YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity

Journal of Virology

Volumn 70, Issue 10, 1996, Pages 6529-6539

  O'Connor, Mark J ^a   Tan, Shyh Han ^a   Tan, Chiew Hoon ^a   Bernard, Hans Ulrich ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; VIRUS PROTEIN;

ARTICLE; BINDING SITE; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; VIRUS EXPRESSION; VIRUS TRANSCRIPTION; WART VIRUS;

EID: 0029819751     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.6529-6539.1996     Document Type: Article

References (80)

1. Apt, D., T. Chong, Y. Liu, and H. U. Bernard. 1993. Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16. J. Virol. 67:4455-4463.
2. Apt, D., Y. Liu, and H. U. Bernard. 1994. Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner. Nucleic Acids Res. 22:3825-3833.
3. Arany, Z., W. R. Sellers, D. M. Livingston, and R. Eckner. 1994. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77:799-800. (Letter.)
4. Bannister, A. J., and T. K. Kouzarides. 1995. CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J. 14:4758-4762.
5. Bannister, A. J., T. Oehler, D. Wilhelm, P. Angel, and T. Kouzarides. 1995 Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11:2509-2514.
6. Bauknecht, T., P. Angel, H. D. Royer, and H. Zur Hausen. 1992 Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J. 11:4607-4617.
7. Bauknecht, T., F. Jundt, I. Herr, T. Oehler, H. Delius, Y. Shi, P. Angel, and H. Zur Hausen. 1995. A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J. Virol. 69:1-12.
8. Bernard, H. U., and D. Apt. 1994. Transcriptional control and cell type specificity of HPV gene expression. Arch. Dermatol. 130:210-215.
9. Böhm, S., S. P. Wilczynski, H. Pfister, and T. Iftner. 1993. The predominant mRNA class in HPV-16 infected genital neoplasias does not encode the E6 or E7 protein. Int. J. Cancer 55:791-798.
10. Chan, W. K., T. Chong, H. U. Bernard, and G. Klock. 1990. Transcription of the transforming genes of the oncogenic human papillomavirus-16 is stimulated by tumor promotors through API binding sites. Nucleic Acids Res. 18:763-769.
11. Chan, W. K., G. Klock, and H. U. Bernard. 1989. Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia. J. Virol. 63:3261-3269.
12. Chen, S., L. Mills, P. Perry, S. Riddle, R. Wobig, R. Lown, and R. L. Millette. 1992. Transactivation of the major capsid protein gene of herpes simplex virus type 1 requires a cellular transcription factor. J. Virol. 66:4304-4314.
13. Chesters, P. M., K. H. Vousden, C. Edmonds, and D. J. McCance. 1990. Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells. J. Gen. Virol. 71:449-53.
14. Chevallier-Greco, A., E. Manet, P. Chavrier, C. Mosnier, J. Daillie, and A. Sergeant. 1986. Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J. 5:3243-3249.
15. Chiang, C. M., and R. G. Roeder. 1995. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. Science 267: 531-536.
16. Choo, K.-B., C.-C. Pan, M.-S. Liu, H.-T. Ng, C.-P. Chen, C.-P. Lee, C.-L. Chao, C.-L. Meng, M.-Y. Yeh, and S.-H. Han. 1987. Presence of episomal and integrated human papillomavirus DNA sequences in cervical carcinoma. J. Med. Virol. 21:101-107.
17. Chrivia, J. C., R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (London) 365:855-859.
18. Cripe, T. P., A. Alderborn, R. D. Andersen, S. Parkkinen, P. Bergman, T. H. Haugen, U. Pettersson, and L. P. Turek. 1990. Transcriptional activation of the human papillomavirus-16 P97 promoter by an 88-nucleotide enhancer containing distinct cell-dependent and AP1-responsive modules. New Biol. 2:450-463.
19. Cripe, T. P., T. H. Haugen, J. P. Turk, F. Tabatabai, P. G. Schmid, M. Dürst, L. Gissman, A. Roman, and L. P. Turek. 1987. Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 transactivator and repressor gene products: implications for cervical carcinogenesis. EMBO J. 6:3745-3753.
20. Cullen, A. P., R. Reid, M. Campion, and A. T. Lörincz. 1991. Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J. Virol. 65:606-612.
21. Dong, X. P., F. Stubenrauch, E. Beyer-Finkler, and H. Pfister. 1994. Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers. Int. J. Cancer 58:803-808.
22. Dostatni, N., P. F. Lambert, R. Sousa, J. Ham, P. M. Howley, and M. Yaniv. 1991. The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex. Genes Dev. 5:1657-1671.
23. Flanagan, J. R., K. G. Becker, D. L. Ennist, S. L. Gleason, P. H. Driggers, B.-Z. Levi, E. Appella, and K. Ozato. 1992. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol. Cell. Biol. 12:38-44.
