Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models

Neuroscience Letters

Volumn 289, Issue 1, 2000, Pages 29-32

  Charles, Vinod ^a   Mezey, Eva ^b   Reddy, P Hemachandra ^a   Dehejia, Anindya ^a   Young, Theresa A ^a   Polymeropoulos, Mihail H ^a   Brownstein, Michael J ^a,c   Tagle, Danilo A ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Synuclein; Cerebral cortex; Huntingtin; Huntington's disease; Immunohistochemistry; Parkinson's disease; Striatum; Transgenic mice

Indexed keywords

ALPHA SYNUCLEIN; HUNTINGTIN; MUTANT PROTEIN; POLYGLUTAMINE;

ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CASE REPORT; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALPHA-SYNUCLEIN; AMINO ACID MOTIFS; ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PHOSPHOPROTEINS; PROTEIN FOLDING; RABBITS; SYNUCLEINS;

EID: 0034726119     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01247-7     Document Type: Article

References (17)

1. Block-Galarza J., Chase K.O., Sapp E., Vaughn K.T., Vallee R.B., DiFiglia M., Aronin N. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. NeuroReport. 8:1997;2247-2251.
2. Cha J.H., Kosinski C.M., Kerner J.A., Alsdorf S.A., Mangiarini L., Davies S.W., Penney J.B., Bates G.P., Young A.B. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene. Proc. Natl. Acad. Sci. USA. 95:1998;6480-6485.
3. Clayton D.F., George J.M. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21:1998;249-254.
4. Furlong R.A., Narain Y., Rankin J., Wyttenbach A., Rubinsztein D.C. α-Synuclein overexpression promotes aggregation of mutant huntingtin. Biochem. J. 346:(3):2000;577-581.
5. Li H., Li S.H., Cheng A.L., Mangiarini L., Bates G.P., Li X.J. Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice. Hum. Mol. Genet. 8:1999;1227-1236.
6. Mezey E., Dehejia A.M., Harta G., Suchy S.F., Nussbaum R.L., Brownstein M.J., Polymeropoulos M.H. Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease. Mol. Psycholol. 3:1998;493-499.
7. Narain Y., Wyttenbach A., Rankin J., Furlong R.A., Rubinsztein D.C. A molecular investigation of true dominance in Huntington's disease. J. Med. Genet. 36:1999;739-746.
8. O'Kusky J.R., Nasir J., Cicchetti F., Parent A., Hayden M.R. Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene. Brain Res. 818:1999;468-479.
9. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
10. Reddy P.H., Charles V., Williams M., Miller G., Whetsell W.O. Jr., Tagle D.A. Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease. Philos. Trans. R. Soc. Lond. B Biol. Sci. 354:1999;1035-1045.
11. Reddy P.H., Williams M., Charles V., Garrett L., Pike-Buchanan L., Whetsell W.O. Jr., Miller G., Tagle D.A. Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length 1-ID cDNA. Nat. Genet. 20:1998;198-202.
12. Reddy P.H., Williams M., Tagle D.A. Recent advances in understanding the pathogenesis of Huntington's disease. Trends Neurosci. 22:1999;248-255.
13. Tukamoto T., Nukina N., Ide K., Kanazawa I. Huntington's disease gene product, huntingtin, associates with microtubules in vitro. Brain Res. Mol. Brain Res. 51:1997;8-14.
14. Usdin M.T., Shelbourne P.F., Myers R.M., Madison D.V. Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. Hum. Mol. Genet. 8:1999;839-846.
15. Velier J., Kim M., Schwarz C., Kim T.W., Sapp E., Chase K., Aronin N., Di Figlia M. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp. Neurol. 152:1998;34-40.
16. Wheeler V.C., White J.K., Gutekunst C.A., Vrbanac V., Weaver M., Li X.J., Li S.H., Yi H., Vonsattel J.P., Gusella J.F., Hersch S., Auerbach W., Joyner A.L., MacDonald M.E. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock- in mice. Hum. Mol. Genet. 9:2000;503-513.
17. Wood J.D., MacMillan J.C., Harper P.S., Lowenstein P.R., Jones A.L. Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Hum. Mol. Genet. 5:1996;481-487.