Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profiles

Journal of Alzheimer's Disease

Volumn 23, Issue 3, 2011, Pages 421-431

  Licastro, Federico ^a   Chiappelli, Martina ^a   Caldarera, Claudio Marcello ^b   Porcellini, Elisa ^a   Carbone, Ilaria ^a   Caruso, Calogero ^c   Lio, Domenico ^c   Corder, Elizabeth H ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Istituto Nazionale Per le Ricerche Cardiovascolari (INRC)   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d Matrix Genomics Inc   (United States)

Author keywords

Acute myocardial infarction; Alzheimer's disease; APOE; cholesterol; gene polymorphism; genetic epidemiology; grade of membership analysis; inflammation

Indexed keywords

APOLIPOPROTEIN E4; CHOLESTEROL; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ACUTE HEART INFARCTION; ADULT; AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; ARTICLE; CHOLESTEROL METABOLISM; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; FUZZY SYSTEM; GENE FREQUENCY; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; INFLAMMATION; ITALY; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 79951923970     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-090871     Document Type: Article

References (84)

1. Nussbaum MD, Christopher E Ellis (2003) Alzheimer's Disease and Parkinson's Disease. N Engl J Med 348,1356-1364. (Pubitemid 36384104)
2. Katzman RN (1996) Medical progress: Alzheimer's disease. N Engl J Med 274, 964-973.
3. Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 17, 761-766. (Pubitemid 26348877)
4. Tarkowski E, Andreasen N, Tarkowski A, Blennow K (2003) Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry 74, 1200-1205.
5. Licastro F, Mallory M, Hansen LA, Masliah E (1998) Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype. J Neuroimmunol 88,105-110. (Pubitemid 28342910)
6. Munch G, Apelt J, Rosemarie-Kientsch-Engel, Stahl P, Luth HJ, Schliebs R (2003) Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology. J Neurochem 86, 283-289. (Pubitemid 36842428)
7. Licastro F, Chiappelli M (2003) Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background. Mech Ageing Dev 124, 539-548. (Pubitemid 36514911)
8. Shepherd CE, Gregory GC, Vickers JC, Halliday GM (2005)Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease. Neuropathol Appl Neurobiol 31, 503-511. (Pubitemid 41337784)
9. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ (2002) Early inflammation and dementia: a 25-year followup of the Honolulu-Asia Aging Study. Ann Neurol 52,168-174. (Pubitemid 34810596)
10. Licastro F, Davis LJ, Morini MC, Cucinotta D, Savorani G (1994) Cerebrospinal fluid of patients with senile dementia of Alzheimer's type shows an increased inhibition of alphachymotrypsin. Alzheimer Dis Assoc Disord 8, 241-249.
11. Licastro F, Chiappelli M, Grimaldi LM, Morgan K, Kalsheker N, Calabrese E, Ritchie A, Porcellini E, Salani G, Franceschi M, Canal N (2005) A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease. Neurobiol Aging 26, 449-453. (Pubitemid 40093928)
12. Porcellini E, Davis EJ, Chiappelli M, Ianni E, Di Stefano G, Forti P, Ravaglia G, Licastro F (2008) Elevated plasma levels of alpha-1-anti- chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target. Curr Pharm Des 14, 2659-2664.
13. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, SmallGW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923. (Pubitemid 23275809)
14. Grimaldi LM, Casadei VM, Ferri C, Veglia F, Licastro F, Annoni G, Biunno I, De Bellis G, Sorbi S, Mariani C, Canal N, Griffin WS, Franceschi M (2000) Association of earlyonset Alzheimer's disease with an interleukin-1alpha gene polymorphism. Ann Neurol 47, 361-365. (Pubitemid 30141846)
15. Licastro F, Pedrini S, Ferri C, Casadei V, Govoni M, Pession A, Sciacca FL, Veglia F, Annoni G, Bonafe M, Olivieri F, Franceschi C, Grimaldi LM (2000) Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann Neurol 48, 388-391.
16. Licastro F, Grimaldi LM, Bonafe M, Martina C, Olivieri F, Cavallone L, Giovanietti S, Masliah E, Franceschi C (2003) Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 24, 921-926. (Pubitemid 36962977)
17. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C (2005) Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 18, 2-8.
18. Lio D, Licastro F, Scola L, Chiappelli M, Grimaldi LM, Crivello A, Colonna-Romano G, Candore G, Franceschi C, Caruso C (2003) Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immun 4, 234-238. (Pubitemid 38967602)
19. Braunwald E (1997) Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 337, 1360-1369. (Pubitemid 27467771)
20. Weir RA, McMurray JJ, Velazquez EJ (2006) Epidemiology of heart failure and left ventricular systolic dysfunction after acute myocardial infarction: prevalence, clinical characteristics, and prognostic importance. Am J Cardiol 97, 13F-25F.
21. Gupta R, Kaufman S (2006) Cardiovascular emergencies in the elderly. Emerg Med Clin North Am 24, 339-370.
22. Rifai N, Ridker PM (2001) High-sensitivity C-reactive protein: a novel and promising marker of coronary heart disease. Clin Chem 47, 403-411. (Pubitemid 32222452)
23. Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braunwald E (2000) Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101, 2149-2153. (Pubitemid 30253042)
24. Jenny NS, Tracy RP, Ogg MS, Luong le A, Kuller LH, Arnold AM, Sharrett AR, Humphries SE (2002) In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol 22, 2066-2071. (Pubitemid 36025216)
25. Utermann G, Hardewig A, Zimmer F (1984) Apolipoprotein E phenotypes in patients with myocardial infarction. Hum Genet 65, 237-241. (Pubitemid 14182014)
26. Lenzen HJ, Assmann G, Buchwalsky R, Schulte H (1986) Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. Clin Chem 32, 778-781. (Pubitemid 17028348)
27. Eichner JE, Kuller LH, Orchard TJ, Grandits GA, McCallum LM, Ferrell RE, Neaton JD (1993) Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am J Cardiol 71, 160-165. (Pubitemid 23030638)
28. Lehtinen S, Lehtimaki T, Sisto T, Salenius JP, Nikkila M, Jokela H, Koivula T, Ebeling F, Ehnholm C (1995) Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men andwomen. Atherosclerosis 114, 83-91.
29. Scaglione L, Bergerone S, Gambino R, Imazio M, Macchia G, Cravetto A, Gaschino G, Baralis G, Rosettani E, Pagano G, Cassader M (1999) Role of lipid, apolipoprotein levels and apolipoprotein E genotype in young Italian patients with myocardial infarction. Nutr Metab Cardiovasc Dis 9, 118-124. (Pubitemid 129632897)
30. Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, Hoffmann E, Caruso M, Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C (2004) Opposite effects of interleukin common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet 41, 790-794. (Pubitemid 39389298)
31. Licastro F, Chiappelli M, Caldarera CM, Tampieri C, Nanni S, Gallina M, Branzi A (2002) The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study. Mech Ageing Dev 125, 575-579. (Pubitemid 39150001)
32. Ray KK, Camp NJ, Bennett CE, Francis SE, Crossman D (2002) Genetic variation at the interleukin-1 locus is a determinant of changes in soluble endothelial factors in patients with acute coronary syndromes. Clin Sci (Lond) 103, 303-310. (Pubitemid 35007222)
33. Chiappelli M, Tampieri C, Tumini E, Porcellini E, Caldarera CM, Nanni S, Branzi A, Lio D, Caruso M, Hoffmann E, Caruso C, Licastro F (2005) Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet 32, 349-353. (Pubitemid 41735572)
34. Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ (2001) The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22, 2243-2252. (Pubitemid 34000979)
35. Andreotti F, Porto I, Crea F, Maseri A (2002) Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies. Heart 87, 107-112. (Pubitemid 34098367)
36. Giacconi R, Cipriano C, Albanese F, Boccoli G, Saba V, Olivieri F, Franceschi C, MoccheggianiE(2004) The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. Exp Gerontol 39, 621-628. (Pubitemid 38402089)
37. Licastro F, Porcellini E, Caruso C, Lio C, Corder EH (2007) Genetic risk profiles for Alzheimer's disease: Integration of APOE genotype and gene variants that up-regulate inflammation. Neurobiol Aging 28, 1637-1643. (Pubitemid 47384944)
38. Stampfer MJ (2006) Cardiovascular disease and Alzheimer's disease: common links. Review. J Intern Med 260, 211-223. (Pubitemid 44253634)
