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Volumn 81, Issue 1, 2012, Pages 73-85

Tyrosine phosphorylation of the human serotonin transporter: A role in the transporter stability and function

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; MUTANT PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SEROTONIN; SEROTONIN TRANSPORTER; SMALL INTERFERING RNA; TYROSINE;

EID: 84455170361     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073171     Document Type: Article
Times cited : (21)

References (41)
  • 2
    • 0000358207 scopus 로고
    • Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs
    • Bloom FE and Kupfer DJ eds Raven Press, New York
    • Barker EL and Blakely RD (1995) Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs, in Psychopharmacology: The Fourth Generation of Progress (Bloom FE and Kupfer DJ eds) pp 321-333, Raven Press, New York.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 321-333
    • Barker, E.L.1    Blakely, R.D.2
  • 3
    • 0034667557 scopus 로고    scopus 로고
    • Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A
    • Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, and Blakely RD (2000) Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 20:7571-7578.
    • (2000) J Neurosci , vol.20 , pp. 7571-7578
    • Bauman, A.L.1    Apparsundaram, S.2    Ramamoorthy, S.3    Wadzinski, B.E.4    Vaughan, R.A.5    Blakely, R.D.6
  • 4
    • 0031978809 scopus 로고    scopus 로고
    • Altered brain serotonin homeostasis and locomotor insensitivity to 3,4- methylenedioxymethamphetamine ('ecstasy') in serotonin transporter-deficient mice
    • Bengel D, Murphy DL, Andrews AM, Wichems CH, Feltner D, Heils A, Mössner R, Westphal H, and Lesch KP (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymetamphetamine ("ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol 53:649-655. (Pubitemid 28196486)
    • (1998) Molecular Pharmacology , vol.53 , Issue.4 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5    Heils, A.6    Mossner, R.7    Westphal, H.8    Lesch, K.-P.9
  • 6
    • 0011887836 scopus 로고
    • Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virus
    • DOI 10.1073/pnas.78.4.2388
    • Cheng YS and Chen LB (1981) Detection of phosphotyrosine-containing 34,000- dalton protein in the framework of cells transformed with Rous sarcoma virus. Proc Natl Acad Sci USA 78:2388-2392. (Pubitemid 11119834)
    • (1981) Proceedings of the National Academy of Sciences of the United States of America , vol.78 , Issue.4 II , pp. 2388-2392
    • Cheng, Y.S.E.1    Chen, L.B.2
  • 7
    • 50849144837 scopus 로고    scopus 로고
    • Calcium/calmodulindependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A
    • Ciccone MA, Timmons M, Phillips A, and Quick MW (2008) Calcium/calmodulindependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A. Neuropharmacology 55:763-770.
    • (2008) Neuropharmacology , vol.55 , pp. 763-770
    • Ciccone, M.A.1    Timmons, M.2    Phillips, A.3    Quick, M.W.4
  • 8
    • 0033792180 scopus 로고    scopus 로고
    • 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo
    • Daws LC, Gould GG, Teicher SD, Gerhardt GA, and Frazer A (2000) 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo. J Neurochem 75:2113-2122.
    • (2000) J Neurochem , vol.75 , pp. 2113-2122
    • Daws, L.C.1    Gould, G.G.2    Teicher, S.D.3    Gerhardt, G.A.4    Frazer, A.5
  • 9
    • 0033807807 scopus 로고    scopus 로고
    • Transport rates of GABA transporters: Regulation by the N-terminal domain and syntaxin 1A
    • Deken SL, Beckman ML, Boos L, and Quick MW (2000) Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A. Nat Neurosci 3:998-1003.
    • (2000) Nat Neurosci , vol.3 , pp. 998-1003
    • Deken, S.L.1    Beckman, M.L.2    Boos, L.3    Quick, M.W.4
  • 13
    • 0029053978 scopus 로고
    • Tyrosine kinase inhibitors regulate serotonin uptake in platelets
    • Helmeste DM and Tang SW (1995) Tyrosine kinase inhibitors regulate serotonin uptake in platelets. Eur J Pharmacol 280:R5-R7.
    • (1995) Eur J Pharmacol , vol.280
    • Helmeste, D.M.1    Tang, S.W.2
  • 14
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC
    • Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 15
    • 0028200186 scopus 로고
    • Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells
    • Jayanthi LD, Ramamoorthy S, Mahesh VB, Leibach FH, and Ganapathy V (1994) Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J Biol Chem 269:14424-14429. (Pubitemid 24193993)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.20 , pp. 14424-14429
