Thiadiazolidinones: A new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus

Biochemical Pharmacology

Volumn 83, Issue 3, 2012, Pages 368-377

  Ciustea, Mihai ^a   Mootien, Sara ^a   Rosato, Adriana E ^b   Perez, Oriana ^a   Cirillo, Pier ^a   Yeung, Kacheong R ^a   Ledizet, Michel ^a   Cynamon, Michael H ^c   Aristoff, Paul A ^a   Koski, Raymond A ^a   Kaplan, Paul A ^a   Anthony, Karen G ^a  

^a L2 Diagnostics LLC   (United States)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c SYRACUSE VA MEDICAL CENTER   (United States)

Author keywords

Alanine racemase; d Alanine; MRSA; Peptidoglycan

Indexed keywords

ANTIINFECTIVE AGENT; CYCLOSERINE; ISOMERASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROPIONATE SODIUM; PYRIDOXAL 5 PHOSPHATE; TROMETAMOL;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CELL PROLIFERATION; CLINICAL EVALUATION; CONTROLLED STUDY; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HELA CELL; HUMAN; HUMAN CELL; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS INFECTION;

ALANINE RACEMASE; ANTI-BACTERIAL AGENTS; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; THIADIAZOLES;

EID: 84455202288     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.11.021     Document Type: Article

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