39. Casserly I, Topol E (2004) Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 363, 1139-1146. (Pubitemid 38452789)
40. Honig LS, Kukull W, Mayeux R (2005) Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center. Neurology 64, 494-500. (Pubitemid 40189869)
41. Beeri MS, Rapp M, Silverman JM, Schmeidler J, Grossman HT, Fallon JT, Purohit DP, Perl DP, Siddiqui A, Lesser G, Rosendorff C, Haroutunian V (2006) Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. Neurology 66, 1399-1404. (Pubitemid 43739650)
42. Beach TG,Wilson JR, Sue LI, Newell A, Poston M, Cisneros R, Pandya Y, Esh C, Connor DJ, Sabbagh M, Walker DG, Roher AE (2007) Circle ofWillis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles. Acta Neuropathol (Berl) 113, 13-21. (Pubitemid 44782925)
43. Kalback W, Esh C, Castano EM, Rahman A, Kokjohn T, Luehrs DC, Sue L, Cisneros R, Gerber F, Richardson C, Bohrmann B, Walker DG, Beach TG, Roher AE (2004) Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease. Neurol Res 26, 525-539. (Pubitemid 38879235)
44. Roher AE, Garami Z, Alexandrov AV, Kokjohn TA, Esh CL, Kalback WM, Vedders LJ, Wilson JR, Sabbagh MN, Beach TG (2006) Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease. Neurol Res 28, 672-678. (Pubitemid 44433328)
45. Newman AB, Fitzpatrick AL, Lopez O, Jackson S, Lyketsos C, JagustW, Ives D, Dekosky ST,Kuller LH (2005) Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. J Am Geriatr Soc 53, 1101-1107. (Pubitemid 41632508)
46. Panza F, D'Introno A, Colacicco AM, Capurso C, Parigi AD, Capurso SA, Caselli RJ, Pilptto A, Scafato E, Capurso A, Solfrizzi V (2006) Cognitive fraility: predementia syndrome and vascular risk factors. Neurobiol Aging 27, 933-940. (Pubitemid 43732521)
47. de la Torre JC (2006) Howdo heart disease and stroke become risk factors for Alzheimer's disease? Neurol Res 28, 637-644. (Pubitemid 44433323)
48. Corder EH, Ervin JF, Falls E, Lockhart E, Szymanski MH, Schmechel DE, HuletteCM(2005) Cardiovascular damage in Alzheimer Disease: Autopsy findings from the Bryan ADRC. J Biomed Biotechnol 2005, 189-197. (Pubitemid 41627876)
49. García Rodríguez LA, Varas-Lorenzo C, Maguire A, González-Pérez A (2004) Nonsteroidal Antiinflammatory Drugs and the Risk of Myocardial Infarction in the General Population. Circulation 109, 3000-3006. (Pubitemid 38808323)
50. Gracia Rodriguez LA, Gonzales-Perez A (2005) Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population. BMC Med 29, 3:17.
51. in t'Veld BA, RuitenbergA, Hofman A, Launer LJ, van Duijn CM,StijnenT, BretelerMM,StrickerBH(2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345, 1515-1521. (Pubitemid 33144916)
52. Briel M, Nordmann AJ, Bucher HC (2005) Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses. Curr Opin Lipidol 16, 601-605. (Pubitemid 43012155)
53. Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ (2007) Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 69, 878-885. (Pubitemid 47329587)
54. Menge T, Hartung HP, Stuve O (2005) Statins a cure all for the brain? Nat Rev Neurosci 6, 325-331.
55. Jain MK, Ridker PM (2005) Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov 4, 977-987.
56. Woodbury MA, Clive J (1974) Clinical pure types as a fuzzy partition. J Cybernetics 4, 111-121.
57. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944. (Pubitemid 14076461)
58. Woodbury MA, Clive J, Garson A (1978) Mathematical Typology: A Grade of Membership Technique for Obtaining Disease Definition. Comput Biomed Res 11, 277-298. (Pubitemid 8404324)
59. Woodbury MA, Manton KG, Tolley DH (1994) A general model for statistical analysis using fuzzy sets: sufficient conditions for identifiability and statistical properties. Information Sciences 1, 149-180. (Pubitemid 24402994)
60. Manton KG, Woodbury MA, Wrigley JM, Cohen HJ (1991) Multivariate procedures to describe clinical staging of melanoma. Methods Inf Med 30, 111-116.
61. Corder EH, Woodbury MA (1993) Genetic heterogeneity in Alzheimer's disease: A grade of membership analysis. Genet Epidemiol 10, 495-499. (Pubitemid 24020322)
62. Manton KG, Corder L, Stallard E (1997) Chronic disability trends in elderly United States populations: 1982-1994. Proc Natl Acad Sci U S A 94, 2593-2598.
