ELISA-based measurement of antibody responses and PCR-based detection profiles can distinguish between active infection and early clearance of Borrelia burgdorferi

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Lazarus, John J ^a   McCarter, Akisha L ^a   Neifer Sadhwani, Kari ^a   Wooten, R Mark ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL DNA; BORRELIA BURGDORFERI ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY;

ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; BACTERIUM DETECTION; BORRELIA BURGDORFERI; CONTROLLED STUDY; DNA REPAIR; ENZYME LINKED IMMUNOSORBENT ASSAY; HEATING; INNATE IMMUNITY; INOCULATION; LYME DISEASE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROCONVERSION; SEROLOGY; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; C57BL MOUSE; CHEMISTRY; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOLOGY; SKIN;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BORRELIA BURGDORFERI; DNA, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN G; LYME DISEASE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; SKIN;

EID: 84855162538     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/138069     Document Type: Article

References (66)

1. Burgdorfer W., Barbour A. G., Hayes S. F., Lyme diseaseA tick-borne spirochetosis? Science 1982 216 4552 1317 1319
2. Steere A. C., Coburn J., Glickstein L., The emergence of Lyme disease Journal of Clinical Investigation 2004 113 8 1093 1101 (Pubitemid 38544091)
3. Von Lackum K., Stevenson B., Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi FEMS Microbiology Letters 2005 243 1 173 179 (Pubitemid 40164404)
4. Barbour A. G., Isolation and cultivation of Lyme disease spirochetes Yale Journal of Biology and Medicine 1984 57 4 521 525 (Pubitemid 15151039)
5. Pollack R. J., Telford S. R., Spielman A., Standardization of medium for culturing Lyme disease spirochetes Journal of Clinical Microbiology 1993 31 5 1251 1255 (Pubitemid 23129454)
6. Fraser C. M., Casjens S., Huang W. M., Sutton G. G., Clayton R., Lathigra R., White O., Ketchum K. A., Dodson R., Hickey E. K., Gwinn M., Dougherty B., Tomb J. F., Fleischmann R. D., Richardson D., Peterson J., Kerlavage A. R., Quackenbush J., Salzberg S., Hanson M., Van Vugt R., Palmer N., Adams M. D., Gocayne J., Weidman J., Utterback T., Watthey L., McDonald L., Artiach P., Bowman C., Garland S., Fujii C., Cotton M. D., Horst K., Roberts K., Hatch B., Smith H. O., Venter J. C., Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi Nature 1997 390 6660 580 586 (Pubitemid 28016185)
7. Casjens S., Palmer N., Van Vugt R., Huang W. M., Stevenson B., Rosa P., Lathigra R., Sutton G., Peterson J., Dodson R. J., Haft D., Hickey E., Gwinn M., White O., Fraser C. M., A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi Molecular Microbiology 2000 35 3 490 516 (Pubitemid 30085269)
8. Barthold S. W., Lyme borreliosis in the laboratory mouse Journal of Spirochetal and Tick-borne Diseases 1996 3 22 44
9. Barthold S. W., De Souza M. S., Janotka J. L., Smith A. L., Persing D. H., Chronic lyme borreliosis in the laboratory mouse American Journal of Pathology 1993 143 3 959 972 (Pubitemid 24058251)
10. Ma Y., Seiler K. P., Eichwald E. J., Weis J. H., Teuscher C., Weis J. J., Distinct characteristics of resistance to Borrelia burgdorferi induced arthritis in C57BL/6N mice Infection and Immunity 1998 66 1 161 168
11. Hirschfeld M., Kirschning G. J., Schwandner R., Wesche H., Weis J. H., Wooten R. M., Weis J. J., Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2 Journal of Immunology 1999 163 5 2382 2386 (Pubitemid 29399155)
12. Wooten R. M., Ma Y., Yoder R. A., Brown J. P., Wei J. H., Zachary J. F., Kirschning C. J., Weis J. J., Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi Journal of Immunology 2002 168 1 348 355 (Pubitemid 34014136)
