Fate of mutation rate depends on agr locus expression during oxacillin-mediated heterogeneous-homogeneous selection in methicillin-resistant Staphylococcus aureus clinical strains

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 7, 2011, Pages 3176-3186

  Plata, Konrad B ^a   Rosato, Roberto R ^a   Rosato, Adriana E ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCESSORY GENE REGULATOR A PROTEIN; ACCESSORY GENE REGULATOR B PROTEIN; ACCESSORY GENE REGULATOR C PROTEIN; ACCESSORY GENE REGULATOR D PROTEIN; ACCESSORY GENE REGULATOR PROTEIN; ALPHA HEMOLYSIN; ARGININE DEAMINASE; AUTOLYSIN; BACTERIAL PROTEIN; BETA LACTAM; CHLORAMPHENICOL; IMMUNOGLOBULIN G BINDING PROTEIN A PRECURSOR PROTEIN; OXACILLIN; PEPTIDOGLYCAN HYDROLASE; RIFAMPICIN; SERINE PROTEASE SPLC; SERINE PROTEASE SPLE; SERINE PROTEASE V8 GLUTAMYL ENDOPEPTIDASE; STAPHYLOCOCCAL NUCLEASE; STAPHYLOCOCCUS TOXIN; TEICHOIC ACID TRANSLOCATION PERMEASE PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; DNA MICROARRAY; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUORUM SENSING;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; GENETIC COMPLEMENTATION TEST; GENOTYPE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXACILLIN; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79959219249     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01119-09     Document Type: Article

References (52)

