Gene signature in Alzheimer's disease and environmental factors: The virus chronicle

Journal of Alzheimer's Disease

Volumn 27, Issue 4, 2011, Pages 809-817

  Licastro, Federico ^a   Carbone, Ilaria ^a   Ianni, Manuela ^a   Porcellini, Elisa ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Alzheimer's disease; genetic background; GWA studies; herpes virus

Indexed keywords

APOLIPOPROTEIN E; CD2 ASSOCIATED PROTEIN; CELL ADHESION MOLECULE; CLATHRIN ASSEMBLY PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C3B RECEPTOR; EPHRIN RECEPTOR A1; LECTIN; NECTIN 2; PHOSPHATIDYLINOSITOL; PROTEIN BCL 3;

AGING; ALZHEIMER DISEASE; ARTICLE; B CELL LYMPHOMA; CENTRAL NERVOUS SYSTEM; ENVIRONMENTAL FACTOR; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; HERPES VIRUS INFECTION; HUMAN; INFECTION SENSITIVITY; INFLAMMATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS LATENCY;

EID: 84455162524     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110755     Document Type: Article

References (78)

1. Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL (2006) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63, 168-174 (Pubitemid 43213878)
2. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimers Disease Initiative Investigators, de Pancorbo MM,Lendon C, Dufouil C, Jaillard C, LeveillardT, AlvarezV, Bosco P, Mancuso M, Panza F, Nacmias B, Bossú P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identities variants atCLUandCR1associated with Alzheimers disease. Nat Genet 41, 1094-1099
3. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K,Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J,Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van BroeckhovenC,Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N,Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, ODonovan M, Owen MJ, Williams J (2009) Genome-wide association study identities variants at CLU and PICALM associated with Alzheimers disease. Nat Genet 41, 1088-1093
4. Porcellini E, Carbone I, Ianni M, Licastro F (2010) Alzheimers disease gene signature says: Beware of brain viral infections. Immun Ageing 14, 7-16
5. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D,Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H,Warden D,Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, MaierW, Jessen F, Rüther E, Schürmann B, Heun R,Kölsch H, van den Bussche H, Heuser I,Kornhuber J,Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, Alzheimers Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, CHARGE consortium, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M, EADI1 consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossú P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, ODonovan M, Amouyel P, Williams J (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimers disease. Nat Genet 43, 429-435
6. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA,Williamson J,Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak- Vance MA, Farrer LA, Schellenberg GD (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimers disease. Nat Genet 43, 436-441
7. Kim WS, Guillemin GJ, Glaros EN, Lim CK, GarnerB(2006) Quantitation ofATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport 17, 891-896 (Pubitemid 43869954)
8. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW,Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR (2006) ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol 174, 547-556
9. Ikeda Y, Abe-Dohmae S, Munehira Y, Aoki R, Kawamoto S, Furuya A, Shitara K, Amachi T, Kioka N, Matsuo M, Yokoyama S, Ueda K (2003) Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem Biophys Res Commun 14, 313-318 (Pubitemid 37340078)
10. Hayashi M, Abe-Dohmae S, Okazaki M, Ueda K, Yokoyama S (2005) Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. J Lipid Res 48, 1703-1711 (Pubitemid 41099337)
11. André P, Perlemuter G, Budkowska A, Bréchot C, Lotteau V (2005) HepatitisCvirus particles and lipoprotein metabolism. Semin Liver Dis 25, 93-104
12. Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW (2005) Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem 4, 3989-3995 (Pubitemid 40223868)
13. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW,Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR (2006) ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol 174, 547-556
14. Kinet JP, Blank U, Ra C, White K, Metzger H, Kochan J (1988) Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A 85, 6483-6487
15. Crocker PR, Paulson JC, Varki A (2007) Siglecs and their roles in the immune system. Nat Rev Immunol 7, 255-266 (Pubitemid 46480955)
16. Liang Y, Buckley TR, Tu L, Langdon SD, Tedder TF (2001) Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics 53, 357-368 (Pubitemid 32762813)
17. Gill MA, BajwaG, George TA, Dong CC, Dougherty II, Jiang N, Gan VN, Gruchalla RS (2010) Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol 184, 5999-6006
18. Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, AlevyY,Yan L,Agapov E, Kim EY, Holtzman MJ (2007) Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204, 2759-2769 (Pubitemid 350044797)
19. Dugas N, Lacroix C, Kilchherr E, Delfraissy JF, Tardieu M (2001) Role of CD23 in astrocytes inflammatory reaction during HIV-1 related encephalitis. Cytokine 15, 96-107 (Pubitemid 34920510)
20. Marone G, Florio G, Petraroli A, de Paulis A (2001) Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. J Allelrgy Clin Immunol 107, 22-30 (Pubitemid 32105239)
21. Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ (2003) A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem 278, 21805-21813 (Pubitemid 36792585)
22. Ma Y, Yang H, Qi J, Liu D, Xiong P, Xu Y, Feng W, Zheng G, Li P, Fang M, Tan Z, Zheng F, Gong F (2010) CD2AP is indispensable to multistep cytotoxic process byNKcells. Mol Immunol 47, 1074-1082
23. Schiffer M, Mundel P, Shaw AS, Böttinger EP (2004) A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem 279, 37004-37012 (Pubitemid 39129050)
24. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (2003) CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic 4, 97-112 (Pubitemid 36621703)
25. Tateno H, Li H, Schur MJ, Bovin N, Crocker PR,Wakarchuk WW, Paulson JC (2007) Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol 27, 5699-5710 (Pubitemid 47257827)
26. Stern JL, Slobedman BJ (2008) Human cytomegalovirus latent infection of myeloid cells directs monocyte migration by up-regulating monocyte chemotactic protein-1. J Immunol 180, 6577-6585
27. Hahn G, Jores R, Mocarski ES (1998) Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells. Proc Natl Acad Sci U S A 95, 3937-3942 (Pubitemid 28173232)
28. Mirandola P, Secchiero P, Pierpaoli S, Visani G, Zamai L, Vitale M, Capitani S, Zauli G (2000) Infection of CD34(+) hematopoietic progenitor cells by human herpesvirus 7(HHV- 7). Blood 96, 126-131 (Pubitemid 30456460)
29. Wu JQ, Dyer WB, Chrisp J, Belov L, Wang B, Saksena NK (2008) Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy. Retrovirology 4, 5-24
30. Dolganiuc A, Norkina O,Kodys K, Catalano D, Bakis G, Marshall C, Mandrekar P, Szabo G (2007) Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 133, 1627-1636 (Pubitemid 350029734)
31. Coulthard MG, Lickliter JD, Subanesan N, Chen K, Webb GC, Lowry AJ, Koblar S, Bottema CD, Boyd AW (2001) Characterization of the Epha1 receptor tyrosine kinase: Expression in epithelial tissues. Growth Factors 18, 303-317 (Pubitemid 32776309)
32. Yamazaki T, Masuda J, Omori T, Usui R, Akiyama H, Maru Y (2009) EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. J Cell Sci 122, 243-255
33. Duffy SL, Coulthard MG, Spanevello MD, Herath NI,Yeadon TM, McCarron JK, Carter JC, Tonks ID, Kay GF, Phillips GE, Boyd AW (2008) Generation and characterization of EphA1 receptor tyrosine kinase reporter knockout mice. Genesis 46, 553-561
34. Ivanov AI, Romanovsky AA (2006) Putative dual role of ephrin-Eph receptor interactions in inflammation. IUBMB Life 58, 389-394
35. Itzhaki RF,Wozniak MA (2008) Herpes simplex virus type 1 in Alzheimers disease: The enemy within. J Alzheimers Dis 13, 393-405 (Pubitemid 352039023)
36. Carter CJ (2008) Interactions between the products of the Herpes simplex genome and Alzheimers disease susceptibility genes: Relevance to pathological-signalling cascades. Neurochem Int 52, 920-934