    • Jayanthi, L.D.1    Ramamoorthy, S.2    Mahesh, V.B.3    Leibach, F.H.4    Ganapathy, V.5
  • 16
    • 21744442114 scopus 로고    scopus 로고
    • Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation
    • DOI 10.1124/mol.104.009555
    • Jayanthi LD, Samuvel DJ, Blakely RD, and Ramamoorthy S (2005) Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Mol Pharmacol 67:2077-2087. (Pubitemid 41007790)
    • (2005) Molecular Pharmacology , vol.67 , Issue.6 , pp. 2077-2087
    • Jayanthi, L.D.1    Samuvel, D.J.2    Blakely, R.D.3    Ramamoorthy, S.4
  • 17
    • 0030934369 scopus 로고    scopus 로고
    • Human serotonin transporter: Regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor
    • Kekuda R, Torres-Zamorano V, Leibach FH, and Ganapathy V (1997) Human serotonin transporter: Regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor. J Neurochem 68:1443-1450. (Pubitemid 27133051)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.4 , pp. 1443-1450
    • Kekuda, R.1    Torres-Zamorano, V.2    Leibach, F.H.3    Ganapathy, V.4
  • 20
    • 0032938716 scopus 로고    scopus 로고
    • Regulation of tyrosine kinase cascades by G-protein-coupled receptors
    • DOI 10.1016/S0955-0674(99)80023-4
    • Luttrell LM, Daaka Y, and Lefkowitz RJ (1999) Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11:177-183. (Pubitemid 29164031)
    • (1999) Current Opinion in Cell Biology , vol.11 , Issue.2 , pp. 177-183
    • Luttrell, L.M.1    Daaka, Y.2    Lefkowitz, R.J.3
  • 21
    • 0035840320 scopus 로고    scopus 로고
    • Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
    • DOI 10.1016/S0169-328X(01)00183-8, PII S0169328X01001838
    • Madhav TR, Pei Q, and Zetterström TS (2001) Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF). Brain Res Mol Brain Res 93:56-63. (Pubitemid 32786902)
    • (2001) Molecular Brain Research , vol.93 , Issue.1 , pp. 56-63
    • Madhav, T.R.1    Pei, Q.2    Zetterstrom, T.S.C.3
  • 22
    • 79957973802 scopus 로고    scopus 로고
    • Cocaine upregulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase
    • Mannangatti P, Arapulisamy O, Shippenberg TS, Ramamoorthy S, and Jayanthi LD (2011) Cocaine upregulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase. J Biol Chem 286: 20239-20250.
    • (2011) J Biol Chem , vol.286 , pp. 20239-20250
    • Mannangatti, P.1    Arapulisamy, O.2    Shippenberg, T.S.3    Ramamoorthy, S.4    Jayanthi, L.D.5
  • 23
    • 2342629856 scopus 로고    scopus 로고
    • Serotonin transporter: Gene, genetic disorders, and pharmacogenetics
    • DOI 10.1124/mi.4.2.8
    • Murphy DL, Lerner A, Rudnick G, and Lesch KP (2004) Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv 4:109-123. (Pubitemid 38584973)
    • (2004) Molecular Interventions , vol.4 , Issue.2 , pp. 109-123
    • Murphy, D.L.1    Lerner, A.2    Rudnick, G.3    Lesch, K.-P.4
  • 25
    • 0023668454 scopus 로고
    • Phosphorylation of the lysosomal enzyme binding receptor protein from monkey brain and evidence for a tyrosine kinase activity associated with it
    • Panneerselvam K, Ramamoorthy S, and Balasubramanian AS (1987) Phosphorylation of the lysosomal enzyme binding receptor protein from monkey brain and evidence for a tyrosine kinase activity associated with it. Biochem Biophys Res Commun 147:927-935.
    • (1987) Biochem Biophys Res Commun , vol.147 , pp. 927-935
    • Panneerselvam, K.1    Ramamoorthy, S.2    Balasubramanian, A.S.3
  • 27
    • 0030964057 scopus 로고    scopus 로고
    • Functional link between tyrosine phosphorylation and human serotonin transporter gene expression
    • DOI 10.1016/S0014-2999(97)00100-3, PII S0014299997001003
    • Prasad PD, Torres-Zamorano V, Kekuda R, Leibach FH, and Ganapathy V (1997) Functional link between tyrosine phosphorylation and human serotonin transporter gene expression. Eur J Pharmacol 325:85-92. (Pubitemid 27190460)
    • (1997) European Journal of Pharmacology , vol.325 , Issue.1 , pp. 85-92
    • Prasad, P.D.1    Torres-Zamorano, V.2    Kekuda, R.3    Leibach, F.H.4    Ganapathy, V.5
  • 28
    • 0345119042 scopus 로고    scopus 로고
    • Regulating the conducting states of a mammalian serotonin transporter
    • Quick MW (2003) Regulating the conducting states of a mammalian serotonin transporter. Neuron 40:537-549.
    • (2003) Neuron , vol.40 , pp. 537-549
    • Quick, M.W.1
  • 29
  • 31
    • 0033618638 scopus 로고    scopus 로고
    • Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