13. Bolz D. D., Sundsbak R. S., Ma Y., Akira S., Kirschning C. J., Zachary J. F., Weis J. H., Weis J. J., MyD88 plays a unique role in host defense but not arthritis development in lyme disease Journal of Immunology 2004 173 3 2003 2010 (Pubitemid 38971637)
14. Liu N., Montgomery R. R., Barthold S. W., Bockenstedt L. K., Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi -infected mice Infection and Immunity 2004 72 6 3195 3203 (Pubitemid 38697740)
15. Wooten R. M., Morrison T. B., Weis J. H., Wright S. D., Thieringer R., Weis J. J., The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Journal of Immunology 1998 160 11 5485 5492 (Pubitemid 28267840)
16. Benhnia M. R. E. I., Wroblewski D., Akhtar M. N., Patel R. A., Lavezzi W., Gangloff S. C., Goyert S. M., Caimano M. J., Radolf J. D., Sellati T. J., Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of lyme disease Journal of Immunology 2005 174 3 1539 1548
17. Brown J. P., Zachary J. F., Teuscher C., Weis J. J., Wooten R. M., Dual role of interleukin-10 in murine lyme disease: regulation of arthritis severity and host defense Infection and Immunity 1999 67 10 5142 5150 (Pubitemid 29455284)
18. Lazaras J. J., Meadows M. J., Lintner R. E., Wooten R. M., IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses Journal of Immunology 2006 177 10 7076 7085 (Pubitemid 44715075)
19. Xu Q., Seemanapalli S. V., Reif K. E., Brown C. R., Liang F. T., Increasing the recruitment of neutrophils to the site of infection dramatically attenuates Borrelia burgdorferi infectivity Journal of Immunology 2007 178 8 5109 5115 (Pubitemid 46595294)
20. Connolly S. E., Benach J. L., The versatile roles of antibodies in Borrelia infections Nature Reviews Microbiology 2005 3 5 411 420 (Pubitemid 40590383)
21. Barthold S. W., Bockenstedt L. K., Passive immunizing activity of sera from mice infected with Borrelia burgdorferi Infection and Immunity 1993 61 11 4696 4702 (Pubitemid 23320524)
22. Barthold S. W., DeSouza M., Feng S., Serum-mediated resolution of Lyme arthritis in mice Laboratory Investigation 1996 74 1 57 67 (Pubitemid 26041009)
23. De Silva A. M., Telford S. R., Brunet L. R. III, Barthold S. W., Fikrig E., Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine Journal of Experimental Medicine 1996 183 1 271 275 (Pubitemid 26028766)
24. Fikrig E., Barthold S. W., Kantor F. S., Flavell R. A., Protection of mice against the Lyme disease agent by immunizing with recombinant OspA Science 1990 250 4980 553 556 (Pubitemid 120031784)
25. Bockenstedt L. K., Fikrig E., Barthold S. W., Kantor F. S., Flavell R. A., Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice Journal of Immunology 1993 151 2 900 906 (Pubitemid 23215755)
26. Lawrenz M. B., Wooten R. M., Zachary J. F., Drouin S. M., Weis J. J., Wetsel R. A., Norris S. J., Effect of complement component C3 deficiency on experimental lyme borreliosis in mice Infection and Immunity 2003 71 8 4432 4440 (Pubitemid 36919909)
27. Morrison T. B., Weis J. J., Wittwer C. T., Quantification of lowcopy transcripts by continuous SYBR green I monitoring during amplification BioTechniques 1998 24 6 954 962 (Pubitemid 28275129)
28. Morrison T. B., Ma Y., Weis J. H., Weis J. J., Rapid and sensitive quantification of Borrelia burgdorferi -infected mouse tissues by continuous fluorescent monitoring of PCR Journal of Clinical Microbiology 1999 37 4 987 992 (Pubitemid 29140602)
29. Hodzic E., Feng S., Freet K. J., Borjesson D. L., Barthold S. W., Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface Infection and Immunity 2002 70 7 3382 3388 (Pubitemid 34665973)