37. Wozniak MA, Mee AP, Itzhaki RF (2009) Herpes simplex virus type 1 DNA is located within Alzheimers disease amyloid plaques. J Pathol 217, 131-138
38. Burgos JS, Ramirez C, Sastre I, Valdivieso F (2007) Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner. Aging Cell 6, 841-842 (Pubitemid 350131052)
39. Burgos JS, Ramirez C, Sastre I, Valdivieso F (2006) Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA. J Virol 80, 5383-5387
40. Burgos JS, Ramirez C, Sastre I, Bullido MJ, Valdivieso F (2003) ApoE4 is more efficient than E3 in brain access by herpes simplex virus 1. Neuroreport 14, 1825-1827 (Pubitemid 37372611)
41. Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA (1997) Herpes simplex virus type 1 in brain and risk of Alzheimers disease. Lancet 349, 241-244 (Pubitemid 27050990)
42. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB (2007) Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci Lett 429, 95-100 (Pubitemid 350161114)
43. Wozniak MA, Itzhaki RF (2010) Antiviral agents in Alzheimers disease: Hope for the future? Ther Adv Neurol Disord 3, 141-152
44. Mori I, KimuraY, Naiki H, Matsubara R, Takeuchi T,Yokochi T, Nishiyama Y (2004) Reactivation of HSV-1 in the brain of patients with familial Alzheimers disease. J Med Virol 73, 605-611 (Pubitemid 38857213)
45. Cheon MS, Bajo M, Gulesserian T, Cairns N, Lubec G (2001) Evidence for the relation of herpes simplex virus type 1 to Downsyndrome and Alzheimers disease. Electrophoresis 22, 445-448 (Pubitemid 32166565)
46. Annerén G, Gronowitz JS, Källander CF, Sundqvist VA (1986) Mothers of children with Down syndrome have higher herpes simplex virus type 2 (HSV-2) antibody levels. Hum Genet 72, 9-14 (Pubitemid 16186468)
47. Santana S, Recuero M, Bullido MJ, Valdivieso F, Aldudo J (2011) Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells. Neurobiol Aging, doi:10.1016/j.neurobiolaging.2010. 12.010
48. Piacentini R, Civitelli L, Ripoli C, Marcocci ME, De Chiara G, Garaci E, Azzena GB, Palamara AT, Grassi C (2010) HSV-1 promotes Ca(2+)-mediated APP phosphorylation and A accumulation in rat cortical neurons. Neurobiol Aging, doi:10.1016/j.neurobiolaging.2010.06.009
49. Carter CJ (2011) Alzheimers disease plaques and tangles: Cemeteries of a Pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction. Neurochem Int 58, 301-320
50. Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM (2000) Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimers A beta peptide. Biochemistry 39, 5988-5994 (Pubitemid 30327072)
51. De Chiara G, Marcocci ME, Civitelli L, Argnani R, Piacentini R, Ripoli C, Manservigi R, Grassi C, Garaci E, Palamara AT (2010) APP processing induced by herpes simplex virus type (HSV-1) yields several APP fragments in human and rat neuronal cells. PlosOne 5, e13989
52. Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE,WalkerLC(2000) Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. J Neurosci 20, 3606-3611 (Pubitemid 30266223)
53. Doty RL (2008) The olfactory vector hypothesis of neurodegenerative disease: Is it viable? Ann Neurol 63, 7-15 (Pubitemid 351240546)
54. McLean JH, Shipley MT, Bernstein DI, Corbett D (1993) Selective lesions of neural pathways following viral inoculation of the olfactory bulb. Exp Neurol 122, 209-222 (Pubitemid 23290403)
55. Doty RL (2003) In Hand Book of Olfaction and Gustation 2nd ed, Marcel Dekker, New York, 479-502
56. Ohm TG, Braak H (1987) Olfactory bulb changes in Alzheimers disease. Acta Neuropathol 73, 365-369 (Pubitemid 17113539)
57. Porcellini E, Davis EJ, Chiappelli M, Ianni E, Di Stefano G, Forti P, Ravaglia G, Licastro F (2008) Elevated plasma levels of alpha-1-anti- chymotrypsin in age-related cognitive decline and Alzheimers disease: A potential therapeutic target. Curr Pharm Des 14, 2659-2664
58. Licastro F, Chiappelli M, Grimaldi LM, MorganK, Kalsheker N, Calabrese E, Ritchie A, Porcellini E, Salani G, Franceschi M, Canal N (2005) A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimers disease. Neurobiol Aging 26, 449-453 (Pubitemid 40093928)