1. Banerjee, R., M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers. 2008. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 52:2089-2096.
2. Boisset, S., et al. 2007. Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes Dev. 21:1353-1366. (Pubitemid 46871039)
3. Chakrabarti, S. K., and T. K. Misra. 2000. SarA represses agr operon expression in a purified in vitro Staphylococcus aureus transcription system. J. Bacteriol. 182:5893-5897.
4. Chambers, H. F., G. Archer, and M. Matsuhashi. 1989. Low-level methicillin resistance in strains of Staphylococcus aureus. Antimicrob. Agents Chemother. 33:424-428.
5. Cheung, A. L., and S. J. Projan. 1994. Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J. Bacteriol. 176:4168-4172.
6. Cirz, R. T., et al. 2007. Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. J. Bacteriol. 189:531-539. (Pubitemid 46106385)
7. Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S19, 19th informational supplement. CLSI, Wayne, PA.
8. Cui, L., J. Q. Lian, H. M. Neoh, E. Reyes, and K. Hiramatsu. 2005. DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 49:3404-3413.
9. Cuirolo, A., K. Plata, and A. E. Rosato. 2009. Development of homogeneous expression of resistance in methicillin-resistant Staphylococcus aureus clinical strains is functionally associated with a beta-lactam-mediated SOS response. J. Antimicrob. Chemother. 64:37-45.
10. Dunman, P. M., et al. 2001. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J. Bacteriol. 183:7341-7353. (Pubitemid 33121868)
11. Finan, J. E., A. E. Rosato, T. M. Dickinson, D. Ko, and G. L. Archer. 2002. Conversion of oxacillin-resistant staphylococci from heterotypic to homotypic resistance expression. Antimicrob. Agents Chemother. 46:24-30.
12. Forbes, B. A., et al. 2008. Unusual form of oxacillin resistance in methicillin-resistant Staphylococcus aureus clinical strains. Diagn. Microbiol. Infect. Dis. 61:387-395.
13. Frank, E. G., D. G. Ennis, M. Gonzalez, A. S. Levine, and R. Woodgate. 1996. Regulation of SOS mutagenesis by proteolysis. Proc. Natl. Acad. Sci.U. S. A. 93:10291-10296.
14. Gilot, P., G. Lina, T. Cochard, and B. Poutrel. 2002. Analysis of the genetic variability of genes encoding the RNA III-activating components Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis. J. Clin. Microbiol. 40:4060-4067.
15. Goldstein, F., et al. 2007. Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain. Antimicrob. Agents Chemother. 51:2514-2522.
16. Herold, B. C., et al. 1998. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 279:593-598. (Pubitemid 28110205)
17. Heyer, G., et al. 2002. Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect. Immun. 70:127-133.
18. Ingavale, S. S., W. van Wamel, and A. L. Cheung. 2003. Characterization of RAT, an autolysis regulator in Staphylococcus aureus. Mol. Microbiol. 48:1451-1466.
19. Ito, T., et al. 2001. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 45:1323-1336.
20. Janzon, L., and S. Arvidson. 1990. The role of the delta-lysin gene (hld) in the regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus. EMBO J. 9:1391-1399.
21. Katayama, Y., T. Ito, and K. Hiramatsu. 2000. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 44:1549-1555.
22. Kirby, W. M. 1944. Extraction of a highly potent pencilling inactivator from penicillin resistant staphylococci. Science 99:452-453.
23. Kuroda, M., K. Kuwahara-Arai, and K. Hiramatsu. 2000. Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method. Biochem. Biophys. Res. Commun. 269:485-490.
24. Kuroda, M., et al. 2001. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 357:1225-1240. (Pubitemid 32539050)
25. Lamichhane-Khadka, R., et al. 2009. sarA inactivation reduces vancomycin-intermediate and ciprofloxacin resistance expression by Staphylococcus aureus. Int. J. Antimicrob. Agents 34:136-141.
26. Layton, J. C., and P. L. Foster. 2003. Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli. Mol. Microbiol. 50:549-561.
27. Lina, G., et al. 1998. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol. Microbiol. 28:655-662.
28. Little, J. W. 1993. LexA cleavage and other self-processing reactions. J. Bacteriol. 175:4943-4950. (Pubitemid 23232553)
29. Luong, T. T., and C. Y. Lee. 2006. The arl locus positively regulates Staphylococcus aureus type 5 capsule via an mgrA-dependent pathway. Microbiology 152:3123-3131.
30. McKinney, T. K., V. K. Sharma, W. A. Craig, and G. L. Archer. 2001. Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and beta-lactamase regulators. J. Bacteriol. 183:6862-6868.
31. McNamara, P. J., K. C. Milligan-Monroe, S. Khalili, and R. A. Proctor. 2000. Identification, cloning, and initial characterization of rot, a locus encoding a regulator of virulence factor expression in Staphylococcus aureus. J. Bacteriol. 182:3197-3203.
32. Miller, C., et al. 2004. SOS response induction by beta-lactams and bacterial defense against antibiotic lethality. Science 305:1629-1631. (Pubitemid 39296359)
33. Mongodin, E., et al. 2003. Microarray transcription analysis of clinical Staphylococcus aureus isolates resistant to vancomycin. J. Bacteriol. 185:4638-4643. (Pubitemid 36890515)
34. Morfeldt, E., L. Janzon, S. Arvidson, and S. Lofdahl. 1988. Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus. Mol. Gen. Genet. 211:435-440.
35. Morfeldt, E., I. Panova-Sapundjieva, B. Gustafsson, and S. Arvidson. 1996. Detection of the response regulator AgrA in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies. FEMS Microbiol. Lett. 143:195-201.
36. Novick, R. 1967. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33:155-166.
37. Novick, R. P., and E. Geisinger. 2008. Quorum sensing in staphylococci. Annu. Rev. Genet. 42:541-564.
38. Novick, R. P., et al. 1993. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 12:3967-3975. (Pubitemid 23282772)
39. Peng, H. L., R. P. Novick, B. Kreiswirth, J. Kornblum, and P. Schlievert. 1988. Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J. Bacteriol. 170:4365-4372.
40. Perez-Capilla, T., et al. 2005. SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli. J. Bacteriol. 187:1515-1518. (Pubitemid 40299476)
41. Queck, S. Y., et al. 2008. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol. Cell 32:150-158.
42. Recsei, P., et al. 1986. Regulation of exoprotein gene expression in Staphylococcus aureus by agar. Mol. Gen. Genet. 202:58-61.
43. Romby, P., F. Vandenesch, and E. G. Wagner. 2006. The role of RNAs in the regulation of virulence-gene expression. Curr. Opin. Microbiol. 9:229-236.
44. Said-Salim, B., et al. 2003. Global regulation of Staphylococcus aureus genes by Rot. J. Bacteriol. 185:610-619. (Pubitemid 36070488)
45. Sakoulas, G., et al. 2002. Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob. Agents Chemother. 46:1492-1502.
46. Tattevin, P., L. Basuino, and H. F. Chambers. 2009. Subinhibitory fluoroquinolone exposure selects for reduced beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus and alterations in the SOS-mediated response. Res. Microbiol. 160:187-192.
47. Tenaillon, O., E. Denamur, and I. Matic. 2004. Evolutionary significance of stress-induced mutagenesis in bacteria. Trends Microbiol. 12:264-270. (Pubitemid 38686374)
48. Toledo-Arana, A., F. Repoila, and P. Cossart. 2007. Small noncoding RNAs controlling pathogenesis. Curr. Opin. Microbiol. 10:182-188.
49. Tomasz, A., S. Nachman, and H. Leaf. 1991. Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci. Antimicrob. Agents Chemother. 35:124-129.
50. van den Broek, D., A. W. T. Chin, G. V. Bloemberg, and B. J. Lugtenberg. 2005. Role of RpoS and MutS in phase variation of Pseudomonas sp. PCL1171. Microbiology 151:1403-1408.
51. Walsh, T. R., and R. A. Howe. 2002. The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus. Annu. Rev. Microbiol. 56:657-675.
52. Zhang, L., L. Gray, R. P. Novick, and G. Ji. 2002. Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus. J. Biol. Chem. 277:34736-34742.