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Volumn 422, Issue 2, 2012, Pages 357-365

Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP™ system

Author keywords

Cervical cancer; DNA methylation; E2 binding site; E6 E7 deregulation; Human papillomavirus 16

Indexed keywords

E2BS1 PROTEIN; E2BS2 PROTEIN; E2BS3 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84855189776     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.11.006     Document Type: Article
Times cited : (32)

References (67)
  • 1
    • 0023178843 scopus 로고
    • Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA
    • Androphy E.J., Lowy D.R., Schiller J.T. Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Nature 1987, 325:70-73.
    • (1987) Nature , vol.325 , pp. 70-73
    • Androphy, E.J.1    Lowy, D.R.2    Schiller, J.T.3
  • 2
    • 0038365277 scopus 로고    scopus 로고
    • CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression
    • Badal V., Chuang L.S., Tan E.H., Badal S., Villa L.L., Wheeler C.M., Li B.F., Bernard H.U. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J. Virol. 2003, 77:6227-6234.
    • (2003) J. Virol. , vol.77 , pp. 6227-6234
    • Badal, V.1    Chuang, L.S.2    Tan, E.H.3    Badal, S.4    Villa, L.L.5    Wheeler, C.M.6    Li, B.F.7    Bernard, H.U.8
  • 3
    • 0023144684 scopus 로고
    • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker C.C., Phelps W.C., Lindgren V., Braun M.J., Gonda M.A., Howley P.M. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol. 1987, 61:962-971.
    • (1987) J. Virol. , vol.61 , pp. 962-971
    • Baker, C.C.1    Phelps, W.C.2    Lindgren, V.3    Braun, M.J.4    Gonda, M.A.5    Howley, P.M.6
  • 4
    • 84855205177 scopus 로고    scopus 로고
    • Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression
    • Bellanger S., Tan C.L., Xue Y.Z., Teissier S., Thierry F. Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res 2011, 1:373-389.
    • (2011) Am J Cancer Res , vol.1 , pp. 373-389
    • Bellanger, S.1    Tan, C.L.2    Xue, Y.Z.3    Teissier, S.4    Thierry, F.5
  • 5
    • 33749537658 scopus 로고    scopus 로고
    • CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
    • Bhattacharjee B., Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006, 354:280-285.
    • (2006) Virology , vol.354 , pp. 280-285
    • Bhattacharjee, B.1    Sengupta, S.2
  • 6
    • 30444455306 scopus 로고    scopus 로고
    • HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women
    • Bhattacharjee B., Sengupta S. HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women. Gynecol. Oncol. 2006, 100:372-378.
    • (2006) Gynecol. Oncol. , vol.100 , pp. 372-378
    • Bhattacharjee, B.1    Sengupta, S.2
  • 7
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16:6-21.
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 8
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer S.N., Wazer D.E., Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 1996, 56:4620-4624.
    • (1996) Cancer Res. , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 9
    • 0026583975 scopus 로고
    • Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein
    • Boyes J., Bird A. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J. 1992, 11:327-333.
    • (1992) EMBO J. , vol.11 , pp. 327-333
    • Boyes, J.1    Bird, A.2
  • 12
    • 0028054334 scopus 로고
    • Papillomavirus DNA replication
    • Chow L.T., Broker T.R. Papillomavirus DNA replication. Intervirology 1994, 37:150-158.
    • (1994) Intervirology , vol.37 , pp. 150-158
    • Chow, L.T.1    Broker, T.R.2
  • 13
    • 0025964888 scopus 로고
    • Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm
    • Cullen A.P., Reid R., Campion M., Lorincz A.T. Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J. Virol. 1991, 65:606-612.
    • (1991) J. Virol. , vol.65 , pp. 606-612
    • Cullen, A.P.1    Reid, R.2    Campion, M.3    Lorincz, A.T.4
  • 16
    • 0028039853 scopus 로고
    • Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements
    • Dong G., Broker T.R., Chow L.T. Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements. J. Virol. 1994, 68:1115-1127.
    • (1994) J. Virol. , vol.68 , pp. 1115-1127
    • Dong, G.1    Broker, T.R.2    Chow, L.T.3
  • 17
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick J.J., McBride A.A., Howley P.M. Suppression of cellular proliferation by the papillomavirus E2 protein. J. Virol. 1995, 69:7791-7799.
