HBV-specific immune defect in chronic hepatitis B (CHB) is correlated with a dysregulation of pro- and anti-inflammatory cytokines

Clinical and Experimental Immunology

Volumn 115, Issue 3, 1999, Pages 508-514

  Schlaak, J F ^a   Tully, G ^a   Lohr H F ^a   Gerken, G ^a   Meyer Zum Buschenfelde K H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Hepatitis B; IL 10; IL 12; Interferon gamma

Indexed keywords

CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; TETANUS TOXOID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOMODULATION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTIGEN-PRESENTING CELLS; CYTOKINES; DNA, VIRAL; HEPATITIS B ANTIBODIES; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033066049     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00812.x     Document Type: Article

References (27)

1. Penna A, Del Prete G, Cavalli A et al. Predominant T-helper 1 cylokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 1997; 25:1022-7.
2. Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996; 4:25-36.
3. Löhr HF, Weber W, Schlaak JF, Goergen B, Meyer zum Büschenfelde KH, Gerken G. Proliferative response of CD4+ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis Be-minus hepatitis B virus mutants. Hepatology 1995; 22:61-68.
4. Bertoletti A, D'Elios MM, Boni C et al. Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology 1997; 112:193-9.
5. Manetti R, Parronchi P, Giudizi MG et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177:1199-204.
6. Schmitt E, Hoehn P, Hucls C et al. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta. Eur J Immunol 1994; 24:793-8.
7. Kiniwa M, Gately M, Gubler U, Chizzonite R, Fargeas C, Delespesse G. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest 1992; 90:262-6.
8. Becker JC, Brocker EB. Prevention of anergy induction in cloned T cells by interleukin 12. Exp Dermatol 1994; 3:283-9.
9. Kuhns MC, McNamara AL, Perrillo RP, Cabal CM, Campbel CR. Quantitation of hepatitis B viral DNA by solution hybridization: comparison with DNA polymerase and hepatitis Be antigen during antiviral therapy. J Med Virol 1989; 27:274-81.
10. Manns M. Autoamibodies and antigens in liver diseases-updated. J Hepatol 1989; 9:272-80.
11. Schlaak JF, Hermann E, Ringhoffer M et al. Predominance of Th1-type T cells in synovial fluid of patients with Yersinia-induced reactive arthritis. Eur J Immunol 1992; 22:2771-6.
12. Schlaak JF, Nieder P, Meyer zum Büschenfelde KH, Fleischer B. Human T helper cells reactive with somatic bacterial antigens belong to the Th1 subset. Med Microbiol Immunol Berl 1994; 183:169-75.
13. Schlaak JF, Löhr H, Gallati H, Meyer zum Büschenfelde KH, Fleischer B. Analysis of the in vitro cytokine production by liver-infiltrating T cells of patients with autoimmune hepatitis. Clin Exp Immunol 1993; 94:168-73.
14. McHugh SM, Deighton J, Rifkin IR, Ewan PW. Kinetics and functional implications of Th1 and Th2 cytokine production Following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol 1996; 26:1260-5.
15. Cavanaugh VJ, Guidotti LG, Chisari FV. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J Virol 1997; 71:3236-43.
16. Rossol S, Marinos G, Carucci P, Singer MV, Williams R, Naoumov NV. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest 1997; 99:3025-33.
17. Milich DR, Wolf SF, Hughes JL, Jones JE. Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis Be antigen transgenic mice. Proc Natl Acad Sci USA 1995; 92:6847-51.
18. Milich DR, Schodel F, Hughes JL, Jones JE, Peterson DL. The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol 1997; 71:2192-201.
19. Fattovich G, Brollo L, Alberti A, Pontisso P, Giustina G, Realdi G. Long-term follow-up of anti-HBe-positive chronic active hepatitis B. Hepatology 1988; 8:1651-4.
20. Brunetto MR, Oliveri F, Rocca G et al. Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis Be antigen. Hepatology 1989; 10:198-202.
21. Penna A, Artini M, Cavalli A et al. Long-lasting memory T cell responses following self-limited acute hepatitis B. J Clin Invest 1996; 98:1185-94.
22. Cabrerizo M, De Bartolome JSP, Caramelo C, Carreno V. Hepatitis B virus DNA in serum and blood cells of hepatitis B surface antigen-negative hemodialysis patients and staff. J Am Soc Nephrol 1997; 8:1443-7.
23. Michalak TJ, Pasquinelli C, Guilhot S, Chisari FV. Hepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 1994; 94:907.
24. Lee WM. Hepatitis B virus infection. N Engl J Med 1997; 337:1733-45.
25. Santos PJ, Diez RA, Luna CL et al. T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis. Immunol Letters 1996; 50:179-83.
26. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 1997; 26:1530-7.
27. Le MO, De Marchant AGD, Azar C, Goldman M, Deviere J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholics cirrhosis. Hepatology 1995; 22:1436-9.