30. Miller J. C., Von Lackum K., Babb K., McAlister J. D., Stevenson B., Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle Infection and Immunity 2003 71 12 6943 6952 (Pubitemid 37475325)
31. Liang F. T., Kenneth Nelson F., Fikrig E., Molecular adaptation of Borrelia burgdorferi in the murine host Journal of Experimental Medicine 2002 196 2 275 280 (Pubitemid 34787518)
32. Tokarz R., Anderton J. M., Katona L. I., Benach J. L., Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array Infection and Immunity 2004 72 9 5419 5432 (Pubitemid 39223430)
33. Setubal J. C., Reis M., Matsunaga J., Haake D. A., Lipoprotein computational prediction in spirochaetal genomes Microbiology 2006 152 1 113 121 (Pubitemid 43092399)
34. Aliprantis A. O., Yang R. B., Mark M. R., Suggett S., Devaux B., Radolf J. D., Klimpel G. R., Godowski P., Zychlinsky A., Cell activation and apoptosis by bacterial lipoproteins through Toll- like receptor-2 Science 1999 285 5428 736 739
35. Brightbill H. D., Libraty D. H., Krutzik S. R., Yang R. B., Belisle J. T., Bleharski J. R., Maitland M., Norgard M. V., Plevy S. E., Smale S. T., Brennan P. J., Bloom B. R., Godowski P. J., Modlin R. L., Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors Science 1999 285 5428 732 736
36. Lien E., Sellati T. J., Yoshimura A., Flo T. H., Rawadi G., Finberg R. W., Carroll J. D., Espevik T., Ingalls R. R., Radolf J. D., Golenbock D. T., Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products Journal of Biological Chemistry 1999 274 47 33419 33425 (Pubitemid 129511647)
37. Weis J. J., Ma Y., Erdile L. F., Biological activities of native and recombinant Borrelia burgdorferi outer surface protein A: dependence on lipid modification Infection and Immunity 1994 62 10 4632 4636 (Pubitemid 24302001)
38. Erdile L. F., Brandt M. A., Warakomski D. J., Westrack G. J., Sadziene A., Barbour A. G., Mays J. P., Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA Infection and Immunity 1993 61 1 81 90 (Pubitemid 23015402)
39. Ma Y., Sturrock A., Weis J. J., Intracellular localization of Borrelia burgdorferi within human endothelial cells Infection and Immunity 1991 59 2 671 678
40. Livengood J. A., Gilmore R. D., Invasion of human neuronal and glial cells by an infectious strain of Borrelia burgdorferi Microbes and Infection 2006 8 14-15 2832 2840 (Pubitemid 44914125)
41. Liang F. T., Brown E. L., Wang T., Iozzo R. V., Fikrig E., Protective niche for Borrelia burgdorferi to evade humoral immunity American Journal of Pathology 2004 165 3 977 985 (Pubitemid 39129304)
42. Cabello F. C., Godfrey H. P., Newman S. A., Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix Trends in Microbiology 2007 15 8 350 354 (Pubitemid 47126852)
43. Barthold S. W., Beck D. S., Hansen G. M., Terwilliger G. A., Moody K. D., Lyme borreliosis in selected strains and ages of laboratory mice Journal of Infectious Diseases 1990 162 1 133 138 (Pubitemid 20223961)
44. Belperron A. A., Bockenstedt L. K., Natural antibody affects survival of the spirochete Borrelia burgdorferi within feeding ticks Infection and Immunity 2001 69 10 6456 6462 (Pubitemid 32885211)
45. Woodman M. E., Cooley A. E., Miller J. C., Lazarus J. J., Tucker K., Bykowski T., Botto M., Hellwage J., Wooten R. M., Stevenson B., Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection Infection and Immunity 2007 75 6 3131 3139 (Pubitemid 46870199)
46. Schwan T. G., Piesman J., Temporal changes in outer surface proteins A and C of the lyme disease- associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice Journal of Clinical Microbiology 2000 38 1 382 388 (Pubitemid 30043321)
47. Schwan T. G., Piesman J., Golde W. T., Dolan M. C., Rosa P. A., Induction of an outer surface protein on Borrelia burgdorferi during tick feeding Proceedings of the National Academy of Sciences of the United States of America 1995 92 7 2909 2913
