Slug inhibition upregulates radiation-induced PUMA activity leading to apoptosis in cholangiocarcinomas

Medical Oncology

Volumn 28, Issue SUPPL. 1, 2011, Pages

  Zhang, Kejun ^a   Zhang, Bingyuan ^a   Lu, Yun ^a   Sun, Chuandong ^a   Zhao, Wei ^a   Jiao, Xuelong ^a   Hu, Jilin ^a   Mu, Peng ^a   Lu, Hai ^a   Zhou, Changyong ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Apoptosis; p53 upregulated modulator of apoptosis; Radiation; Snail family transcription factor

Indexed keywords

MESSENGER RNA; PARVOVIRUS VECTOR; PUMA PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SLUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FEMALE; GAMMA IRRADIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; TREATMENT RESPONSE;

EID: 84655176658     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9759-x     Document Type: Article

References (57)

1. PC de Groen GJ Gores NF LaRusso LL Gunderson DM Nagorney 1999 Biliary tract cancers N Engl J Med 341 1368 1378
2. KN Lazaridis GJ Gores 2005 Cholangiocarcinoma Gastroenterology 128 1655 1667 (Pubitemid 40692558)
3. S Nair K Shiv Kumar PJ Thuluvath 2002 Mortality from hepatocellular and biliary cancers: changing epidemiological trends Am J Gastroenterol 97 167 171 (Pubitemid 34059782)
4. T Patel 2001 Increasing incidence and mortality of primary intrahepatic cholangio-carcinoma in the United States Hepatology 33 1353 1357 (Pubitemid 32496970)
5. MJ Olnes R Erlich 2004 A review and update on cholangiocarcinoma Oncology 66 167 179 (Pubitemid 38813042)
6. WR Jarnagin Y Fong RP DeMatteo 2001 Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma Ann Surg 234 507 517 discussion 517-519
7. H Witzigmann F Berr U Ringel 2006 Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma: palliative photodynamic therapy plus stenting is comparable to r1/r2 resection Ann Surg 244 230 239 (Pubitemid 44305537)
8. A Sasaki M Aramaki K Kawano 1998 Intrahepatic peripheral cholangiocarcinoma: mode of spread and choice of surgical treatment Br J Surg 85 1206 1209 (Pubitemid 28430419)
9. A Nakeeb HA Pitt TA Sohn 1996 Cholangiocarcinoma: a spectrum of intrahepatic, perihilar, and distal tumors Ann Surg 224 463 473 discussion 473-475
10. WK Washburn WD Lewis RL Jenkins 1995 Aggressive surgical resection for cholangiocarcinoma Arch Surg 130 270 276
11. T Patel P Singh 2007 Cholangiocarcinoma: emerging approaches to a challenging cancer Curr Opin Gastroenterol 23 317 323 (Pubitemid 46573149)
12. SB Reddy T Patel 2006 Current approaches to the diagnosis and treatment of cholangiocarcinoma Curr Gastroenterol Rep 8 30 37
13. SD Mansfield O Barakat RM Charnley 2005 Management of hilar cholangiocarcinoma in the North of England: pathology, treatment, and outcome World J Gastroenterol 11 7625 7630 (Pubitemid 43168427)
14. MW Wiedmann J Mössner 2010 Molecular targeted therapy of biliary tract cancer-results of the first clinical studies Curr Drug Targets 11 834 850
15. CD Briggs CP Neal CD Mann WP Steward MM Manson DP Berry 2009 Prognostic molecular markers in cholangiocarcinoma: a systematic review Eur J Cancer 45 33 47
16. L Coultas A Strasser 2000 The molecular control of DNA damage-induced cell death Apoptosis 5 491 507 (Pubitemid 32182547)
17. GJ He DD Sun DW Ji DM Sui FQ Yu QY Gao XW Dai H Gao T Jiang CL Dai 2008 Induction of biliary cholangiocarcinoma cell apoptosis by 103Pd cholangial radioactive stent gamma-rays Chin Med J (Engl) 121 1020 1024
18. S Yabuuchi Y Katayose A Oda M Mizuma S Shirasou T Sasaki K Yamamoto M Oikawa T Rikiyama T Onogawa H Yoshida H Ohtuska F Motoi S Egawa M Unno 2009 ZD1839 (IRESSA) stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines Anticancer Res 29 1169 1180
19. C Bianco G Tortora R Bianco R Caputo BM Veneziani R Caputo V Damiano T Troiani G Fontanini D Raben S Pepe AR Bianco F Ciardiello 2002 Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa) Clin Cancer Res 8 3250 3258 (Pubitemid 35155038)
20. MA Nieto 2002 The Snail superfamily of zinc finger transcription factors Nat Rev Mol Cell Biol 3 155 166
21. MA Ros M Sefton MA Nieto 1997 Slug, a zinc-finger gene previously implicated in the early patterning of the mesodermand the neural crest, is also involved in chick limb development Development 124 1821 1829 (Pubitemid 27248348)
22. P Savagner KM Yamada JP Thiery 1997 The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition J Cell Biol 137 1403 1419 (Pubitemid 27265951)
23. PB Gupta C Kuperwasser JP Brunet S Ramaswamy WL Kuo JW Gray SP Naber RA Weinberg 2005 The melanocyte differentiation program predisposes to metastasis after neoplastic transformation Nat Genet 37 1047 1054 (Pubitemid 41486656)
24. NK Kurrey SA Bapat 2005 Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level Gynecol Oncol 97 155 165 (Pubitemid 40403688)
25. TA Martin A Goyal G Watkins WG Jiang 2005 Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer Ann Surg Oncol 12 488 496 (Pubitemid 40884264)