    • Ramamoorthy S and Blakely RD (1999) Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285:763-766.
    • (1999) Science , vol.285 , pp. 763-766
    • Ramamoorthy, S.1    Blakely, R.D.2
  • 32
    • 0027364837 scopus 로고
    • Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding
    • Ramamoorthy S, Cool DR, Mahesh VB, Leibach FH, Melikian HE, Blakely RD, and Ganapathy V (1993b) Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. J Biol Chem 268:21626-21631. (Pubitemid 23320655)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.29 , pp. 21626-21631
    • Ramamoorthy, S.1    Cool, D.R.2    Mahesh, V.B.3    Leibach, F.H.4    Melikian, H.E.5    Blakely, R.D.6    Ganapathy, V.7
  • 33
    • 0031915461 scopus 로고    scopus 로고
    • Phosphorylation and regulation of antidepressant-sensitive serotonin transporters
    • DOI 10.1074/jbc.273.4.2458
    • Ramamoorthy S, Giovanetti E, Qian Y, and Blakely RD (1998) Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. J Biol Chem 273: 2458-2466. (Pubitemid 28069306)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.4 , pp. 2458-2466
    • Ramamoorthy, S.1    Giovanetti, E.2    Qian, Y.3    Blakely, R.D.4
  • 34
    • 34249678451 scopus 로고    scopus 로고
    • Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP
    • DOI 10.1074/jbc.M611353200
    • Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G, and Jayanthi LD (2007) Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. J Biol Chem 282:11639-11647. (Pubitemid 47100698)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 11639-11647
    • Ramamoorthy, S.1    Samuvel, D.J.2    Buck, E.R.3    Rudnick, G.4    Jayanthi, L.D.5
  • 35
    • 79151476913 scopus 로고    scopus 로고
    • Regulation of monoamine transporters: Role of transporter phosphorylation
    • Ramamoorthy S, Shippenberg TS, and Jayanthi LD (2011) Regulation of monoamine transporters: Role of transporter phosphorylation. Pharmacol Ther 129:220-238.
    • (2011) Pharmacol Ther , vol.129 , pp. 220-238
    • Ramamoorthy, S.1    Shippenberg, T.S.2    Jayanthi, L.D.3
  • 36
    • 12144279565 scopus 로고    scopus 로고
    • A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: Evidence for distinct cellular mechanisms involved in transporter surface expression
    • DOI 10.1523/JNEUROSCI.3754-04.2005
    • Samuvel DJ, Jayanthi LD, Bhat NR, and Ramamoorthy S (2005) A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci 25:29-41. (Pubitemid 40110763)
    • (2005) Journal of Neuroscience , vol.25 , Issue.1 , pp. 29-41
    • Samuvel, D.J.1    Jayanthi, L.D.2    Bhat, N.R.3    Ramamoorthy, S.4
  • 38
    • 0033546936 scopus 로고    scopus 로고
    • Serotonin transporter production and degradation rates: Studies with RTI-76
    • DOI 10.1016/S0006-8993(99)01761-8, PII S0006899399017618
    • Vicentic A, Battaglia G, Carroll FI, and Kuhar MJ (1999) Serotonin transporter production and degradation rates: studies with RTI-76. Brain Res 841:1-10. (Pubitemid 29440994)
    • (1999) Brain Research , vol.841 , Issue.1-2 , pp. 1-10
    • Vicentic, A.1    Battaglia, G.2    Ivy, C.F.3    Kuhar, M.J.4
  • 39
    • 38349183667 scopus 로고    scopus 로고
    • Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT
    • Zarpellon A, Donella-Deana A, Folda A, Turetta L, Pavanetto M, and Deana R (2008) Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT. Cell Physiol Biochem 21:87-94.
    • (2008) Cell Physiol Biochem , vol.21 , pp. 87-94
    • Zarpellon, A.1    Donella-Deana, A.2    Folda, A.3    Turetta, L.4    Pavanetto, M.5    Deana, R.6
  • 40
    • 35148853625 scopus 로고    scopus 로고
    • Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive-compulsive disorder
    • DOI 10.1523/JNEUROSCI.0034-07.2007
    • Zhang YW, Gesmonde J, Ramamoorthy S, and Rudnick G (2007) Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder. J Neurosci 27:10878-10886. (Pubitemid 47535855)
    • (2007) Journal of Neuroscience , vol.27 , Issue.40 , pp. 10878-10886
    • Zhang, Y.-W.1    Gesmonde, J.2    Ramamoorthy, S.3    Rudnick, G.4
  • 41
    • 2442650231 scopus 로고    scopus 로고
    • Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation
    • DOI 10.1124/mol.65.6.1462
    • Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, and Blakely RD (2004) Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol Pharmacol 65:1462-1474. (Pubitemid 38668304)
    • (2004) Molecular Pharmacology , vol.65 , Issue.6 , pp. 1462-1474
    • Zhu, C.-B.1    Hewlett, W.A.2    Feoktistov, I.3    Biaggioni, I.4    Blakely, R.D.5


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