Synthesis of 2-(Trifluoromethyl)oxazoles from β-monosubstituted enamines via PhI(OCOCF 3) 2-Mediated trifluoroacetoxylation and cyclization

Journal of Organic Chemistry

Volumn 76, Issue 24, 2011, Pages 10338-10344

  Zhao, Feifei ^a   Liu, Xin ^a   Qi, Rui ^a   Zhang Negrerie, Daisy ^a   Huang, Jianhui ^a   Du, Yunfei ^a   Zhao, Kang ^a  

^a TIANJIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENAMINES; INTRAMOLECULAR CYCLIZATIONS; OXAZOLES; TRIFLUOROACETATES; TRIFLUOROMETHYL;

AMINES;

CYCLIZATION;

(2 IODOPHENYL)[4 METHYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL]METHANONE; (4 CHLOROPHENYL)[4 (4 CHLOROPHENYL) 2 (TRIFLUOROMETHYL)OXAZOL 5 YL]METHANONE; (4 FLUOROPHENYL)[4 METHYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL)METHANONE; 1 AMINO 4,4 DIMETHYL 1 PHENYLPENT 1 EN 3 ONE; 2 (TRIFLUOROMETHYL)OXAZOLE DERIVATIVE; 2,2 DIMETHYL 1 [4 PHENYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL]PROPAN 1 ONE; 3 AMINO 1 (2 IODOPHENYL)BUT 2 EN 1 ONE; 3 AMINO 1 [3 (TRIFLUOROMETHYL)PHENYL]BUT 2 EN 1 ONE; [4 METHYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL](PHENYL)METHANONE; [4 METHYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL][3 (TRIFLUOROMETHYL)PHENYL]METHANONE; [4 TERT BUTYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL](PHENYL)METHANONE; BENZYL 4 METHYL 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; ENAMINE; ETHYL 3 AMINO 4 CYCLOHEXENYLBUT 2 ENOATE; ETHYL 4 (CYCLOHEXENYLMETHYL) 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; ETHYL 4 BENZYL 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; METHYL 4 (2 METHOXYPHENYL) 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; METHYL 4 (4 BROMOPHENYL) 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; METHYL 4 (4 CHLOROPHENYL) 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; METHYL 4 P TOLYL 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; METHYL 4 PHENYL 2 (TRIFLUOROMETHYL)OXAZOLE 5 CARBOXYLATE; OXAZOLE DERIVATIVE; PHENYL[4 PHENYL 2 (TRIFLUOROMETHYL)OXAZOL 5 YL]METHANONE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPLEX FORMATION; CYCLIZATION; DRUG SYNTHESIS; NUCLEOPHILICITY; OXIDATION; PROTON TRANSPORT; REACTION OPTIMIZATION; REACTION TIME; ROOM TEMPERATURE; TRIFLUOROACETOXYLATION;

BIPHENYL COMPOUNDS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXAZOLES; OXIDATION-REDUCTION; TRIFLUOROACETIC ACID;

EID: 84055200054     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo202070h     Document Type: Article

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