Mapping the subsite preferences of protein tyrosine phosphatase PTP-1B using combinatorial chemistry approaches

Biochemistry

Volumn 37, Issue 45, 1998, Pages 15598-15606

  Pellegrini, Matthew C ^a   Liang, Hongbin ^a   Mandiyan, Sreekala ^a   Wang, Karen ^a   Yuryev, Anton ^a   Vlattas, Isidoros ^a   Sytwu, Teri ^a   Li, Yu Chin ^a   Wennogle, Lawrence P ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; QUANTITATIVE ASSAY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PEPTIDE MAPPING; PHOSPHOPEPTIDES; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY;

EID: 0032506158     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981427+     Document Type: Article

References (11)

1. Walton, K. M., Dixon, J. E. (1993) Protein tyrosine phosphatases. Annu. Rev. Biochem. 62, 101-20.
2. Barford, D., Jia, Z., and Tonks, N. K. (1995) Protein tyrosine phosphatases take off. Nat. Struct. Biol. 2 (12), 1043-53.
3. Guan, K. L. (1990) Dixon, J. E. (1990) Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science 249 (4968), 553-6.
4. Guan, K. L., Broyles, S. S., and Dixon, J. E. (1991) A Tyr/ Ser protein phosphatase encoded by vaccinia virus. Nature 350 (6316), 359-62.
5. Bolin, I.; Wolf-Watz, H. (1988) The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription. Mol. Microbiol. 2 (2), 237-45.
6. Charbonneau, H., et al. (1989) Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-6.
7. Tonks, N. K., Diltz, C. D., Fischer, E. H. (1988) Characterization of the major protein-tyrosine-phosphatases of human placenta. J. Biol. Chem. 263 (14), 6731-7.
8. Tonks, N. K., Diltz, C. D., Fischer, E. H. (1988) Purification of the major protein-tyrosine-phosphatases of human placenta. J. Biol. Chem. 263 (14), 6722-30.
9. Goldstein, B. J. (1996) Protein-Tyrosine Phosphatases and the Regulation of Insulin Action, in Diabetes Mellitus (LeRoith, D., Taylor, S. I., Olefsky, J. M, Eds.) p 174-186, Lippencot-Raven.
10. Kenner, K. A., et al. (1996) Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J. Biol. Chem. 271 (33), 19810-6.
11. Ahmad, F.; Goldstein, B. J. (1995) Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes. Am. J. Physiol. 268 (5 Pt. 1), E932-40.