Physicochemical studies on the stability of influenza haemagglutinin in vaccine bulk material

European Journal of Pharmaceutical Sciences

Volumn 23, Issue 1, 2004, Pages 65-75

  Luykx, Dion M A M ^a   Casteleijn, Marco G ^a   Jiskoot, Wim ^b   Westdijk, Janny ^c   Jongen, Peter M J M ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS VACCINE INSTITUTE   (Netherlands)

Author keywords

Circular dichroism spectroscopy; Fluorescence spectroscopy; Influenza virus haemagglutinin; Physicochemical characterisation; Stability

Indexed keywords

INFLUENZA VACCINE; TRYPTOPHAN; VIRUS HEMAGGLUTININ;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG STABILITY; FLUORESCENCE SPECTROSCOPY; FREEZING; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NONHUMAN; OXIDATION; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRAIN DIFFERENCE; STRUCTURE ANALYSIS; THAWING; THERMOSTABILITY; VIRUS STRAIN;

CHEMISTRY, PHYSICAL; CIRCULAR DICHROISM; DRUG STABILITY; FREEZING; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNODIFFUSION; INDICATORS AND REAGENTS; INFLUENZA VACCINES; PROTEIN CONFORMATION; PROTEIN DENATURATION; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE;

EID: 8444250949     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.05.007     Document Type: Article

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