Tryptophan 697 modulates hydride and interflavin electron transfer in human methionine synthase reductase

Biochemistry

Volumn 50, Issue 51, 2011, Pages 11131-11142

  Meints, Carla E ^a   Gustafsson, Frida S ^a   Scrutton, Nigel S ^b   Wolthers, Kirsten R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; COFACTORS; CYTOCHROME C; CYTOCHROME P450 REDUCTASE; DRIVING FORCES; ELECTRON TRANSFER; HYDRIDE TRANSFERS; KINETIC BEHAVIOR; KINETIC STEPS; METHIONINE SYNTHASE; MULTIWAVELENGTH; NADPH OXIDATION; OXIDOREDUCTASES; SEMIQUINONES; STOPPED FLOW; TRYPTOPHAN RESIDUES;

AMIDES; BINDING ENERGY; CATALYSIS; ELECTRON TRANSITIONS; HYDRIDES;

AMINO ACIDS;

CYTOCHROME C3; HYDRIDE; HYDROGEN; INTERFLAVIN; ION; METHIONINE SYNTHASE REDUCTASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEMIQUINONE; SERINE DERIVATIVE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ELECTRON TRANSPORT; ENERGY; ENZYME METABOLISM; HUMAN; NONHUMAN; OXIDATION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; STEADY STATE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BIOCATALYSIS; ELECTRON TRANSPORT; FERREDOXIN-NADP REDUCTASE; FLAVIN MONONUCLEOTIDE; FLAVIN-ADENINE DINUCLEOTIDE; FLAVINS; FLAVOPROTEINS; HUMANS; HYDROGEN; KINETICS; MUTANT PROTEINS; NAD; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; TRYPTOPHAN;

EID: 84055184455     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2012228     Document Type: Article

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