26. PA Perez-Mancera I Gonzalez-Herrero M Perez-Caro N Gutierrez-Cianca T Flores A Gutierrez-Adan B Pintado M Sanchez-Martin I Sanchez-Garcia 2005 SLUG in cancer development Oncogene 24 3073 3082 (Pubitemid 40695076)
27. K Zhang D Wang S Zhang X Jiao C Li X Wang Q Yu H Cui 2010 The E-cadherin repressor slug and progression of human hilar cholangiocarcinoma J Exp Clin Cancer Res 1 29 88
28. KJ Zhang BY Zhang KP Zhang LM Tang SS Liu DM Zhu DL Zhang 2010 Clinicopathologic significance of slug expression in human intrahepatic cholangiocarcinoma World J Gastroenterol 16 2554 2557
29. K Hemavathy SI Ashraf YT Ip 2000 Snail/slug family of repressors: slowly going into the fast lane of development and cancer Gene 257 1 12
30. T Inukai A Inoue H Kurosawa 1999 SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein Mol Cell 4 343 352 (Pubitemid 29499787)
31. M Kajita KN [tmp] McClinic PA Wade 2004 Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress Mol Cell Biol 24 7559 7566 (Pubitemid 39121483)
32. M Kajita KN [tmp] McClinic PA Wade 2004 Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress Mol Cell Biol 24 7559 7566 (Pubitemid 39121483)
33. NK Kurrey SP Jalgaonkar AV Joglekar AD Ghanate PD Chaskar RY Doiphode SA Bapat 2009 Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells Stem Cells 27 2059 2068
34. A Cano MA Perez-Moreno I Rodrigo 2000 The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat Cell Biol 2 76 83
35. S Guaita I Puig C Franci 2002 Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression J Biol Chem 277 39209 39216 (Pubitemid 35190890)
36. HS Cha EK Bae JK Ahn J Lee KS Ahn EM Koh 2010 Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide Exp Mol Med 42 428 436
37. WS Wu S Heinrichs D Xu SP Garrison GP Zambetti JM Adams AT Look 2005 Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma Cell 123 641 653 (Pubitemid 41613746)
38. J Yu L Zhang 2003 No PUMA no death: implications for p53-dependent apoptosis Cancer Cell 4 248 249 (Pubitemid 37329788)
39. J Yu L Zhang PM Hwang KW Kinzler B Vogelstein 2001 PUMA induces the rapid apoptosis of colorectal cancer cells Mol Cell 7 673 682 (Pubitemid 32706358)
40. K Nakano KH Vousden 2001 PUMA, anovel proapoptotic gene, is induced by p53 Mol Cell 7 683 694 (Pubitemid 32706359)
41. J Han C Flemington AB Houghton 2001 Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals Proc Natl Acad Sci U S A 98 11318 11323 (Pubitemid 32928726)
42. J Yu Z Wang KW Kinzler B Vogelstein L Zhang 2003 PUMA mediates the apoptotic response to p53 in colorectal cancer cells Proc Natl Acad Sci U S A 100 1931 1936 (Pubitemid 36254551)
43. A Villunger EM Michalak L Coultas 2003 p 53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa Science 302 1036 1038 (Pubitemid 37386194)
44. JR Jeffers E Parganas Y Lee 2003 Puma is an essential mediator of p53-dependent and -independent apoptotic pathways Cancer Cell 4 321 328 (Pubitemid 37329796)
45. M Coureuil N Ugolin M Tavernier S Chevillard V Barroca P Fouchet I Allemand 2010 Puma and trail/dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors PLoS One 5 e12134
46. M Erlacher EM Michalak PN Kelly V Labi H Niederegger L Coultas JM Adams A Strasser A Villunger 2005 BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo Blood 106 4131 4138 (Pubitemid 41775918)
47. H Yu H Shen Y Yuan R XuFeng X Hu SP Garrison L Zhang J Yu GP Zambetti T Cheng 2010 Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation Blood 115 3472 3480
48. W Qiu EB Carson-Walter H Liu M Epperly JS Greenberger GP Zambetti L Zhang J Yu 2008 PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome Cell Stem Cell 2 576 583 (Pubitemid 351729214)
49. P Maier C Herskind WJ Zeller F Wenz 2009 SLUG as a novel radioprotector of normal tissue by gene transfer using a lentiviral bicistronic SIN vector Radiat Oncol 3 8174 8175
50. H Yang H Wan J Yu X Zhang L Zhang M Fu X Liang Q Zhan C Lin 2006 Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs Cancer Biol Ther 5 380 385
51. J Yu W Yue B Wu L Zhang 2006 PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation Clin Cancer Res 12 2928 2936
52. D Bacqueville P Deleris C Mendre 2001 Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei J Biol Chem 276 22170 22176
53. Zhang K, Zhang S, Jiao X, Wang H, Zhang D, Niu Z, Shen Y, Lv L, Zhou Y. Slug regulates proliferation and invasiveness of esophageal adenocarcinoma cells in vitro and vivo. Med Oncol. 2010.
54. S Haupt O Alsheich-Bartok Y Haupt 2006 Clues from worms: a Slug at Puma promotes the survival of blood progenitors Cell Death Differ 13 913 915
55. I Vannini M Bonafe A Tesei M Rosetti F Fabbri G Storci P Ulivi G Brigliadori D Amadori W Zoli 2007 Short interfering RNA directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustine Cell Oncol 29 279 287 (Pubitemid 47037248)
56. J Yu L Zhang 2008 PUMA, a potent killer with or without p53 Oncogene 27 Suppl 1 S71 S83
57. EM Michalak CJ Vandenberg AR Delbridge L Wu CL Scott JM Adams A Strasser 2010 Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death Genes Dev 24 1608 1613