63. Manton KG, Korten A, Woodbury MA, Anker M, Jablensky A (1994) Symptom profiles of psychiatric disorders based on graded disease classes: an illustration using data from the WHO International Pilot Study of Schizophrenia. Psychol Med 24, 133-144. (Pubitemid 24083689)
64. Hallmayer JF, Kalaydjieva L, Badcock J, Dragovic M, Howell S, Michie PT, Rock D, Vile D, Williams R, Corder EH, Hollingsworth K, Jablensky (2005) Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit. Am J Hum Genet 77, 468-476. (Pubitemid 41192652)
65. Corder EH, Woodbury MA, Volkmann I, Madsen DK, Bogdanovic N, Winblad B (2000) Density profiles of Alzheimer disease regional brain pathology for the Huddinge Brain Bank: pattern recognition emulates and expands upon Braak staging. Exp Gerontol 35, 851-864.
66. Corder EH, Woodbury MA, Field LL (2001) Grade-of- Membership sibpair linkage analysis maps the IDDM11 locus to chromosome 14q24.3-q31: A pattern recognition approach to linkage. Ann Hum Genet 65, 387-394. (Pubitemid 32936695)
67. Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A,Vepsäläinen S, HänninenT, Soininen H, HiltunenM(2004) Polymorphisms in the CYP19 gene confer increased risk for Alzheimer's disease. Neurology 62, 1170-1176. (Pubitemid 38456512)
68. Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder E, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H (2004) Genetic variation in apolipoproteinDand Alzheimer's disease. J Neurol 251, 951-957. (Pubitemid 39119313)
69. Corder EH, Huang R, Cathcart HM, Lanham IS, Parker GR, Cheng D, Smith S, Poduslo SE (2006) Membership in genetic groups predicts Alzheimer's Disease. Rejuvenation Res 9, 89-93.
70. Corder EH, Beaumont H (2007) Susceptibility groups for Alzheimer's disease (OPTIMA cohort): Integration of gene variants and biochemical factors. Mech Ageing Dev 128, 76-82. (Pubitemid 46073063)
71. Golanska E, Hulas-Bigoszewska K, Sieruta M, Zawlik I, Witusik M, Gresner SM, Sobow T, Styczynska M, Peplonska B, Barcikowska M, Liberski PP, Corder EH (2009) Earlier Onset of Alzheimer's Disease: Risk Polymorphisms Within PRNP, PRND, CYP46, and APOE Genes. J Alzheimers Dis 17, 359-368.
72. Corder EH, Lannfelt L, Viitanen M, Corder LS, Winblad B (2005) 'Does apolipoprotein E polymorphism determine the survivability of vascular accidents at advanced ages? Implications for mortality differentials', eds. Longer Life and Healthy Aging, Boston, Mass: Kluwer Academic Publishers, pp. 141- 150.
73. Corder EH, Hefler LA (2006) Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma. Rejuvenation Res 9, 56-60.
74. Corder EH, Mellick GD (2006) Parkinson's disease in relation to pesticide exposure and nuclear encoded mitochondrial complex I gene variants. J Biomed Biotechnol 2006, 27601.
75. Paisán-Ruiz C,Washecka N, Nath P, Singleton AB, CorderEH (2009) Parkinson's disease and low frequency alleles found together throughout LRRK2. Ann Hum Genet 73, 391-403.
76. Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82, 636-643.
77. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM,Lendon C, Dufouil C, Jaillard C, LeveillardT, AlvarezV, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identifies variants atCLUandCR1associated with Alzheimer's disease. Nat Genet 41, 1094-1099.
78. Licastro F, Chiapelli M, Caldarera CM, Caruso C, Lio D, Corder EH (2007) Acute myocardial infarction and proinflammatory gene variants. Ann N Y Acad Sci 1119, 227-242. (Pubitemid 350191222)
79. Tousoulis D, Antoniades C, Koumallos N, Stefanadis C (2006) Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside. Cytokine Growth Factor Rev 17, 225-233. (Pubitemid 44038615)
80. Koenig W, Rosenson RS (2002) Acute-phase reactants and coronary heart disease. Semin Vasc Med 2, 417-428.
81. Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int Rev Neurobiol 82, 235-246.
82. Finch CE, Morgan TE (2007) Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res 4, 185-189. (Pubitemid 46562393)
83. Chiappelli M, Tumini E, Porcellini E, Licastro F (2006) Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies. Expert Rev Neurother 6, 1327-1336. (Pubitemid 44580955)
84. Rosendorff C, Beeri MS, Silverman JM (2007) Cardiovascular risk factors for Alzheimer's disease. Am J Geriatr Cardiol 16, 143-149.