    • (1995) J. Virol. , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 18
    • 28544446736 scopus 로고    scopus 로고
    • Applications of Luminex xMAP technology for rapid, high-throughput multiplexed nucleic acid detection
    • Dunbar S.A. Applications of Luminex xMAP technology for rapid, high-throughput multiplexed nucleic acid detection. Clin. Chim. Acta 2006, 363:71-82.
    • (2006) Clin. Chim. Acta , vol.363 , pp. 71-82
    • Dunbar, S.A.1
  • 19
    • 67650117740 scopus 로고    scopus 로고
    • Multiplex and quantifiable detection of nucleic acid from pathogenic fungi using padlock probes, generic real time PCR and specific suspension array readout
    • Eriksson R., Jobs M., Ekstrand C., Ullberg M., Herrmann B., Landegren U., Nilsson M., Blomberg J. Multiplex and quantifiable detection of nucleic acid from pathogenic fungi using padlock probes, generic real time PCR and specific suspension array readout. J. Microbiol. Methods 2009, 78:195-202.
    • (2009) J. Microbiol. Methods , vol.78 , pp. 195-202
    • Eriksson, R.1    Jobs, M.2    Ekstrand, C.3    Ullberg, M.4    Herrmann, B.5    Landegren, U.6    Nilsson, M.7    Blomberg, J.8
  • 21
    • 0028598275 scopus 로고
    • Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein
    • Frattini M.G., Laimins L.A. Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:12398-12402.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 12398-12402
    • Frattini, M.G.1    Laimins, L.A.2
  • 22
    • 0028932663 scopus 로고
    • CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genes
    • Gaston K., Fried M. CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genes. Nucleic Acids Res. 1995, 23:901-909.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 901-909
    • Gaston, K.1    Fried, M.2
  • 23
    • 0024990398 scopus 로고
    • The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element
    • Gloss B., Bernard H.U. The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element. J. Virol. 1990, 64:5577-5584.
    • (1990) J. Virol. , vol.64 , pp. 5577-5584
    • Gloss, B.1    Bernard, H.U.2
  • 25
    • 0036086459 scopus 로고    scopus 로고
    • The papillomavirus E2 proteins: structure, function, and biology
    • Hegde R.S. The papillomavirus E2 proteins: structure, function, and biology. Annu. Rev. Biophys. Biomol. Struct. 2002, 31:343-360.
    • (2002) Annu. Rev. Biophys. Biomol. Struct. , vol.31 , pp. 343-360
    • Hegde, R.S.1
  • 26
    • 0024083068 scopus 로고
    • Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated
    • Holler M., Westin G., Jiricny J., Schaffner W. Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes Dev. 1988, 2:1127-1135.
    • (1988) Genes Dev. , vol.2 , pp. 1127-1135
    • Holler, M.1    Westin, G.2    Jiricny, J.3    Schaffner, W.4
  • 27
    • 0028107023 scopus 로고
    • Cellular control of human papillomavirus oncogene transcription
    • Hoppe-Seyler F., Butz K. Cellular control of human papillomavirus oncogene transcription. Mol. Carcinog. 1994, 10:134-141.
    • (1994) Mol. Carcinog. , vol.10 , pp. 134-141
    • Hoppe-Seyler, F.1    Butz, K.2
  • 28
  • 30
    • 0028900490 scopus 로고
    • Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis
    • Jeon S., Lambert P.F. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:1654-1658.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 1654-1658
    • Jeon, S.1    Lambert, P.F.2
  • 32
    • 42649098924 scopus 로고    scopus 로고
    • Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines
    • Kalantari M., Lee D., Calleja-Macias I.E., Lambert P.F., Bernard H.U. Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines. Virology 2008, 374:292-303.
    • (2008) Virology , vol.374 , pp. 292-303
    • Kalantari, M.1    Lee, D.2    Calleja-Macias, I.E.3    Lambert, P.F.4    Bernard, H.U.5
  • 33
    • 0242661842 scopus 로고    scopus 로고
    • Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection
    • Kim K., Garner-Hamrick P.A., Fisher C., Lee D., Lambert P.F. Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J. Virol. 2003, 77:12450-12459.
    • (2003) J. Virol. , vol.77 , pp. 12450-12459
    • Kim, K.1    Garner-Hamrick, P.A.2    Fisher, C.3    Lee, D.4    Lambert, P.F.5
  • 34
    • 0027448626 scopus 로고
    • Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type 11 origin
