Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

Drug Metabolism and Disposition

Volumn 40, Issue 1, 2012, Pages 104-110

  Zanelli, Ugo ^a   Caradonna, Nicola Pasquale ^a   Hallifax, David ^b   Turlizzi, Elisa ^a   Houston, J Brian ^b  

^a Siena Biotech SpA   (Italy)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRENOLOL; BUFURALOL; CAFFEINE; CHLORPROMAZINE; CLOMIPRAMINE; CYTOCHROME P450; DICLOFENAC; DOMPERIDONE; FENOPROFEN; FLUPHENAZINE; FLURBIPROFEN; FUROSEMIDE; GLIBENCLAMIDE; GLIMEPIRIDE; IBUPROFEN; IMIPRAMINE; KETOPROFEN; LABETALOL; LIDOCAINE; METHYLPREDNISOLONE; METOPROLOL; MIANSERIN; NAPROXEN; NIFEDIPINE; PHENACETIN; PHENAZONE; PREDNISOLONE; PROCHLORPERAZINE; PROMAZINE; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG CLEARANCE; HUMAN; HUMAN CELL; LIVER CELL; LIVER CLEARANCE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

CELL LINE, TUMOR; CRYOPRESERVATION; FEMALE; HEPATOCYTES; HUMANS; MALE; METABOLIC CLEARANCE RATE; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS;

EID: 84455174579     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042309     Document Type: Article

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