Tablet preformulations of indomethacin-loaded mesoporous silicon microparticles

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 125-131

  Tahvanainen, Maria ^a   Rotko, Tanja ^a   Mäkilä, Ermei ^b   A Santos, Hélder ^a   Neves, Diogo ^a   Laaksonen, Timo ^a   Kallonen, Aki ^a   Hämäläinen, Keijo ^a   Peura, Marko ^a   Serimaa, Ritva ^a   Salonen, Jarno ^b   Hirvonen, Jouni ^a   Peltonen, Leena ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Dissolution rate; Indomethacin; Mesoporous silicon; Microparticles; Poorly soluble drug; Tablet formulation

Indexed keywords

EXCIPIENT; INDOMETACIN;

ARTICLE; CELL STRAIN CACO 2; COMPRESSION; DISSOLUTION; DRUG RELEASE; HUMAN; HUMAN CELL; INTESTINE CELL; PERMEABILITY; PRIORITY JOURNAL; TABLET DISINTEGRATION TIME; TABLET FORMULATION; THICKNESS; WEIGHT;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; HUMANS; INDOMETHACIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; KINETICS; OXIDATION-REDUCTION; PARTICLE SIZE; PERMEABILITY; POROSITY; SILICON; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 84655163912     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.040     Document Type: Article

References (46)

