. Rampazzo E, Bertorelle R, Serra L, et al. Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer 2010;102:1300-5.
31. Houlston RS, Cheadle J, Dobbins SE, et al. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat Genet 2010;42:973-7.
32. Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009;37:e21.
33. Mirabello L, Yu K, Kraft P, et al. The association of telomere length and genetic variation in telomere biology genes. Hum Mutat 2010;31:1050-8.
34. Pooley KA, Tyrer J, Shah M, et al. No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev 2010;19:1862-5.
35. Baird DM. Variation at the TERT locus and predisposition for cancer. Expert Rev Mol Med 2010;12:e16.
36. Bertagnolli MM, Eagle CJ, Zauber AG, et al. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 2006;355:873-84. (Pubitemid 44315980)
37. Power C. A review of child health in the 1958 birth cohort: National Child Development Study. Paediatr Perinat Epidemiol 1992;6:81-110.
38. Hao ZM, Luo JY, Cheng J, et al. Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway. Cancer Biol Ther 2005;4:1098-103. (Pubitemid 41598564)
39. Parkinson EK, Fitchett C, Cereser B. Dissecting the non-canonical functions of telomerase. Cytogenet Genome Res 2008;122:273-80.
40. Rahman R, Latonen L, Wiman KG. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 2005;24:1320-7. (Pubitemid 40343112)
41. Artandi SE, Alson S, Tietze MK, et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci U S A 2002;99:8191-6. (Pubitemid 34651028)