Urinary hepcidin level as an early predictor of iron deficiency in children: A case control study

Italian Journal of Pediatrics

Volumn 37, Issue 1, 2011, Pages

  Sanad, Mohammed ^a   Gharib, Amal F ^b  

^a ZAGAZIG UNIVERSITY   (Egypt)

^b Zagazig University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEMOGLOBIN; HEPCIDIN; HEPCIDIN 25; IRON; PROTOPORPHYRIN ZINC; TRANSFERRIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BIOLOGICAL MARKER;

ADULT; ARTICLE; CASE CONTROL STUDY; CHILDHOOD DISEASE; CONTROLLED STUDY; CREATININE URINE LEVEL; DISEASE SEVERITY; EGYPT; ERYTHROPOIESIS; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HORMONE URINE LEVEL; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TRANSFERRIN SATURATION; BLOOD; COMPARATIVE STUDY; FOLLOW UP; METABOLISM; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SPECTROSCOPY; URINE;

ANEMIA, IRON-DEFICIENCY; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBINS; HUMANS; IRON; MALE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; ROC CURVE; SPECTRUM ANALYSIS;

EID: 84855186115     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: 10.1186/1824-7288-37-37     Document Type: Article

References (32)

1. Evaluation and treatment of iron deficiency Anemia: A gastroenterological perspective. Zhu A, Kaneshiro M, Kaunitz JD, Dig Dis Sci 2010 55 3 548 559 10.1007/s10620-009-1108-6 20108038
2. Prevention of Iron Deficiency in Infants and Toddlers. Kazal LA Jr, Am Fam Physician 2002 66 7 1217 1225 12387433
3. Behavior of infants with iron-deficiency anemia. Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME, Child Dev 1998 69 1 24 36 9499554 (Pubitemid 128453689)
4. Iron deficiency anemia: adverse effects on infant psychomotor development. Walter T, De Andraca I, Chadud P, Perales CG, Pediatrics 1989 84 1 7 17 2472596 (Pubitemid 19168032)
5. Iron metabolism. Beutler E, Fairbank VF, Williams Hematology New York: McGraw-Hill, Lichtman MA, Beutler E, Kaushansky K, Kipps T, Seligsohn U, Prchal J, 7 2006 chepter 24 295 305
6. Summary of a report on assessment of the iron nutritional status of the United States population. Expert Scientific Working Group, Am J Clin Nutr 1985 42 6 1318 1330 4072962
7. Diagnosis and management of iron-deficiency anemia. Cook JD, Best Pract Res Clin Haematol 2005 18 2 319 332 10.1016/j.beha.2004.08.022 15737893 (Pubitemid 40298373)
8. Significance of serum iron and ferritin in patients with colorectal adenomas. Kishida T, Shinozawa I, Tanaka S, Hoshino T, Tatsuguchi A, Feng L, Sato J, Fujimori S, Tachikawa H, Yamakado S, Tamagawa Y, Taguchi F, Yoshida Y, Kobayashi M, Scand J Gastroenterol 1997 32 3 233 237 10.3109/00365529709000200 9085460 (Pubitemid 27105298)
9. Soluble transferrin receptor and zinc protoporphyrin competitors or efficient partners? Metzgeroth G, Adelberger V, Dorn-Beineke A, Kuhn C, Schatz M, Maywald O, Bertsch T, Wisser H, Hehlmann R, Hastka J, Eur J Haematol 2005 75 4 309 317 10.1111/j.1600-0609.2005.00515.x 16146537 (Pubitemid 41297607)
10. Methods to assess iron and iodine status. Zimmermann MB, Br J Nutr 2008 99 Suppl 3 2 S9 Review 18598585
11. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S, Proc Natl Acad Sci USA 2001 98 15 8780 8785 10.1073/pnas.151179498 11447267 (Pubitemid 32678104)
12. Iron imports: IV. Hepcidin and regulation of body iron metabolism. Ganz T, Nemeth E, Am J Physiol Gastrointest Liver Physiol 2006 290 2 199 G203 10.1152/ajpgi.00412.2005 16407589
13. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Valore EV, Ganz T, Blood Cells Mol Dis 2008 40 1 132 138 10.1016/j.bcmd.2007.07.009 17905609 (Pubitemid 350192311)
14. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. Park CH, Valore EV, Waring AJ, Ganz T, J Biol Chem 2001 276 11 7806 7810 10.1074/jbc.M008922200 11113131
15. Immunoassay for human serum hepcidin. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M, Blood 2008 112 10 4292 4297 10.1182/blood-2008-02-139915 18689548
16. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels and hepatic function. Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O, Blood 2005 106 2 746 748 10.1182/blood-2004-12-4855 15797999 (Pubitemid 40981276)
17. An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees: A Cross-Sectional Study. Cherian S, Forbes D A, Cook A G, Sanfilippo F M, Kemna E H, Swinkels D W, Burgner DP, PLoS ONE 2008 3 12 4030 10.1371/journal.pone.0004030 19107209
18. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J, Science 2004 306 5704 2090 2093 10.1126/science.1104742 15514116 (Pubitemid 40007660)
19. Detection of serum hepcidin in renal failure and inflammation by using Protein Chip System. Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Umehara H, Ishikawa I, Blood 2006 108 4 1381 1387 10.1182/blood-2005-10-4043 16621968 (Pubitemid 44232041)
20. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T, Blood 2006 107 1 328 333 10.1182/blood-2005-05-2049 16141345 (Pubitemid 43053559)
21. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is over expressed during iron overload. Pigeon C, Ilyin G, Courselaud B, J Biol Chem 2001 276 11 7811 7819 10.1074/jbc. M008923200 11113132
22. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T, Blood 2007 110 6 2182 2189 10.1182/blood-2007-04-087593 17540841 (Pubitemid 47443938)
23. Suppression of hepcidin during anemia requires erythropoietic activity. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S, Blood 2006 108 12 3730 3735 10.1182/blood-2006-06-028787 16882706 (Pubitemid 44864551)
24. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T, Blood 2003 101 7 2461 2463 10.1182/blood-2002-10-3235 12433676 (Pubitemid 36857598)
25. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, Andrews NC, Blood 2007 109 9 4038 4044 10.1182/blood-2006-10-051755 17218383 (Pubitemid 46641759)
26. Amutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, Westerman M, Cazzola M, Galanello R, Haematologica 2008 93 10 1473 1479 10.3324/haematol.13342 18603562
27. Hereditary hemochromatosis. Pietrangelo A, Biochim Biophys Acta 2006 1763 7 700 710 10.1016/j.bbamcr.2006.05.013 16891003 (Pubitemid 44189549)
28. Hepcidin and iron-loading anemias. Nemeth E, Ganz T, Haematologica 2006 91 6 727 732 16769573 (Pubitemid 44014536)
29. Factors affecting iron balance. Conrad ME, Barton JC, Am J Hematol 1981 10 2 199 225 10.1002/ajh.2830100212 7015847 (Pubitemid 11047611)
30. Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias. Nemeth E, Adv Hematol 2010 2010 750643 20066043
31. Laboratory diagnosis of iron-deficiency anemia: an overview. Guyatt GH, Oxman AD, Ali M, Willan A, McIlroy W, Patterson C, J Gen Intern Med 1992 7 2 145 153 10.1007/BF02598003 1487761
32. Detecting iron deficiency in anemic patients with concomitant medical problems. Kis AM, Carnes M, J Gen Intern Med 1998 13 7 455 461 10.1046/j.1525-1497.1998.00134.x 9686711 (Pubitemid 28354289)