1. G. Alderborn Tablets and compaction M.E. Aulton, Pharmaceutics. The Science of Dosage Form Design 2nd ed. 2002 Churchill Livingstone New York 397 440
2. L. Augsburger, and R. Shangraw Effects of glidants in tableting J. Pharm. Sci. 55 1966 418 423
3. E. Barrett, L. Joyner, and P. Halenda The determination of pore volume and area distributions in porous substances. I. Computations from nitrogen isotherms J. Am. Chem. Soc. 73 1951 373 380
4. S. Brunauer, P. Emmett, and E. Teller Adsorption of gases in multimolecular layers J. Am. Chem. Soc. 60 1938 309 319
5. J. Berryman Random close packing of hard spheres and disks Phys. Rev. A27 1983 1053 1061
6. L. Bimbo, M. Sarparanta, H.A. Santos, A. Airaksinen, E. Mäkilä, T. Laaksonen, L. Peltonen, V. Lehto, J. Hirvonen, and J. Salonen Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats ACS Nano 4 2010 3023 3032
7. L. Bimbo, E. Mäkilä, T. Laaksonen, V. Lehto, J. Salonen, J. Hirvonen, and H.A. Santos Drug permeation across intestinal epithelial cells using porous silicon nanoparticles Biomaterials 32 2011 2625 2633
8. C. Bhugra, R. Shmeis, and M. Pikal Role of mechanical stress in crystallization and relaxation behavior of amorphous indomethacin J. Pharm. Sci. 97 2008 4446 4458
9. R. Bodmeier Tableting of coated pellets Eur. J. Pharm. Biopharm. 43 1997 1 8 (Pubitemid 28298804)
10. J. Brouwers, M. Brewster, and P. Augustijns Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? J. Pharm. Sci. 98 2009 2549 2572
11. V. Bühler Polyvinylpyrrolidone Excipients for Pharmaceuticals 1st ed. 2005 Springer Berlin, Heidelberg/New York
12. Cabot Corporation Application of CAB-O-SIL® M-5P fumed silica in formulation and design of solid dosage form TD 149 2004 1 5
13. A. Cosjins, C. Vervaet, J. Luyten, S. Mullens, F. Siepmann, L. Van Hoorebeke, B. Masschaele, V. Cnudde, and J. Remon Porous hydroxyapatite tablets as carriers for low-doses drugs Eur. J. Pharm. Biopharm. 67 2007 498 506 (Pubitemid 47225041)
14. L. Gu, J. Park, K. Duong, E. Ruoslahti, and M. Sailor Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads Small 6 2010 2546 2552
15. P. Horcajada, A. Ramila, J. Perez-Pariente, and M.M. Vallet-Regi Influence of pore size of MCM-41 matrices on drug delivery rate Micropor. Mesopor. Mater. 68 2004 105 109 (Pubitemid 38265756)
16. A. Kaukonen, L. Laitinen, J. Salonen, J. Tuura, T. Heikkilä, T. Limnell, J. Hirvonen, and V. Lehto Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles Eur. J. Pharm. Biopharm. 66 2007 348 356 (Pubitemid 46756223)
17. E. Kerns, and L. Di Drug-like Properties: Concepts Structure Design and Methods: from ADME to Toxicity Optimization 1st ed. 2008 Academic Press, Elsevier Amsterdam
18. M. Koivisto, P. Heinänen, V. Tanninen, and V. Lehto Depth profiling of compression-induced disorders and polymorphic transition on tablet surfaces with grazing incidence X-ray diffraction Pharm. Res. 23 2006 813 820
19. M. Koljonen, K. Hakala, T. Ahtola-Sätilä, L. Laitinen, R. Kostiainen, T. Kotiaho, A. Kaukonen, and J. Hirvonen Evaluation of cocktail approach to standardise Caco-2 permeability experiments Eur. J. Pharm. Biopharm. 64 2006 379 387 (Pubitemid 44585212)
20. V. Lehto, K. Vähä-Heikkilä, J. Paski, and J. Salonen Use of thermoanalytical methods in quantification of drug load in mesoporous silicon microparticles Therm. Anal. Calorim. 80 2005 393 397 (Pubitemid 40626513)
21. C. Lerk, G. Bolhuis, and A. de Boer Comparative evaluation of excipients for direct compression. II Pharm. Weekblad 109 1974 945 955
22. T. Limnell, J. Riikonen, J. Salonen, A. Kaukonen, L. Laitinen, J. Hirvonen, and V. Lehto Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles Int. J. Pharm. 343 2007 141 147 (Pubitemid 47321019)
23. T. Limnell, H.A. Santos, E. Mäkilä, T. Heikkilä, J. Salonen, D. Murzin, K. Narenda, T. Laaksonen, L. Peltonen, and J. Hirvonen Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods J. Pharm. Sci. 100 2011 3294 3306
24. M. Manzano, M. Colilla, and M. Vallet-Regi Drug delivery from ordered mesoporous matrices Expert. Opin. Drug. Deliv. 6 2009 1383 1400
25. K. Morris, U. Griesser, C. Eckhardt, and J. Stowell Theoretical approaches to physical transformations of active pharmaceutical ingredients during manufacturing processes Adv. Drug Deliv. Rev. 48 2001 91 114 (Pubitemid 32452293)
26. G. Onoda, and E. Liniger Random loose packing of uniform spheres and the dilatancy effect Phys. Rev. Lett. 64 1990 2727 2730
27. C. Prestidge, T. Barnes, C. Lau, C. Barnett, A. Loni, and L. Canham Mesoporous silicon: a platform for the delivery of therapeutics Expert. Opin. Drug. Deliv. 4 2007 101 110 (Pubitemid 46389909)
28. J. Riikonen, E. Mäkilä, J. Salonen, and V. Lehto Determination of the physical state of drug molecules in mesoporous silicon with different surface chemistries Langmuir 25 2009 6137 6142
29. J. Salonen, A. Kaukonen, J. Hirvonen, and V. Lehto Mesoporous silicon in drug delivery applications J. Pharm. Sci. 97 2008 632 653 (Pubitemid 351293873)
30. J. Salonen, L. Laitinen, A. Kaukonen, J. Tuura, M. Björkqvist, T. Heikkilä, K. Vähä-Heikkilä, J. Hirvonen, and V. Lehto Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drug J. Control. Release 108 2005 362 374 (Pubitemid 41608668)
31. H.A. Santos, J. Riikonen, J. Salonen, E. Mäkilä, T. Heikkilä, T. Laaksonen, L. Peltonen, V. Lehto, and J. Hirvonen In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size Acta Biomater. 6 2010 2721 2731
32. H.A. Santos, J. Salonen, L. Bimbo, V. Lehto, L. Peltonen, and J. Hirvonen Mesoporous materials as controlled drug delivery formulations J. Drug Deliv. Sci. Technol. 21 2011 139 155
33. S. Safwat, A. Ali, M. Ahmed, and I. Sabour Effect of porous silica as drug carrier on the formulation of effervescent nystatin vaginal tablets Pharm. Ind. 57 1995 423 426
34. S. Sharma, P. Sher, S. Badve, and A. Pawar Adsorption of meloxicam on porous calcium silicate: characterization and tablet formulation AAPS Pharm. Sci. Technol. 6 2005 618 625
35. M. Vallet-Regi, F. Balas, and D. Arcos Mesoporous materials for drug delivery Angew. Chem. Int. Ed. 46 2007 7548 7558 (Pubitemid 47556998)
36. M. Vallet-Regi Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering Chem. Eur. J. 12 2006 5934 5943 (Pubitemid 44231020)
37. M. Vallet-Regi, A. Ramila, R. del Real, and J. Pérez-Pariente A new property of MCM-41: drug delivery system Chem. Mater. 13 2001 308 311 (Pubitemid 32199334)
38. K. van den Dries, and H. Vromans Relationship between inhomogeneity phenomena and granule growth mechanisms in a high-shear mixer Int. J. Pharm. 247 2002 167 177 (Pubitemid 35341148)
39. H. van Kamp, G. Bolhuis, and C. Lerk Optimization of a formulation based on lactoses for direct compression Acta Pharm. Technol. 34 1988 11 16
40. H. van Kamp, G. Bolhuis, and C. Lerk Studies on tableting properties of lactose, V. Effects of both lubrication and addition of disintegrants on properties of tablets prepared from different types of crystalline lactose Acta. Pharm. Suec. 23 1986 217 230 (Pubitemid 17198134)
41. M. Vialpando, A. Aerts, J. Persoons, J. Martens, and G. van den Mooter Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: influence of pressure on the structure and drug release J. Pharm. Sci., 100 2011 3411 3420
42. S. Vyazovkin, and I. Dranca Physical stability and relaxation of amorphous indomethacin J. Phys. Chem. B. 109 2005 18637 18644 (Pubitemid 41472062)
43. F. Wang, H. Hui, T. Barnes, C. Barnett, and C. Prestidge Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drug Mol. Pharm 7 2010 227 236
44. 1 from mesoporous silica tablets J. Control. Release 119 2007 215 221 (Pubitemid 46759558)
45. E. Wu, J.-H. Park, J. Park, E. Segal, F. Cunin, and M. Sailor Oxidation triggered release of fluorescent molecules or drugs from mesoporous Si microparticles ACS Nano 2 2008 2401 2409
46. M. Yoshioka, B. Hancock, and G. Zografi Crystallization of indomethacin from the amorphous state below and above its glass transition temperature J. Pharm. Sci. 83 1994 1700 1705