24. Fuchs, P. G., F. Girardi, and H. Pfister. 1989. Human papillomavirus-16 DNA in cervical cancer and in lymph nodes of cervical cancer patients: a diagnostic marker for early metastasis. Int. J. Cancer 43:41-44.
25. Galloway, D. A., and J. K. McDougall. 1989. Human papillomaviruses and carcinomas. Adv. Virus Res. 37:125-171.
26. Gius, D., and L. Laimins. 1989. Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 transactivators and a phorbol ester. J. Virol. 63:555-563.
27. Gloss, B., and H. U. Bernard. 1990. The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element. J. Virol. 64:5577-5584.
28. Gloss, B., H. U. Bernard, K. Seedorf, and G. Klock. 1987. The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones. EMBO J. 6:3735-3743.
29. Gloss, B., T. Chong, and H. U. Bernard. 1989. Numerous nuclear proteins bind the long control region of human papillomavirus type 16: a subset of 6 of 23 DNase I-protected segments coincides with the location of the cell-type-specific enhancer. J. Virol. 63:1142-1152.
30. Gloss, B., M. Yeo-Gloss, M. Meisterenst, L. Rogge, E. L. Winnacker, and H. U. Bernard. 1989. Clusters of nuclear factor I binding sites identify enhancers of several papillomaviruses but alone are not sufficient for enhancer function. Nucleic Acids Res. 17:3519-3533.
31. Gorman, C., L. Mofat, and B. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
32. Gualberto, A., D. LePage, G. Pons, S. L. Mader, K. Park, M. L. Atchison, and K. Walsh. 1992. Functional antagonism between YY1 and the serum response factor. Mol. Cell. Biol. 12:4209-4214.
33. Hahn, S. 1992. The Yin and Yang of mammalian transcription. Curr. Biol. 2:152-154.
34. Hariharan, N., D. E. Kelley, and R. P. Perry. 1991. δ, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. Proc. Natl. Acad. Sci. USA 88: 9799-9803.
35. Higgins, G. D., D. M. Uzelin, G. E. Phillips, and C. J. Burrel. 1991. Presence and distribution of human papillomavirus sense and anti-sense RNA transcripts in genital cancers. J. Gen. Virol. 72:885-895.
36. Higgins, G. D., D. M. Uzelin, G. E. Phillips, P. McEvoy, R. Marin, and C. J. Burrel. 1992. Transcription patterns of human papillomavirus type 16 in genital intra-epithelial neoplasia: evidence for promoter usage within the E7 open reading frame during epithelial differentiation. J. Gen. Virol. 73: 2047-2057.
37. Hyde-DeRuyscher, R. P., E. Jennings, and T. Shenk. 1996. DNA binding sites for the transcriptional activator/repressor YY1. Nucleic Acids Res. 23:4457-4465.
38. Ishiji, T., M. Lace, S. Parkkinen, R. D. Anderson, T. H. Haugen, T. P. Cripe, J.-H. Xiao, I. Davidson, P. Chambon, and L. P. Turek. 1992. Transcriptional enhancer factor (TEF)-1 and its cell-specific co-activator activate human papillomavirus-16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells. EMBO J. 11:2271-2281.
39. Lee, J. S., K. M. Galvin, R. H. See, R. Eckner, D. Livingston, E. Moran, and Y. Shi. 1995. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 9275:1188-1198.
40. Lee, J. S., R. H. See, K. M. Galvin, J. Wang, and Y. Shi. 1995. Functional interactions between YY1 and adenovirus E1A. Nucleic Acids Res. 23:925-931.
41. Lee, T. C., Y. Shi, and R. J. Schwartz. 1992. Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts. Proc. Natl. Acad. Sci. USA 89:9814-9818.
42. Lewis, B. A., G. Tullis, E. Seto, N. Horikoshi, R. Weinmann, and T. Shenk. 1995. Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J. Virol. 69:1628-1636.
43. Liu, R., J. Baillie, J. G. Sissons, and J. H. Sinclair. 1994. The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells. Nucleic Acids Res. 22:2453-2459.
44. Lu, S. Y., M. Rodriguez, and W. S. Liao. 1994. YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-κB during acute-phase response. Mol. Cell. Biol. 14:6253-6263.
45. Lundblad, J. R., R. P. Kwok, M. E. Laurance, M. L. Harter, and R. H. Goodman. 1995. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature (London) 374: 85-88.
46. Margolis, D. M., M. Somasundaran, and M. R. Green. 1994. Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production. J. Virol. 68:905-910.
47. May, M., X. P. Dong, E. Beyer-Finkler, F. Stubenrauch, P. G. Fuchs, and H. Pfister. 1994. The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1. EMBO J. 13:1460-1466.
48. McBride, A. A., H. Romanczuk, and P. M. Howley. 1991. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266:18411-18414.
49. Meier, V. S., and B. Groner. 1994. The nuclear factor YY1 participates in repression of the β-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction. Mol. Cell. Biol. 14:128-137.
