Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Farmaco

Volumn 59, Issue 11, 2004, Pages 887-892

  Minutolo, Filippo ^a   Antonello, Michela ^a   Barontini, Silvia ^a   Bertini, Simone ^a   Betti, Laura ^b   Danesi, Romano ^a   Gervasi, Gianbattista ^c   Giannaccini, Gino ^b   Papi, Chiara ^a   Placanica, Giorgio ^a   Rapposelli, Simona ^a   Macchia, Marco ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Department of Gynecological   (Italy)

^c Laboratori Baldacci SpA   (Italy)

Author keywords

Enzyme inhibitors; Farnesyltransferase; Geranylgeranyltransferase; Geranylgeranylyldiphosphate

Indexed keywords

ENZYME INHIBITOR; GERANYLGERANYL PROTEIN TRANSFERASE INHIBITOR; GERANYLGERANYL PYROPHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS DERIVATIVE; POTASSIUM SALT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION;

ALKYL AND ARYL TRANSFERASES; DITERPENES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; ORGANOPHOSPHORUS COMPOUNDS; POLYISOPRENYL PHOSPHATES;

EID: 8444220158     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2004.08.002     Document Type: Article

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