Human serotonin transporter: Regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor

Journal of Neurochemistry

Volumn 68, Issue 4, 1997, Pages 1443-1450

  Kekuda, Ramesh ^a   Torres Zamorano, Viviana ^a   Leibach, Frederick H ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Aurintricarboxylic acid; Epidermal growth factor; Human placenta; JAR cells; Serotonin transporter

Indexed keywords

AURINTRICARBOXYLIC ACID; CARRIER PROTEIN; EPIDERMAL GROWTH FACTOR;

ARTICLE; CANCER CELL CULTURE; CHORIOCARCINOMA; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MICHAELIS CONSTANT; NEUROPROTECTION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; PROTEIN TRANSPORT;

EID: 0030934369     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68041443.x     Document Type: Article

References (27)

1. Anderson G. M. and Horne W. C. (1992) Activators of protein kinase C decrease serotonin transport in human platelets. Biochim. Biophys. Acta 1137, 331-337.
2. Balkovetz D. F., Tiruppathi C., Leibach F. H., Mahesh V. B., and Ganapathy V. (1989) Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J. Biol. Chem. 264, 2195-2198.
3. Batistatou A. and Greene L. A. (1991) Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol. 115, 461-471.
4. Batistatou A. and Greene L. A. (1993) Intranucleosomal DNA cleavage and neuronal cell survival/death. J. Cell Biol. 122, 523-532.
5. Carson S. A., Chase R., Ulep E., Scommegna A., and Benveniste R. (1983) Ontogenesis and characteristics of epidermal growth factor receptors in human placenta. Am. J. Obstet. Gynecol. 147, 932-939.
6. Chen C. F., Kurachi H., Fujita Y., Terakawa N., Miyake A., and Tanizawa O. (1988) Changes in epidermal growth factor receptor and its messenger ribonucleic acid levels in human placenta and isolated trophoblast cells during pregnancy. J. Clin. Endocrinol. Metab. 67, 1171-1177.
7. Cool D. R., Leibach F. H., Bhalla V. K., Mahesh V. B., and Ganapathy V. (1991) Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). J. Biol. Chem. 266, 15750-15757.
8. Ganapathy V. and Leibach F. H. (1994) Human placenta: a direct target for cocaine action. Placenta 15, 785-795.
9. Ganapathy V. and Leibach F. H. (1995) Placental biogenic amines and their transporters, in Placental Toxicology (Rama Sastry B. V., ed), pp. 161-174. CRC Press, Boca Raton, Florida.
10. Ganapathy V., Kulanthaivel P., Tiruppathi C., Mahesh V. B., and Leibach F. H. (1989) Inactivation of the human placental serotonin transporter by tyrosyl group-specific reagents. J. Pharmacol. Exp. Ther. 251, 9-15.
11. Helmeste D. M. and Tang S. W. (1995) Tyrosine kinase inhibitors regulate serotonin uptake in platelets. Eur. J. Pharmacol. 280, R5-R7.
12. Jayanthi L. D., Ramamoorthy S., Mahesh V. B., Leibach F. H., and Ganapathy V. (1994) Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J. Biol. Chem. 269, 14424-14429.
13. Kamei Y., Tsutsumi O., Kuwabara Y., and Taketani Y. (1993) Intrauterine growth retardation and fetal losses are caused by epidermal growth factor deficiency in mice. Am. J. Physiol. 264, R597-R600.
14. Launay J. M., Bondoux D., Oset-Gasque M. J., Emami S., Mutel V., Haimart M., and Gespach C. (1994) Increase of human platelet serotonin uptake by atypical histamine receptors. Am. J. Physiol. 266, R526-R536.
15. Meltzer H. Y. and Lowy M. T. (1987) The serotonin hypothesis of depression, in Psychopharmacology: The Third Generation of Progress (Meltzer H. Y., ed), pp. 513-526. Raven Press, New York.
16. 3 receptors regulate serotonin transport via nitric oxide and cGMP. J. Biol. Chem. 269, 27351-27356.
17. Myers C. L., Lazo J. S., and Pitt B. R. (1989) Translocation of protein kinase C is associated with inhibition of 5-HT uptake by cultured endothelial cells. Am. J. Physiol. 257, L253-L258.
18. Nishio H., Nezasa K., and Nakata Y. (1995) Role of calcium ion in platelet serotonin uptake regulation. Eur. J. Pharmacol. 288, 149-155.
19. Okada N. and Koizumi S. (1995) A neuroprotective compound, aurintricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells. J. Biol. Chem. 270, 16464-16469.
20. Owens M. J. and Nemeroff C. B. (1994) Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40, 288-295.
21. Prasad P. D., Hoffman B. J., Moe A. J., Smith C. H., Leibach F. H., and Ganapathy V. (1996) Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells. Placenta 17, 201-207.
22. Ramamoorthy S., Cool D. R., Mahesh V. B., Leibach F. H., Melikian H. E., Blakely R. D., and Ganapathy V. (1993a) Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. J. Biol. Chem. 268, 21626-21631.
23. Ramamoorthy S., Bauman A. L., Moore K. R., Han H., Yang-Feng T. L., Chang A. S., Ganapathy V., and Blakely R. D. (1993b) Antidepressant- and cocaine-sensitive human serotonin transporter. Molecular cloning, expression, and chromosomal localization. Proc. Natl. Acad. Sci. USA 90, 2542-2546.
24. Ramamoorthy J. D., Ramamoorthy S., Papapetropoulos A., Catravas J. D., Leibach F. H., and Ganapathy V. (1995a) Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells. J. Biol. Chem. 270, 17189-17195.
25. Ramamoorthy S., Ramamoorthy J. D., Prasad P. D., Bhat G. K., Mahesh V. B., Leibach F. H., and Ganapathy V. (1995b) Regulation of the human serotonin transporter by interleukin-1β. Biochem. Biophys. Res. Commun. 216, 560-567.
26. Roberts-Lewis J. M., Marcy V. R., Zhao Y., Vaught J. L., Siman R., and Lewis M. E. (1993) Aurintricarboxylic acid protects hippocampal neurons from NMDA- and ischemia-induced toxicity in vivo. J. Neurochem. 61, 378-381.
27. van Praag H. M. (1984) Depression, suicide, and serotonin metabolism in the brain, in Neurobiology of Mood Disorders, Vol. I (Post R. M. and Ballenger J. C., eds), pp. 601-618. Williams and Wilkins, Baltimore.