Relationship between inhomogeneity phenomena and granule growth mechanisms in a high-shear mixer

International Journal of Pharmaceutics

Volumn 247, Issue 1-2, 2002, Pages 167-177

  Van Den Dries, K ^a   Vromans, H ^a,b  

^a AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Demixing; Granulation; Granule strength; High shear mixer; Particle size; Porosity

Indexed keywords

ESTRADIOL; LACTOSE;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; DRUG DISTRIBUTION; PARTICLE SIZE; PRIORITY JOURNAL;

CHEMISTRY, PHARMACEUTICAL; PARTICLE SIZE; POROSITY; SHEAR STRENGTH; TECHNOLOGY, PHARMACEUTICAL;

EID: 0037168255     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00419-2     Document Type: Article

References (24)

1. Egermann H., Reiss W. Effect of particle size of drug and diluent on drug distribution in granule size fractions. Acta Pharm. Technol. 34:1988;5S.
2. Ennis B.J. A microlevel-based characterization of granulation phenomena. Powder Technol. 64:1991;257-272.
3. Ennis B.J., Li J.L., Tardos G.I., Pfeffer R. The influence of viscosity on the strength of an axially strained pendular liquid bridge. Chem. Eng. Sci. 45:1990;3071-3088.
4. Hapgood, K., 2000. Nucleation and binder dispersion in wet granulation. Ph.D. Thesis. The University of Queensland, Australia.
5. Hoornaert F., Wauters P.A.L., Meesters G.M.H., Pratsinis S.E., Scarlett B. Agglomeration behaviour of powders in a Lödige mixer granulator. Powder Technol. 96:1988;116-128.
6. Iveson S.M., Litster J.D. Fundamental studies of granule consolidation. Part 2. Quantifying the effects of particle and binder properties. Powder Technol. 99:1998;243-250.
7. Iveson S.M., Litster J.D. Growth regime map for liquid-bound granules. AIChE J. 44:1998;1510-1518.
8. Iveson S.M., Litster J.D. Liquid-bound granule impact deformation and coefficient of restitution. Powder Technol. 99:1998;234-242.
9. Iveson S.M., Litster J.D., Hapgood K., Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technol. 117:2001;3-39.
10. Iveson S.M., Wauters P.A.L., Forrest S., Litster J.D., Meesters G.M.H., Scarlett B. Growth regime map for liquid-bound granules: further development and experimental validation. Powder Technol. 117:2001;83-97.
11. Keningley S.T., Knight P.C., Marson A.D. An investigation into the effects of binder viscosity on agglomeration behaviour. Powder Technol. 91:1997;95-103.
12. Knight P.C., Instone T., Pearson J.M.K., Hounslow M.J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technol. 97:1988;246-257.
13. Leuenberger H., Bieri H.P., Sucker H. The theory of granulation liquid requirement in the conventional granulation process. Pharm. Technol. 3:1979;60-68.
14. Oijle J.E., Macfarlane C.B., Selkirk A.B. Drug distribution during massing and its effect on dose uniformity in granules. Int. J. Pharm. 10:1982;99-107.
15. Ritala M., Holm P., Schæfer T., Kristensen H.G. Influence of liquid bonding strength on power consumption during granulation in a high shear mixer. Drug Dev. Ind. Pharm. 14:1988;1041-1060.
16. Rumpf H. Grundlagen und methoden des granulieren. Chemie. Ing. Techn. 30:1958;144-158.
17. Rumpf H. The strength of granules and agglomerates. Knepper W.A., Agglomeration. 1962;379-418 Wiley, New York.
18. Scott A.C., Hounslow M.J., Instone T. Direct evidence of heterogeneity during high-shear granulation. Powder Technol. 113:2000;205-213.
19. Selkirk A.B. The effect of solute migration on the distribution of borax throughout a batch of granules. J. Pharm. Pharmacol. 28:1976;512-515.
20. Tardos G.I., Irfan Khan M., Mort P.R. Critical parameters and limiting conditions in binder granulation of fine powder. Powder Technol. 94:1997;245-258.
21. Vegt de, O., Oostra, W., Damen, M., Kok, S., Vromans, H. 2001. A study on the influence of process parameters of a high-shear granulation process on the composition of the resulting granules. In: Proceedings of PARTEC 2001, Nürnberg, Germany.
22. Vonk P., Guillaume C.P.F., Ramaker J.S., Vromans H., Kossen N.W.F. Growth mechanisms of high-shear pelletisation. Int. J. Pharm. 157:1997;93-102.
23. Vromans H., Poels-Janssen H.G.M., Egermann H. Effects of high-shear granulation on granulate homogeneity. Pharm. Dev. Technol. 4:1999;297-303.
24. Warren J.W. Jr., Price J.C. Drug migration during drying of tablet granulations. II. Effect of binder solution viscosity and drying temperature. J. Pharm. Sci. 66:1977;1409-1412.