Novel bioactive metabolites of dipyrone (metamizol)

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 101-107

  Rogosch, Tobias ^a   Sinning, Christian ^b   Podlewski, Agnes ^a   Watzer, Bernhard ^a   Schlosburg, Joel ^c   Lichtman, Aron H ^c   Cascio, Maria G ^d,f   Bisogno, Tiziana ^d   Di Marzo, Vincenzo ^d   Nüsing, Rolf ^e   Imming, Peter ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d CNR   (Italy)

^e Institut fur Klinische Pharmakologie   (Germany)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Analgesia; Arachidonic acid amides; Cannabinoid receptors; Cyclooxygenase; Dipyrone

Indexed keywords

4 AMINOPHENAZONE; AMIDE; ARACHIDONOYL AMIDE DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIPYRONE; NORAMIDOPYRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME ISOLATION; MOUSE; NONHUMAN;

ADMINISTRATION, ORAL; AMINOPYRIDINES; AMPYRONE; ANIMALS; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DIPYRONE; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CANNABIS; MUS;

EID: 84855191211     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.028     Document Type: Article

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