    • Lu J.Z., Sun Y.N., Rose R.C., Bonnez W., McCance D.J. Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type 11 origin. J. Virol. 1993, 67:7131-7139.
    • (1993) J. Virol. , vol.67 , pp. 7131-7139
    • Lu, J.Z.1    Sun, Y.N.2    Rose, R.C.3    Bonnez, W.4    McCance, D.J.5
  • 35
    • 0031727896 scopus 로고    scopus 로고
    • Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia
    • Maitland N.J., Conway S., Wilkinson N.S., Ramsdale J., Morris J.R., Sanders C.M., Burns J.E., Stern P.L., Wells M. Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia. J. Pathol. 1998, 186:275-280.
    • (1998) J. Pathol. , vol.186 , pp. 275-280
    • Maitland, N.J.1    Conway, S.2    Wilkinson, N.S.3    Ramsdale, J.4    Morris, J.R.5    Sanders, C.M.6    Burns, J.E.7    Stern, P.L.8    Wells, M.9
  • 36
    • 0028312123 scopus 로고
    • Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene
    • Myohanen S., Wahlfors J., Janne J. Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene. DNA Seq. 1994, 5:1-8.
    • (1994) DNA Seq. , vol.5 , pp. 1-8
    • Myohanen, S.1    Wahlfors, J.2    Janne, J.3
  • 37
    • 56249113835 scopus 로고    scopus 로고
    • A novel method of HPV genotyping using Hybrid Capture sample preparation method combined with GP5+/6+ PCR and multiplex detection on Luminex XMAP
    • Nazarenko I., Kobayashi L., Giles J., Fishman C., Chen G., Lorincz A. A novel method of HPV genotyping using Hybrid Capture sample preparation method combined with GP5+/6+ PCR and multiplex detection on Luminex XMAP. J. Virol. Methods 2008, 154:76-81.
    • (2008) J. Virol. Methods , vol.154 , pp. 76-81
    • Nazarenko, I.1    Kobayashi, L.2    Giles, J.3    Fishman, C.4    Chen, G.5    Lorincz, A.6
  • 38
    • 0029819751 scopus 로고    scopus 로고
    • YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity
    • O'Connor M.J., Tan S.H., Tan C.H., Bernard H.U. YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity. J. Virol. 1996, 70:6529-6539.
    • (1996) J. Virol. , vol.70 , pp. 6529-6539
    • O'Connor, M.J.1    Tan, S.H.2    Tan, C.H.3    Bernard, H.U.4
  • 42
    • 79952029334 scopus 로고    scopus 로고
    • A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia
    • Piyathilake C.J., Macaluso M., Alvarez R.D., Chen M., Badiga S., Edberg J.C., Partridge E.E., Johanning G.L. A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer 2010, 117:957-963.
    • (2010) Cancer , vol.117 , pp. 957-963
    • Piyathilake, C.J.1    Macaluso, M.2    Alvarez, R.D.3    Chen, M.4    Badiga, S.5    Edberg, J.C.6    Partridge, E.E.7    Johanning, G.L.8
  • 44
    • 0028589386 scopus 로고
    • Kinetic and equilibrium binding studies of the human papillomavirus type-16 transcription regulatory protein E2 interacting with core enhancer elements
    • Sanders C.M., Maitland N.J. Kinetic and equilibrium binding studies of the human papillomavirus type-16 transcription regulatory protein E2 interacting with core enhancer elements. Nucleic Acids Res. 1994, 22:4890-4897.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4890-4897
    • Sanders, C.M.1    Maitland, N.J.2
  • 45
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M., Werness B.A., Huibregtse J.M., Levine A.J., Howley P.M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990, 63:1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 47
    • 33746230991 scopus 로고    scopus 로고
    • Determination of viral load thresholds in cervical scrapings to rule out CIN 3 in HPV 16, 18, 31 and 33-positive women with normal cytology
    • Snijders P.J., Hogewoning C.J., Hesselink A.T., Berkhof J., Voorhorst F.J., Bleeker M.C., Meijer C.J. Determination of viral load thresholds in cervical scrapings to rule out CIN 3 in HPV 16, 18, 31 and 33-positive women with normal cytology. Int. J. Cancer 2006, 119:1102-1107.
    • (2006) Int. J. Cancer , vol.119 , pp. 1102-1107
    • Snijders, P.J.1    Hogewoning, C.J.2    Hesselink, A.T.3    Berkhof, J.4    Voorhorst, F.J.5    Bleeker, M.C.6    Meijer, C.J.7
  • 51
    • 0031060198 scopus 로고    scopus 로고
    • Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein
    • Steger G., Corbach S. Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein. J. Virol. 1997, 71:50-58.
    • (1997) J. Virol. , vol.71 , pp. 50-58
    • Steger, G.1    Corbach, S.2
  • 52
    • 79952816838 scopus 로고    scopus 로고
    • Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer
    • Sun C., Reimers L.L., Burk R.D. Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer. Gynecol. Oncol. 2011, 121:59-63.
