Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: Application to clinical pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 880, Issue 1, 2012, Pages 140-147

  De Moraes, Natália Valadares ^a   Lauretti, Gabriela Rocha ^a   Napolitano, Marcio Nogueira ^a   Santos, Naiane Ribeiro ^a   Godoy, Ana Leonor Pardo Campos ^a   Lanchote, Vera Lucia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Enantiomers; Fraction unbound; LC MS MS; Metabolites; Pharmacokinetics; Tramadol; Ultrafiltration

Indexed keywords

CHIRALPAK; CLINICAL APPLICATION; CLINICAL PHARMACOKINETICS; DETECTION SYSTEM; ENANTIOSELECTIVE; ENANTIOSELECTIVE ANALYSIS; FRACTION UNBOUND; HUMAN PLASMAS; LC-MS/MS; LIQUID/LIQUID EXTRACTION; LOWER LIMITS OF QUANTITATIONS; METHYL-T-BUTYL ETHERS; MULTIPLE REACTION MONITORING; NEUROPATHIC PAIN; O-DESMETHYLTRAMADOL; ORAL DOSE; PLASMA SAMPLES; POSITIVE ION MODE; REPRODUCIBILITIES; SAMPLE PREPARATION; TANDEM MASS SPECTROMETRY; TRAMADOL;

ELECTROSPRAY IONIZATION; ENANTIOMERS; ENANTIOSELECTIVITY; ETHERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHARMACOKINETICS; PLASMAS; SEPARATION; ULTRAFILTRATION;

CHIRALITY;

N DESMETHYLTRAMADOL; NARCOTIC ANALGESIC AGENT; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; ELECTROSPRAY; ENANTIOSELECTIVITY; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEUROPATHIC PAIN; PLASMA; PRIORITY JOURNAL; SINGLE DRUG DOSE; ULTRAFILTRATION;

ADULT; ANALGESICS, OPIOID; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; LIMIT OF DETECTION; LINEAR MODELS; MALE; MIDDLE AGED; NEURALGIA; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TRAMADOL; ULTRAFILTRATION;

EID: 84855189240     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.11.033     Document Type: Article

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