Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow

Journal of Cellular Physiology

Volumn 227, Issue 3, 2012, Pages 909-918

  Georgiou, Kristen R ^a,b   Scherer, Michaela A ^a,c   Fan, Chia Ming ^a,b   Cool, Johanna C ^a,b   King, Tristan J ^a,b   Foster, Bruce K ^c   Xian, Cory J ^a,b,c  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN 4; METHOTREXATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY FAT; BODY MASS; BONE DENSITY; BONE DEVELOPMENT; BONE MARROS STROMAL CELL; BONE MARROW; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT F; CONTROLLED STUDY; DRUG EFFECT; EX VIVO STUDY; GENE EXPRESSION; HISTOPATHOLOGY; MALE; METAPHYSIS; NONHUMAN; OSTEOLYSIS; PATHOPHYSIOLOGY; POPULATION SIZE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STROMA CELL; TRABECULAR BONE; TREATMENT DURATION;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BONE DISEASES, METABOLIC; BONE MARROW CELLS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; MALE; METHOTREXATE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; STEM CELLS;

EID: 84155184255     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22807     Document Type: Article

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