In vitro and in vivo transdermal iontophoretic delivery of naloxone, an opioid antagonist

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 132-138

  Yamamoto, Rie ^a   Takasuga, Shinri ^a   Yoshida, Yoshimasa ^a   Mafune, Shoichi ^a   Kominami, Katsuya ^a   Sutoh, Chiyo ^a   Kato, Yukihiro ^a   Yamauchi, Mitsugu ^a   Ito, Masao ^a   Kanamura, Kiyoshi ^a   Kinoshita, Mine ^a  

^a TTI Ellebeau Inc   (Japan)

Author keywords

Iontophoresis; Naloxone hydrochloride; Opioid overdose; Pig; Rat; Transdermal

Indexed keywords

NALOXONE; SILVER; SILVER CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TISSUE LEVEL; EAR; ELECTRODE; FEASIBILITY STUDY; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; IONTOPHORETIC TRANSDERMAL PATCH; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SKIN; SKIN ABSORPTION; SKIN PERMEABILITY; STEADY STATE; SWINE; TRANSDERMAL PATCH;

ADMINISTRATION, CUTANEOUS; ANIMALS; ELECTRODES; EQUIPMENT DESIGN; FEASIBILITY STUDIES; IONTOPHORESIS; MALE; MODELS, BIOLOGICAL; NALOXONE; NARCOTIC ANTAGONISTS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SILVER COMPOUNDS; SKIN; SKIN ABSORPTION; SWINE; TRANSDERMAL PATCH;

EID: 84655170081     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.042     Document Type: Article

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