50. Montalvo, E., S. Yang, T. Shenk, and A. Levine. 1991. Negative regulation of the BZLF1 promoter of Epstein-Barr virus. J. Virol. 65:3647-3655.
51. Montalvo, E. A., M. Cottam, S. Hill, and Y. J. Wang. 1995. YY1 binds to and regulates cis-acting negative elements in the Epstein-Barr virus BZLF1 promoter. J. Virol. 69:4158-4165.
52. Münger, K., W. C. Phelps, V. Bubb, P. M. Howley, and R. Schlegel. 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417-4421.
53. Natesan, S., and M. Gilman. 1995. YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol. Cell. Biol. 15:5975-5982.
54. Natesan, S., and M. Z. Gilman. 1993. DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev. 7:2497-2509.
55. O'Connor, M., and H. U. Bernard. 1995. Oct-1 activates the epithelial-specific enhancer of human papillomavirus type 16 via a synergistic interaction with NFI at a conserved composite regulatory element. Virology 207: 77-88.
56. O'Connor, M., S. Y. Chan, and H. U. Bernard. 1995. Transcription factor binding sites in the long control region of genital HPVs, p. 21-40. In G. Myers, H. U. Bernard, H. Delius, J. Icenogle, C. Baker, A. Halpern, and C. Wheeler (ed.), Human papillomaviruses. Los Alamos National Laboratory, Los Alamos N.Mex.
57. O'Connor, M. J. 1996. Unpublished observations.
58. Park, K., and M. L. Atchison. 1991. Isolation of a candidate repressor/ activator, NF-E1 (YY1, 8), that binds to the immunoglobulin k 3′ enhancer and the immunoglobulin heavy-chain enhancer. Proc. Natl. Acad. Sci. USA 88:9804-9808.
59. Riggs, K. J., K. T. Merrell, G. Wilson, and K. Calame. 1991. Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal α-actin promoter, and the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 11:1765-1769.
60. Rivera, V., M. Sheng, and M. Greenberg. 1990. The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation. Genes Dev. 4:255-268.
61. Rösl, F., T. Achtstätter, T. Bauknecht, K.-J. Hutter, G. Futterman, and H. Zur Hausen. 1991. Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions. EMBO J. 10:1337-1345.
62. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
63. Schüle, R., M. Muller, H. Otsuka-Murakami, and R. Renkawitz. 1988. Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature (London) 332:87-90.
64. Schwarz, E., U. K. Freese, L. Gissman, W. Mayer, B. Roggenbuck, A. Stremlau, and H. Zur Hausen. 1985. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (London) 314:111-114.
65. Seto, E., B. Lewis, and T. Shenk. 1993. Interaction between transcription factors Sp1 and YY1. Nature (London) 365:462-464.
66. Seto, E., Y. Shi, and T. Shenk. 1991. YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature (London) 354:241-245.
67. Shi, Y., E. Seto, L. S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388.
68. Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22:5151-5155.
69. Shrivastava, A., S. Saleque, G. V. Kalpana, S. Artandi, S. P. Goff, and K. Calame. 1993. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262:1889-1892.
70. Sibbet, G. J., and M. S. Campo. 1990. Multiple interactions between cellular factors and the non-coding region of human papillomavirus type 16. J. Gen. Virol. 71:2699-2707.
71. Tan, S. H., L. E. Leong, P. A. Walker, and H. U. Bernard. 1994. The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of SpI and TFIID. J. Virol. 68:6411-6420.
72. Trouche, D., and T. Kouzarides. E2F1 and E1A 12S have a homologous activation domain regulated by RB and CBP. Proc. Natl. Acad. Sci. USA, in press.
73. Usheva, A., and T. Shenk. 1994. TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA. Cell 76:1115-1121.
74. Vincent, C. K., A. Gualberto, C. V. Patel, and K. Walsh. 1993. Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle. Mol. Cell Biol. 13:1264-1272.
75. Von Knebel Doeberitz, M., C. Rittmüller, H. Zur Hausen, and M. Dürst. 1992. Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA. Int. J. Cancer 51:831-834.
76. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 proteins with p53. Science 248:76-79.
77. Yant, S. R., W. Zhu, D. Millinoff, J. L. Slightom, M. Goodman, and D. L. Gumucio. 1996. High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster. Nucleic Acids Res. 23:4353-4362.
78. Ye, J., X. Zhang, and Z. Dong. 1996. Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an AP1 complex and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complex. Mol. Cell. Biol. 16:157-167.
79. Zhou, Q., R. W. Gedrich, and D. A. Engel. 1995. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/ CREB. J. Virol. 69:4323-4330.
80. Zur Hausen, H. 1991. Human papillomavirus in the pathogenesis of anogenital cancer. Virology 184:9-13.