Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways

Neuroscience Letters

Volumn 507, Issue 1, 2012, Pages 38-42

  Liu, Ming Gang ^a   Lu, Dan ^a   Wang, Yan ^b   Chen, Xue Feng ^b   Li, Zhen ^b   Xu, Yan ^a   Jin, Jian Hui ^a   Wang, Rui Rui ^a,b   Chen, Jun ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Entorhinal hippocampal pathway; Metabotropic glutamate receptor; Multi electrode array; Persistent inflammatory pain state; Synaptic plasticity

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; AMPA RECEPTOR; BEE VENOM; DIMETHYL SULFOXIDE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5;

ARTICLE; BRAIN SLICE; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; NERVE CELL PLASTICITY; NOCICEPTION; NONHUMAN; PAIN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SPATIAL SYNAPTIC PLASTICITY; SYNAPTIC TRANSMISSION; TEMPORAL SYNAPTIC PLASTICITY;

ANIMALS; ENTORHINAL CORTEX; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; NEURAL PATHWAYS; NEURONAL PLASTICITY; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION;

EID: 84855187704     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.11.046     Document Type: Article

References (25)

1. 2+ signal transduction. J. Biol. Chem. 1992, 267:13361-13368.
2. Anwyl R. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res. Rev. 1999, 29:83-120.
3. Ben-Ari Y., Aniksztejn L. Role of glutamate metabotropic receptors in long-term potentiation in the hippocampus. Semin. Neurosci. 1995, 7:127-135.
4. Bortolotto Z.A., Fitzjohn S., Collingridge G.L. Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr. Opin. Neurobiol. 1999, 9:299-304.
5. Chen J., Lariviere R. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Prog. Neurobiol. 2010, 92:151-183.
6. Chen J., Luo C., Li H.L., Chen H.S. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test. Pain 1999, 83:67-76.
7. Conquet F., Bashir Z.I., Davies C.H., Daniel H., Ferraguti F., Bordi F., Franz-Bacon K., Reggiani A., Matarese V., Condé F., Collingridge G.L., Crépel F. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 1994, 372:237-243.
8. Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Veliçelebi G., Kuhn R. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 1999, 38:1493-1503.
9. Goudet C., Magnaghi V., Landry M., Nagy F., Gereau R.W., Pin J.P. Metabotropic receptors for glutamate and GABA in pain. Brain Res. Rev. 2009, 60:43-56.
10. Karim F., Wang C.C., Gereau R.W. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. 2001, 21:3771-3779.
11. Li J.Q., Chen S.R., Chen H., Cai Y.Q., Pan H.L. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J. Neurochem. 2010, 112:162-172.
12. Li Z., Ji G., Neugebauer V. Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. J. Neurosci. 2011, 31:1114-1127.
13. Litschig S., Asparini F., Rueegg D., Stoehr N., Flor P.J., Vranesic I., Prezaeu L., Pin J.P., Thomsen C., Kuhn R. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol. 1999, 55:453-461.
14. Liu M.G., Chen J. Role of the hippocampal formation in pain information processing. Neurosci. Bull. 2009, 25:237-266.
15. Liu M.G., Wang R.R., Chen X.F., Zhang F.K., Cui X.Y., Chen J. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings. Brain Res. 2011, 1382:57-69.
16. Lu Y.M., Jia Z.P., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., Roder J.C. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 1997, 17:5196-5205.
17. Luján R., Nusser Z., Roberts J.D., Shigemoto R., Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur. J. Neurosci. 1996, 8:488-1500.
18. Neugebauer V. Metabotropic glutamate receptors: novel targets for pain relief. Expert Rev. Neurother. 2001, 1:207-224.
19. Palazzo E., de Novellis V., Marabese I., Cuomo D., Rossi F., Berrino L., Rossi F., Maione S. Interaction between vanilloid and glutamate receptors in the central modulation of nociception. Eur. J. Pharmacol. 2002, 439:69-75.
20. Romano C., Sesma M.A., McDonald C.T., O'Malley K., Van den Pol A.N., Olney J.W. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J. Comp. Neurol. 1995, 355:455-469.
21. Salt T.E., Binns K.E. Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-d-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurons. Neuroscience 2000, 100:375-380.
22. Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. Comp. Neurol. 1992, 322:121-135.
23. Varney M.A., Gereau R.W. Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospect for the development of novel analgesics. Curr. Drug Targets CNS Neurol. Disord. 2002, 1:283-296.
24. Zhao X.Y., Liu M.G., Yuan D.L., Wang Y., He Y., Wang D.D., Chen X.F., Zhang F.K., Li H., He X.S., Chen J. Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording. Mol. Pain 2009, 5:55.
25. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.