Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury

Haematologica

Volumn 92, Issue 7, 2007, Pages 889-896

  Ma, Jie ^a   Shi, Mingxia ^a   Li, Jing ^a   Chen, Bin ^a   Wang, Honglan ^a   Li, Bingzong ^a   Hu, Jianli ^a   Cao, Ying ^a   Fang, Baijun ^a   Zhao, Robert Chunhua ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Bone and hematopoietic injury; Mesenchymal stem cells; Osteogenesis; Senescence; Total body irradiation

Indexed keywords

NERVE CELL ADHESION MOLECULE; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DESTRUCTION; BONE DEVELOPMENT; BONE INJURY; C57BL 6 MOUSE; CELL AGING; CELL DIFFERENTIATION; COLONY FORMING CELL; COLONY FORMING UNIT F; CONTROLLED STUDY; FIBROBLAST; HEMATOPOIESIS; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PROTEIN EXPRESSION; SENESCENCE; SPINDLE CELL; WHOLE BODY RADIATION; ANIMAL; BONE; BONE MARROW; C57BL MOUSE; PHYSIOLOGY; RADIATION EXPOSURE;

ANIMALS; BONE AND BONES; BONE MARROW; CELL AGING; HEMATOPOIESIS; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WHOLE-BODY IRRADIATION;

EID: 34548711765     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.11106     Document Type: Article

References (39)

1. Domen J, Gandy KL, Weissman IL. Systemic overexpression of BCL-2 in the haematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 1998;91:2272-82.
2. Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing radiation and busulfan inhibit murine bone marrow cell haematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol 2003;31:1348-56.
3. Lohrmann H, Schreml W. Long-term haematopoietic damage after cytotoxic drug therapy for solid tumors. In: Testa NG, Gale RP, eds. Haematopoiesis-Long- term effects of chemotherapy and radiation. New York: Marcel Dekker, Inc.; 1988:325-37.
4. Testa NG, Hendry JH, Molineux G. Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anticancer Res 1985;5:101-10.
5. Meng A, Wang Y, Van ZG, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow haematopoietic cells. Cancer Res 2003; 63:5414-9.
6. Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine haematopoietic stem cell senescence. Blood 2006; 107:358-66.
7. Wang X, Hisha H, Taketani S, Adachi Y, Li Q, Cui W, et al. Characterization of mesenchymal stem cells isolated from mouse fetal bone marrow. Stem Cells 2006; 24:482-93.
8. Short B, Brouard N, Occhiodoro-Scott T, Ramakrishnan A, Simmons PJ. Mesenchymal stem cells. Arb Med Res 2003;34:565-71.
9. Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, et al. Reconstitution of the functional human haematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 2006; 107: 1878-87.
10. Galotto M, Berisso G, Delfino L, Podesta M, Ottaggio L, Dallorso S, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol 1999; 27:1460-6.
11. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Systemic infusion of Flk1+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004; 78: 83-8.
12. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31-CD34- progenitors. J Hematother Stem Cell Res 2003; 12:603-13.
13. Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose tissue-derived stem cells dierentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun 2005;332: 370-9.
14. Li J, Shi M, Cao Y, Yuan W, Pang T, Li B, et al. Knockdown of hypoxia-inducible factor-1 alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun 2006; 342-1341-51
15. Zhang J, Niu Ch, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425:836-41.
16. Baxter MA., Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 2004;22:675-82.
17. Mauney JR, Kaplan DL, Volloch V. Matrix-mediated retention of osteogenic differentiation potential by human adult bone marrow stromal cells during ex vivo expansion. Biomaterials 2004;25:3233-43.
18. Chen CS. Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes. BMC Cell Biol 2002; 3:21.
19. Globerson A. Thymocytopoiesis in aging: the bone marrow-thymus axis. Arch Gerontol Geriatr 1997;24:141-55.
20. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-7.
21. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114:1299-307.
22. Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remade J, Toussaint O. Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 2001;276:2531-7.
23. Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 2000; 19:1698-709.
24. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997;89:747-54.
25. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 2005; 309:1074-8.
26. Hopewell JW. Radiation-therapy effects on bone density. Med Pediatr Oncol 2003; 41:208-11.
27. Prockop DJ. Marrow stromal cells as stem cells for nonhaematopoietic tissues. Science 1997;276:71-4.
28. Bonyadi M, Waldman SD, Liu D, Aubin JE, Grynpas MD, Stanford WL. Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice. Proc Natl Acad Sci USA. 2003;100:5840-5.
29. Komori T, Yagi H, Nomura S, Yamaquchi A, Sasaki K, Dequchi K, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997; 89:755-64.
30. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997; 89:765-71.
31. Ducy P. Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 2000; 219:461-71.
32. Beck GR Jr, Zerler B, Moran E. Gene array analysis of osteoblast differentiation. Cell Growth Differ 2001;12:61-8.
33. Castro CH, Shin CS, Stains JP, Cheng SL, Sheikh S, Mbalavieie G, et al. Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J Cell Sci 2004; 117:2853-64.
34. de Oliveira PT, Zalzal SF, Irie K, Nanci A. Early expression of bone matrix proteins in osteogenic cell culture. J Histochem Cytochem 2003; 51:633-41.
35. Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Aging Res Rev 2006; 5: 91-116.
36. Hamilton SA, Pecaut MJ, Gridley DS, Travis ND, Bandstra ER, Willey JS, et al. A murine model for bone loss from therapeutic and space-relevant sources of radiation. J Appl Physiol 2006; 101:789-93.
37. Blair HC, Carrington JL. Bone cell precursors and the pathophysiology of bone loss. Ann N Y Acad Sci 2006; 1068:244-9.
38. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425:841-6.
39. Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Haematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 2004; 103:3258-64.