59. Licastro F, Masliah E, Pedrini S, Thal LJ (2000) Blood levels of alpha-1-antichymotrypsin and risk factors for Alzheimers disease: Effects of gender and apolipoprotein E genotype. Dement Geriatr Cogn Disord 11, 25-28 (Pubitemid 30025940)
60. DeKosky ST, Ikonomovic MD, Wang X, Farlow M, Wisniewski S, Lopez OL, Becker JT, Saxton J, Klunk WE, Sweet R, Kaufer DI, Kamboh MI (2003) Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimers disease: Correlation with cognitive impairment. Ann Neurol 53, 81-90 (Pubitemid 36083832)
61. Dik MG, Jonker C, Hack CE, Smit JH, Comijs HC, Eikelenboom P (2005) Serum inflammatory proteins and cognitive decline in older persons. Neurology 64, 1371-1377 (Pubitemid 40570504)
62. Friis H, Gomo E, Nyazema N, Ndhlovu P, Krarup H, Madsen PH, Michaelsen KF (2003) Iron, haptoglobin phenotype, and HIV-1 viral load: A cross-sectional study among pregnant Zimbabwean women. Jacquir Immun Defic Syndr 1, 74-81 (Pubitemid 36547244)
63. Thomas RM, Schiano TD, Kueppers F, Black M (2000) Alpha1-antichymotrypsin globules within hepatocytes in patients with chronic hepatitis C and cirrhosis. Hum Pathol 31, 575-577 (Pubitemid 30323982)
64. Licastro F, Porcellini E, Caruso C, Lio D, Corder EH (2007) Genetic risk profiles for Alzheimers disease: Integration of APOE genotype and variants that up-regulate inflammation. Neurobiol Aging 28, 1637-1643 (Pubitemid 47384944)
65. Chiappelli M, Borroni B, Archetti S, Calabrese E, Corsi MM, Franceschi M, Padovani A, Licastro F (2006) VEGF gene and phenotype relation with Alzheimers disease and mild cognitive impairment. Renjuven Res 9, 485-493 (Pubitemid 46100670)
66. Brogan IJ, Khan N, Isaac K, Hutchinson JA, Pravica V, Hutchinson IV (1999) Novel polymorphisms in the promoter and 5 UTR regions of the human vascular endothelial growth factor gene. Hum Immunol 60, 1245-1249 (Pubitemid 30017507)
67. Del Bo R, Scarlato M, Ghezzi S, Martinelli Boneschi F, Fenoglio C, Galbiati S, Virgilio R, Galimberti D, Galimberti G, Crimi M, Ferrarese C, Scarpini E, Bresolin N, Comi GP (2005) Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann Neurol 57, 373-380 (Pubitemid 40343959)
68. Zlokovic BV (2005) Neurovascular mechanisms of Alzheimers neurodegeneration. Trends Neurosci 28, 202-208
69. de la Torre JC (2004) Is Alzheimers disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 3, 184-190 (Pubitemid 38232669)
70. Caruso A, Caselli E, Fiorentini S, Rotola A, Prandini A, Garrafa E, Saba E, Alessandri G, Cassai E, Di Luca D (2009) U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis. Proc Natl Acad Sci U S A 106, 20446-20451
71. Cao L, Jiao X, Zuzga DS, Liu Y, Fong DM, Young D, During MJ (2004) VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet 36, 827-835 (Pubitemid 39014099)
72. Licastro F, Chiappelli M, Caldarera CM, Porcellini E, Carbone I, Caruso C, Lio D, Corder EH (2011) Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimers disease as shown by partially overlapping of gene variant profiles. J Alzheimers Dis 23, 1-11
73. Vescovini R, Biasini C, Telera AR, Basaglia M, Stella A, Magalini F, Bucci L, Monti D, Lazzarotto T, Dal Monte P, Pedrazzoni M, Medici MC, Chezzi C, Franceschi C, Fagnoni FF, Sansoni P (2010) Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol 184, 3242-3249
74. Stowe RP, Kozlova EV, Yetman DL, Walling DM, Goodwin JS, Glaser R (2007) Chronic herpesvirus reactivation occurs in aging. Exp Gerontol 42, 563-570 (Pubitemid 46756093)
75. Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ (2009) Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci U S A 106, 14063-14068
76. Aiello AE, Haan M, Blythe L, Moore K, Gonzalez JM, Jagust W (2006) The influence of latent viral infection on rate of cognitive decline over 4 years. J Am Geriatr Soc 54, 1046-1054 (Pubitemid 43992540)
77. Hemling N, Röyttä M, Rinne J, Pöllänen P, Broberg E, Tapio V, Vahlberg T, Hukkanen V (2003) Herpesviruses in brains in Alzheimers and Parkinsons diseases. Ann Neurol 54, 267-271 (Pubitemid 36909630)
78. Candore G, Balistreri CR, Colonna-Romano G, Lio D, Caruso C (2004) Major histocompatibility complex and sporadic Alzheimers disease: A critical reappraisal. Exp Gerontol 39, 645-652 (Pubitemid 38402092)