Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection

Journal of Viral Hepatitis

Volumn 19, Issue 1, 2012, Pages 23-31

  Luan, Y ^a,b   Ju, J ^a   Luo, L ^c   Zhang, Z ^d   Wang, J ^a,b   Zhu, D M ^a   Cheng, L ^a,b   Zhang, S Y ^d   Chen, L ^a,c   Wang, F S ^d   Wang, S ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BEIJING 302 HOSPITAL   (China)

Author keywords

B7 H3; chronic hepatitis B; HBV; liver cirrhosis; T cell immunity

Indexed keywords

ANTIGEN B7 H3; GAMMA INTERFERON; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CHRONIC DISEASE; CLINICAL TRIAL; DISEASE COURSE; FEMALE; HEPATITIS; HEPATITIS B; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LIVER; LIVER CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; T LYMPHOCYTE;

ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; B7 ANTIGENS; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATOCYTES; HUMANS; LIVER; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84355166799     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2010.01421.x     Document Type: Article

References (31)

1. Rehermann B, Nascimbeni M,. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5 (3): 215-229. (Pubitemid 40364823)
2. Guidotti LG, Chisari FV,. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006; 1: 23-61.
3. Rehermann B, Fowler P, Sidney J, et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995; 181 (3): 1047-1058.
4. Boni C, Fisicaro P, Valdatta C, et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007; 81 (8): 4215-4225. (Pubitemid 46586915)
5. Schlaak JF, Tully G, Lohr HF, Gerken G, Meyer zum Buschenfelde KH,. HBV-specific immune defect in chronic hepatitis B (CHB) is correlated with a dysregulation of pro- and anti-inflammatory cytokines. Clin Exp Immunol 1999; 115 (3): 508-514. (Pubitemid 29130368)
6. Vingerhoets J, Michielsen P, Vanham G, et al. HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B. J Hepatol 1998; 28 (1): 8-16. (Pubitemid 28122494)
7. Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG,. HBV pathogenesis in animal models: recent advances on the role of platelets. J Hepatol 2007; 46 (4): 719-726. (Pubitemid 46400149)
8. Chang JJ, Lewin SR,. Immunopathogenesis of hepatitis B virus infection. Immunol Cell Biol 2007; 85 (1): 16-23. (Pubitemid 46067317)
9. Chen L,. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4 (5): 336-347. (Pubitemid 38649276)
10. Watanabe T, Bertoletti A, Tanoto TA,. PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection. J Viral Hepat 2010; 17 (7): 453-458.
11. Radziewicz H, Hanson HL, Ahmed R, Grakoui A,. Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application? Gastroenterology 2008; 134 (7): 2168-2171. (Pubitemid 351783277)
12. Peng G, Li S, Wu W, Tan X, Chen Y, Chen Z,. PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol 2008; 45 (4): 963-970. (Pubitemid 350019503)
13. Keir ME, Butte MJ, Freeman GJ, Sharpe AH,. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26: 677-704. (Pubitemid 351600389)
14. Mueller SN, Vanguri VK, Ha SJ, et al. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 2010; 120 (7): 2508-2515.
15. Geng L, Jiang G, Fang Y, et al. B7-H1 expression is upregulated in peripheral blood CD14+ monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL-10 levels. J Viral Hepat 2006; 13 (11): 725-733. (Pubitemid 44583497)
16. Zhang Z, Jin B, Zhang JY, et al. Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients. J Hepatol 2009; 50 (6): 1163-1173.
17. Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2 (3): 269-274. (Pubitemid 33706005)
18. Ling V, Wu PW, Spaulding V, et al. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics 2003; 82 (3): 365-377. (Pubitemid 36952307)
19. Prasad DV, Nguyen T, Li Z, et al. Murine B7-H3 is a negative regulator of T cells. J Immunol 2004; 173 (4): 2500-2506. (Pubitemid 39063108)
20. Castriconi R, Dondero A, Augugliaro R, et al. Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc Natl Acad Sci U S A 2004; 101 (34): 12640-12645. (Pubitemid 39122076)
21. Sun Y, Wang Y, Zhao J, et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006; 53 (2): 143-151. (Pubitemid 43994236)
22. Zang X, Thompson RH, Al-Ahmadie HA, et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A 2007; 104 (49): 19458-19463.
23. Boorjian SA, Sheinin Y, Crispen PL, et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res 2008; 14 (15): 4800-4808.
24. Fu J, Xu D, Liu Z, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 2007; 132 (7): 2328-2339. (Pubitemid 46890865)
25. Manning DS, Afdhal NH,. Diagnosis and quantitation of fibrosis. Gastroenterology 2008; 134 (6): 1670-1681. (Pubitemid 351615414)
26. Sun M, Richards S, Prasad DV, Mai XM, Rudensky A, Dong C,. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168 (12): 6294-6297. (Pubitemid 34620050)
27. Steinberger P, Majdic O, Derdak SV, et al. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J Immunol 2004; 172 (4): 2352-2359. (Pubitemid 38182383)
28. Zhou YH, Chen YJ, Ma ZY, et al. 4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells. Tissue Antigens 2007; 70 (2): 96-104.
29. Arribas J, Coodly L, Vollmer P, Kishimoto TK, Rose-John S, Massague J,. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem 1996; 271 (19): 11376-11382. (Pubitemid 26155976)
30. Hemmann S, Graf J, Roderfeld M, Roeb E,. Expression of MMPs and TIMPs in liver fibrosis-a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 2007; 46 (5): 955-975. (Pubitemid 46529049)
31. Leitner J, Klauser C, Pickl WF, et al. B7-H3 is a potent inhibitor of human T-cell activation: no evidence for B7-H3 and TREML2 interaction. Eur J Immunol 2009; 39 (7): 1754-1764.