    • (2011) Gynecol. Oncol. , vol.121 , pp. 59-63
    • Sun, C.1    Reimers, L.L.2    Burk, R.D.3
  • 53
    • 0029865524 scopus 로고    scopus 로고
    • Mapping of HPV-11 E1 binding site and determination of other important cis elements for replication of the origin
    • Sun Y.N., Lu J.Z., McCance D.J. Mapping of HPV-11 E1 binding site and determination of other important cis elements for replication of the origin. Virology 1996, 216:219-222.
    • (1996) Virology , vol.216 , pp. 219-222
    • Sun, Y.N.1    Lu, J.Z.2    McCance, D.J.3
  • 54
    • 0037455541 scopus 로고    scopus 로고
    • A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16
    • Tan S.H., Baker C.C., Stunkel W., Bernard H.U. A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16. Virology 2003, 305:486-501.
    • (2003) Virology , vol.305 , pp. 486-501
    • Tan, S.H.1    Baker, C.C.2    Stunkel, W.3    Bernard, H.U.4
  • 55
    • 0028086064 scopus 로고
    • The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID
    • Tan S.H., Leong L.E., Walker P.A., Bernard H.U. The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID. J. Virol. 1994, 68:6411-6420.
    • (1994) J. Virol. , vol.68 , pp. 6411-6420
    • Tan, S.H.1    Leong, L.E.2    Walker, P.A.3    Bernard, H.U.4
  • 56
    • 0025266610 scopus 로고
    • Alternative chromatin structure at CpG islands
    • Tazi J., Bird A. Alternative chromatin structure at CpG islands. Cell 1990, 60:909-920.
    • (1990) Cell , vol.60 , pp. 909-920
    • Tazi, J.1    Bird, A.2
  • 57
    • 0029815037 scopus 로고    scopus 로고
    • CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences
    • Thain A., Jenkins O., Clarke A.R., Gaston K. CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences. J. Virol. 1996, 70:7233-7235.
    • (1996) J. Virol. , vol.70 , pp. 7233-7235
    • Thain, A.1    Jenkins, O.2    Clarke, A.R.3    Gaston, K.4
  • 60
    • 6344277190 scopus 로고    scopus 로고
    • LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA
    • Vester B., Wengel J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochemistry 2004, 43:13233-13241.
    • (2004) Biochemistry , vol.43 , pp. 13233-13241
    • Vester, B.1    Wengel, J.2
  • 61
    • 80052531865 scopus 로고    scopus 로고
    • Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation
    • Vinokurova S., von Knebel Doeberitz M. Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PLoS One 2011, 6:e24451.
    • (2011) PLoS One , vol.6
    • Vinokurova, S.1    von Knebel Doeberitz, M.2
  • 63
    • 0034331178 scopus 로고    scopus 로고
    • Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways
    • Wells S.I., Francis D.A., Karpova A.Y., Dowhanick J.J., Benson J.D., Howley P.M. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J. 2000, 19:5762-5771.
    • (2000) EMBO J. , vol.19 , pp. 5762-5771
    • Wells, S.I.1    Francis, D.A.2    Karpova, A.Y.3    Dowhanick, J.J.4    Benson, J.D.5    Howley, P.M.6
  • 64
    • 31944448352 scopus 로고    scopus 로고
    • Associations of high-risk HPV types and viral load with cervical cancer in China
    • Wu Y., Chen Y., Li L., Yu G., Zhang Y., He Y. Associations of high-risk HPV types and viral load with cervical cancer in China. J. Clin. Virol. 2006, 35:264-269.
    • (2006) J. Clin. Virol. , vol.35 , pp. 264-269
    • Wu, Y.1    Chen, Y.2    Li, L.3    Yu, G.4    Zhang, Y.5    He, Y.6
  • 65
    • 77954365636 scopus 로고    scopus 로고
    • HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma
    • Xue Y., Bellanger S., Zhang W., Lim D., Low J., Lunny D., Thierry F. HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma. Cancer Res. 2010, 70:5316-5325.
    • (2010) Cancer Res. , vol.70 , pp. 5316-5325
    • Xue, Y.1    Bellanger, S.2    Zhang, W.3    Lim, D.4    Low, J.5    Lunny, D.6    Thierry, F.7
  • 66
    • 0021821058 scopus 로고
    • Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines
    • Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M. Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am. J. Pathol. 1985, 119:361-366.
    • (1985) Am. J. Pathol. , vol.119 , pp. 361-366
    • Yee, C.1    Krishnan-Hewlett, I.2    Baker, C.C.3    Schlegel, R.4    Howley, P.M.5
  • 67
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2002, 2:342-350.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1


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