Hemokinin-1 stimulates prostaglandin E 2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 1, 2012, Pages 27-36

  Dai, Liying ^a   Perera, D Shevy ^b   King, Denis W ^b   Southwell, Bridget R ^c   Burcher, Elizabeth ^a   Liu, Lu ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CYCLOOXYGENASE 2; HEMOKININ 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NOLPITANTIUM; PROSTAGLANDIN E2; SAREDUTANT; SUBSTANCE P; TACHYKININ; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DOWN REGULATION; ENTERITIS; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; EXPLANT; FEMALE; GANGLION; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INFLAMMATORY CELL; MALE; MUSCLE TISSUE; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE; UPREGULATION;

ADULT; AGED; BLOTTING, WESTERN; COLITIS; COLON; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUSCLE, SMOOTH; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STIMULATION, CHEMICAL; TACHYKININS;

EID: 84055219318     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.186155     Document Type: Article

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