Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes

Journal of Pharmaceutical Sciences

Volumn 93, Issue 10, 2004, Pages 2573-2584

  Patel, Mayank M ^a   Zeles, Michelle G ^b   Manning, Mark C ^a   Randolph, Theodore W ^b   Anchordoquy, Thomas J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UCB 450   (United States)

Author keywords

Cationic lipids (DOTAP); Ion pairing; Lactate DNA release kinetics; Matrix diffusion; Poly(L lactide) (PLLA); Polymer degradation

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; MICROSPHERE; PLASMID DNA; POLYLACTIDE;

ARTICLE; COMPLEX FORMATION; DEGRADATION KINETICS; DIFFUSION; ENCAPSULATION; EXPERIMENTAL MODEL; HYDROPHOBICITY; LIPID DEGRADATION; PRECIPITATION; STOICHIOMETRY;

EID: 4844221320     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20176     Document Type: Article

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