메뉴 건너뛰기




Volumn 821, Issue , 2012, Pages 29-44

Evaluation of the nutrient-sensing mTOR pathway

Author keywords

Cell survival; Growth factor; Kinase activity; mTOR; mTORC1; mTORC2; Nutrient; Phosphorylation; PI3 Kinase related kinase family

Indexed keywords

ANTIBODY; CRTC2 PROTEIN, HUMAN; MTORC1 COMPLEX, HUMAN; PROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

EID: 84555189447     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-430-8_3     Document Type: Article
Times cited : (6)

References (16)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger, S., Loewith, R., and Hall, M. N. (2006) TOR signaling in growth and metabolism, Cell 124, 471-484. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 3
    • 77953091045 scopus 로고    scopus 로고
    • Structure of the human mTOR complex i and its implications for rapamycin inhibition
    • Yip, C. K., Murata, K., Walz, T., Sabatini, D. M., and Kang, S. A. (2010) Structure of the human mTOR complex I and its implications for rapamycin inhibition, Mol Cell 38, 768-774.
    • (2010) Mol Cell , vol.38 , pp. 768-774
    • Yip, C.K.1    Murata, K.2    Walz, T.3    Sabatini, D.M.4    Kang, S.A.5
  • 4
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi, J., Chen, J., Schreiber, S. L., and Clardy, J. (1996) Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP, Science 273, 239-242. (Pubitemid 26285890)
    • (1996) Science , vol.273 , Issue.5272 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 5
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T., and Hall, M. N. (2000) TOR, a central controller of cell growth, Cell 103, 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 6
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictormTOR complex, Science 307, 1098-1101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 7
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • DOI 10.1038/nrc1974, PII NRC1974
    • Sabatini, D. M. (2006) mTOR and cancer: insights into a complex relationship, Nat Rev Cancer 6, 729-734. (Pubitemid 44286004)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 8
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell 110, 163-175. (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 12
    • 45849105156 scopus 로고    scopus 로고
    • The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • DOI 10.1126/science.1157535
    • Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., and Sabatini, D. M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1, Science 320, 1496-1501. (Pubitemid 351929429)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 14
    • 67649823420 scopus 로고    scopus 로고
    • Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein
    • Sato, T., Nakashima, A., Guo, L., and Tamanoi, F. (2009) Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein, J Biol Chem 284, 12783-12791.
    • (2009) J Biol Chem , vol.284 , pp. 12783-12791
    • Sato, T.1    Nakashima, A.2    Guo, L.3    Tamanoi, F.4
  • 15
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., and Sabatini, D. M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids, Cell 141, 290-303.
    • Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.