Pharmacological profile of CR3465, a new leukotriene CysLT 1 receptor antagonist with broad anti-inflammatory activity

European Journal of Pharmacology

Volumn 504, Issue 3, 2004, Pages 223-233

  Ferrari, Flora ^a   Mennuni, Laura ^a   Caselli, Gianfranco ^a   Zanelli, Tiziano ^a   Makovec, Francesco ^a  

^a Via Valosa Sopra 7/9 20052 M   (Italy)

Author keywords

Airway inflammation; Asthma; Cysteinyl leukotriene; Leukotriene CysLT 1 receptor; Leukotriene receptor antagonist

Indexed keywords

ANTIINFLAMMATORY AGENT; CR 3465; DEXAMETHASONE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HISTAMINE; ISOBUTYLMETHYLXANTHINE; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOPOLYSACCHARIDE; MILRINONE; MONTELUKAST; OVALBUMIN; PEPTIDOLEUKOTRIENE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; SODIUM DERIVATIVE; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE N [(2 QUINOLINYL)CARBONYL] O (7 FLUORO 2 QUINOLINYLMETHYL)SODIUM; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD; BRONCHOSPASM; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; DOSE RESPONSE; DRUG DOSE; ENZYME ACTIVITY; EX VIVO STUDY; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; INFLAMMATORY INFILTRATE; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; STANDARD; STATISTICAL SIGNIFICANCE; THROMBOCYTE; TRACHEA;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; CELL DEGRANULATION; GUINEA PIGS; HISTAMINE; HISTAMINE ANTAGONISTS; HUMANS; LEUKOTRIENE D4; MEMBRANE PROTEINS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PARASYMPATHOLYTICS; PEROXIDASE; PHOSPHODIESTERASE INHIBITORS; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, LEUKOTRIENE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 8444235669     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.10.010     Document Type: Article

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