The immunoregulatory effects of caffeic acid phenethyl ester on the cytokine secretion of peripheral blood mononuclear cells from asthmatic children

Pediatrics and Neonatology

Volumn 52, Issue 6, 2011, Pages 327-331

  Sy, Leticia Bautista ^a,b   Yang, Li King ^a,b   Chiu, Chiau Juno ^c   Wu, Wen Mein ^c  

^a CARDINAL TIEN HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

asthma; caffeic acid phenethyl ester; children; cytokines; immunoregulation

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; ASTHMA; CHILD; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; SUPERNATANT;

ASTHMA; CAFFEIC ACIDS; CHILD; CHILD, PRESCHOOL; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 84355161574     PISSN: 18759572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pedneo.2011.08.005     Document Type: Article

References (25)

1. A.H. Banskota, Y. Tezuka, and S. Kadota Recent progress in pharmacological research of propolis Phytother Res 15 2001 561 571 (Pubitemid 33021859)
2. M.T. Huang, W. Ma, and P. Yen Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 2-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells Carcinogenesis 17 1996 761 765 (Pubitemid 26129690)
3. N. Orsolić, L. Sver, S. Terzic, S. Terzić, and I. Basić Inhibitory effect of water-soluble derivative of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: a possible mode of antitumor action Nutr Cancer 47 2003 156 163 (Pubitemid 38590888)
4. T.W. Chung, S.K. Moon, and Y.C. Chang Novel and therapeutic effect of caffeic acid and caffeic acid phenethyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism FASEB J 18 2004 1670 1681
5. H.C. Kuo, W.H. Kuo, and Y.J. Lee Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo Cancer Lett 234 2006 199 208
6. C. Chiao, A.M. Carothers, and D. Grunberger Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells Cancer Res 55 1995 3576 3583
7. O.K. Mirzoeva, and P.C. Calder The effect of propolis and its components on eicosanoid production during the inflammatory response Prostaglandins Leukot Essent Fatty Acids 55 1996 441 449 (Pubitemid 27014134)
8. L.R. Fitzpatrick, J. Wang, and T. Le Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide- induced colitis in rats J Pharmacol Exp Ther 299 2001 915 920 (Pubitemid 33104959)
9. G.F. Sud'ina, O.K. Mirzoeva, M.A. Pushkareva, G.A. Korshunova, N.V. Sumbatyan, and S.D. Varfolomeev Caffeic acid phenethyl ester as a lipoxygenease inhibitor with antioxidant properties FEBS Lett 329 1993 21 24 (Pubitemid 23248240)
10. M. Yagmurca, H. Erdogan, M. Iraz, A. Sonogur, M. Ucar, and E. Fadillioglu Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats Clin Chim Acta 348 2004 27 34 (Pubitemid 39208997)
11. M. Ogeturk, I. Kus, and N. Colakoglu Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats J Ethnopharmacol 97 2005 273 280 (Pubitemid 40222029)
12. M.K. Ozer, H. Parlakpinar, N. Varadi, Y. Cigremis, M. Ucar, and A. Acet Myocardial ischemia/reperfusion-induced oxidative renal damage in rats: protection by caffeic acid phenethyl ester (CAPE) Shock 24 2005 97 100 (Pubitemid 40946601)
13. S. Ansorge, D. Reinhold, and U. Lenedeckel Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells Z Naturforsch C 58 2003 580 589 (Pubitemid 36971463)
14. N. Marquez, R. Sancho, A. Macho, M.A. Calzado, B.L. Fiebich, and E. Muñoz Caffeic acid phenethyl ester inhibits T-cell activation by targeting both NFAT and NF- kappa B transcription factors J Pharmacol Exp Ther 308 2004 993 1001 (Pubitemid 38263975)
15. J.H. Park, J.K. Lee, and H.S. Kim Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice Int Immunopharmacol 4 2004 429 436 (Pubitemid 38375975)
16. A.B. Kay Allergy and allergic diseases. First of two parts N Engl J Med 344 2001 30 37 (Pubitemid 32064843)
17. A.G. Kaditis, G. Winnie, and G.A. Syrogiannopoulos Anti-inflammatory pharmacotherapy for wheezing in preschool children Pediatr Pulmonol 42 2007 407 420 (Pubitemid 46700939)
18. A.J. Bollet, R. Black, and J.J. Bunim Major undesirable side-effects resulting from prednisolone and prednisone J Am Med Asssoc 158 1955 459 463
19. R. Sorva, M. Turpeinen, K. Juntunen-backman, S.L. Karonen, and A. Sorva Effects of inhaled budesonide on serum markers of bone metabolism in children with asthma J Allergy Clin Immunol 90 1992 808 815
20. O. Gremy, M. Benderitter, and C. Linard Caffeic acid phenethyl ester modifies the TH1/TH2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern World J Gastroenterol 12 2006 4996 5004 (Pubitemid 44323268)
21. M.L. Kuo, J.L. Huang, K.W. Yeh, P.S. Li, and K.H. Hsieh Evaluation of Th1/Th2 ratio and cytokine production profile during acute exacerbation and convalescence in asthmatic children Ann Allergy Asthma Immunol 86 2001 272 276
22. T.R. Mosmann, H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman Two types of murine helper T-cell clone: I-definition according to profiles of lymphokine activities and secreted proteins J Immunol 136 1986 2348 2357 (Pubitemid 16136806)
23. M.G. Roncarolo, R. Bacchetta, C. Bordignon, S. Narula, and M.K. Levings Type 1 T regulatory cells Immunol Rev 182 2001 68 79 (Pubitemid 33070208)
24. + T regulatory cells suppress naïve and memory T-cell proliferation and can be expanded in vitro without loss of function J Exp Med 193 2001 1295 1302
25. M. Larché Regulatory T cells in allergy and asthma Chest 132 2007 1007 1014