48. Stevenson B., Schwan T. G., Rosa P. A., Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi Infection and Immunity 1995 63 11 4535 4539
49. Barbour A. G., Tessier S. L., Todd W. J., Lyme disease spirochetes and Ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody Infection and Immunity 1983 41 2 795 804 (Pubitemid 13074639)
50. Schulze R. J., Zckert W. R., Borrelia burgdorferi lipoproteins are secreted to the outer surface by default Molecular Microbiology 2006 59 5 1473 1484
51. Keller D., Koster F. T., Marks D. H., Hosbach P., Erdile L. F., Mays J. P., Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine Journal of the American Medical Association 1994 271 22 1764 1768 (Pubitemid 24166615)
52. Erdile L. F., Bruno G., OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant Vaccine 1997 15 9 988 996 (Pubitemid 27308574)
53. Steere A. C., Sikand V. K., Meurice F., Parenti D. L., Fikrig E., Schoen R. T., Nowakowski J., Schmid C. H., Laukamp S., Buscarino C., Krause D. S., Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant New England Journal of Medicine 1998 339 4 209 215 (Pubitemid 28350162)
54. Barthold S. W., Sidman C. L., Smith A. L., Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency American Journal of Tropical Medicine and Hygiene 1992 47 5 605 613
55. Schaible U. E., Wallich R., Kramer M. D., Nerz G., Stehle T., Museteanu C., Simon M. M., Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone International Immunology 1994 6 5 671 681 (Pubitemid 24157648)
56. De Silva A. M., Fikrig E., Arthropod- and host-specific gene expression by Borrelia burgdorferi Journal of Clinical Investigation 1997 99 3 377 379 (Pubitemid 27414792)
57. Carroll J. A., Garon C. F., Schwan T. G., Effects of environmental pH on membrane proteins in Borrelia burgdorferi Infection and Immunity 1999 67 7 3181 3187 (Pubitemid 29291478)
58. Zhang J. R., Norris S. J., Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi Infection and Immunity 1998 66 8 3689 3697 (Pubitemid 28347825)
59. Simpson W. J., Schrumpf M. E., Schwan T. G., Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi Journal of Clinical Microbiology 1990 28 6 1329 1337 (Pubitemid 20194427)
60. Coleman J. L., Benach J. L., Identification and characterization of an endoflagellar antigen of Borrelia burgdorferi Journal of Clinical Investigation 1989 84 1 322 330 (Pubitemid 19170125)
61. Luft B. J., Mudri S., Jiang W., Dattwyler R. J., Gorevic P. D., Fischer T., Munoz P., Dunn J. J., Schubach W. H., The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen Infection and Immunity 1992 60 10 4309 4321
62. Pachner A. R., Basta J., Delaney E., Hulinska D., Localization of Borrelia burgdorferi in murine lyme borreliosis by electron microscopy American Journal of Tropical Medicine and Hygiene 1995 52 2 128 133
63. Zambrano M. C., Beklemisheva A. A., Bryksin A. V., Newman S. A., Cabello F. C., Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices Infection and Immunity 2004 72 6 3138 3146 (Pubitemid 38697734)
64. Guo B. P., Brown E. L., Dorward D. W., Rosenberg L. C., Hk M., Decorin-binding adhesins from Borrelia burgdorferi Molecular Microbiology 1998 30 4 711 723 (Pubitemid 28528591)
65. Haupl T., Hahn G., Rittig M., Krause A., Schoerner C., Schonherr U., Kalden J. R., Burmester G. R., Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis Arthritis and Rheumatism 1993 36 11 1621 1626 (Pubitemid 23327762)
66. Montgomery R. R., Nathanson M. H., Malawista S. E., The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages: destruction, survival, recovery Journal of Immunology 1993 150 3 909 915 (Pubitemid 23133670)