Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice

Gut

Volumn 54, Issue 5, 2005, Pages 608-616

  Fornai, M ^a   Blandizzi, C ^a   Colucci, R ^a   Antonioli, L ^a   Bernardini, N ^a   Segnani, C ^a   Baragatti, B ^b   Barogi, S ^b   Berti, P ^a   Spisni, R ^a   Del Tacca, M ^a  

^a UNIVERSITY OF PISA   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 FLUOROPHENYL) 5,5 DIMETHYL 4 (4 METHYLSULFONYLPHENYL) 2(5H) FURANONE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ATROPINE; CARBACHOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; MESSENGER RNA; PROSTAGLANDIN SYNTHASE INHIBITOR; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE; COLON MOTILITY; CONTROLLED STUDY; DESCENDING COLON; ELECTROSTIMULATION; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOTOR PERFORMANCE; MOUSE; MUSCLE CONTRACTILITY; NEUROMUSCULAR FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; COLON; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ELECTRIC STIMULATION; GASTROINTESTINAL MOTILITY; GENE EXPRESSION; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES;

EID: 20244376753     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.053322     Document Type: Article

References (38)

1. O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993;330:156-60.
2. Vane JR, Bakhle YS, Bolting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 1998;38:97-120.
3. MacNaughton WK, Cushing K. Role of constitutive cyclooxygenase-2 in prostaglandin-dependent secretion in mouse colon in vitro. J Pharmacol Exp Ther 2000;293:539-44.
4. Eberhart CE, DuBois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995;109:285-301.
5. Singer II, Kawka DW, Schloemann S, et al. Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology 1998;115:297-306.
6. Halter F, Tarnawski AS, Schmassmann A, et al. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 2001;49:443-53.
7. Subbaramaiah K, Dannenberg AJ. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 2003;24:96-102.
8. Warner TD, Giuliano F, Vojnovic I, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999;96:7563-8.
9. Wallace JL, McKnight W, Reuter BK, et al. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 2000;119:706-14.
10. Northey A, Denis D, Cirino M, et al. Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract. Prostaglandin Other Lipid Mediat 2000;62:145-56.
11. 2 in guinea pig colonic myenteric ganglia. Am J Physiol (Gastrointest Liver Physiol) 2002;283:G1388-97.
12. Porcher C, Horowitz B, Bayguinov O, et al. Constitutive expression and function of cyclooxygenase-2 in murine gastric muscles. Gastroenterology 2002;122:1442-54.
13. Schwarz NT, Kalff JC, Turler A, et al. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology 2001;121:1354-71.
14. Kallf JC, Turler A, Schwarz NT, et al. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 2003;237:301-15.
15. Roberts PJ, Morgan K, Miller R, et al. Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. Gut 2001;48:468-72.
16. Barbara G, De Giorgio R, Deng Y, et al. Role of immunological factors and cyclooxygenase-2 in persistent postinfective enteric muscle dysfunction in mice. Gastroenterology 2001;120:1729-36.
17. Blandizzi C, De Paolis B, Colucci R, et al. Characterization of a novel mechanism accounting for the adverse cholinergic effects of the anticancer drug irinotecan. Br J Pharmacol 2001;132:73-84.
18. Morham SG, Langenbach R, Loftin CD, et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995;83:473-82.
19. Baragatti B, Brizzi F, Ackerley C, et al. Cyclooxygenase-1 and cyclooxygenase-2 in the mouse ductus arteriosus: individual activity and functional coupling with nitric oxide synthase. Br J Pharmacol 2003;139:1505-15.
20. Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A 1992;89:7384-8.
21. Ballou LR, Botting RM, Goorha S, et al. Nociception in cyclooxygenase isozyme-deficient mice. Proc Natl Acad Sci USA 2000;97:10272-6.
22. Bernardini N, Bianchi F, Dolfi A. Lominin and beta1 integrin distribution in the early stages of human kidney development. Nephron 1999;81:289-95.
23. Riendeau D, Percival MD, Boyce S, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol 1997;121:105-17.
24. Koto M, Nishida S, Kitosato H, et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol 2001;53:1679-85.
25. Moggi CA, Giuliani S. Role of tachykinins as excitatory mediators of NANC contraction in the circular muscle of rat small intestine. J Autonom Pharmacol 1995;15:335-50.
26. DuBois RN, Abramson SB, Crofford L. Cyclooxygenase in biology and disease. FASEB J 1998;12:1063-73.
27. Zimmerman KC, Sarbia M, Schror K, et al. Constitutive cyclo-oxygenase-2 expression in healthy human and rabbit gastric mucosa. Mol Pharmacol 1998;54:536-40.
28. Bennett A, Stockley HL. The contribution of prostaglandins in the muscle of human isolated small intestine to neurogenic responses. Br J Pharmacol 1977;61:573-8.
29. Sanders KM. Endogenous prostaglandin E and contractile activity of isolated ileal smooth muscle. Am J Physiol 1978;234:E209-12.
30. Linden DR, Sharkey KA, Ho W, et al. Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. J Physiol 2004;557:1, 191-205.
31. De Backer O, Ledere PG, Lefebvre RA. Pharmacological characterization of pre- and postsynaptic prostanoid receptors in pig gastric fundus. Neuropharmacology 2003;45:684-90.
32. Bennett A, Kenneth GE, Stockley HL. Modulation by prostaglandins of contractions in guinea-pig ileum. Prostaglandins 1975;9:377-84.
33. Takeuchi T, Okuda M, Yagasaki O. The differential contribution of endogenous prostaglandins to the release of acetylcholine from myenteric plexus of the guinea-pig ileum. Br J Pharmacol 1991;102:381-5.
34. Bennett A, Hensby CN, Sanger GJ, et al. Metabolites of arachidonic acid formed by human gastrointestinal tissues and their actions on the muscle layers. Br J Pharmacol 1981;74:435-44.
35. Percy WH, Burton MB, Fallick F, et al. A comparison in vitro of human and rabbit distal colonic muscle responses to inflammatory mediators. Gastroenterology 1990;99:1324-32.
36. Fontoine J, Grivegnee A, Reuse J. Adrenoceptors and regulation of intestinal tone in the isolated colon of the mouse. Br J Pharmacol 1984;81:231-43.
37. Ward SM, Beckett EA, Wang X, et al. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000;20:1393-403.
38. Fintl C, Pearson GT, Ricketts SW, et al. The development and distribution of the interstitial cells of Cajal in the intestine of the equine fetus and neonate. J Anatomy 2004;205:35-44.