Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis

Clinical Science

Volumn 112, Issue 9-10, 2007, Pages 499-506

  Klaude, Maria ^a   Fredriksson, Katarina ^a   Tjäder, Inga ^a   Hammarqvist, Folke ^a   Ahlman, Bo ^b   Rooyackers, Olav ^a   Wernerman, Jan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b ERSTA HOSPITAL   (Sweden)

Author keywords

Multiple organ dysfunction; Muscle wasting; Proteasome; Protein degradation; Sepsis; Skeletal muscle

Indexed keywords

PROTEASOME;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MUSCLE ATROPHY; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEPSIS; SKELETAL MUSCLE; SYNTHESIS; BIOPSY; BREATHING MUSCLE; CACHEXIA; ENZYMOLOGY; LEG; METABOLISM; MIDDLE AGED; MULTIPLE ORGAN FAILURE;

AGED; BIOPSY; CACHEXIA; FEMALE; HUMANS; LEG; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MUSCLE, SKELETAL; PROTEASOME ENDOPEPTIDASE COMPLEX; RESPIRATORY MUSCLES; SEPSIS;

EID: 34248574060     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20060265     Document Type: Article

References (32)

1. Essen, P., McNurlan, M. A., Gamrin, L. et al. (1998) Tissue protein synthesis rates in critically ill patients. Crit. Care Med. 26, 92-100
2. Gamrin, L., Essen, P., Hultman, E., McNurlan, M. A., Garlick, P. J. and Wernerman, J. (2000) Protein sparing effect in skeletal muscle of growth hormone treatment in critically ill patients. Ann. Surg. 231, 577-586
3. Tjader, I., Rooyackers, O., Forsberg, A. M., Vesali, R. F., Garlick, P. J. and Wernerman, J. (2004) Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients. Intensive Care Med. 30, 266-275
4. Jagoe, R. T. and Goldberg, A. L. (2001) What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr. Opin. Clin. Nutr. Metab. Care 4, 183-190
5. Kisselev, A. F., Akopian, T. N., Castillo, V. and Goldberg, A. L. (1999) Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. Mol. Cell 4, 395-402
6. Medina, R., Wing, S. S. and Goldberg, A. L. (1995) Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy. Biochem. J. 307, 631-637
7. Hobler, S. C., Williams, A., Fischer, D. et al. (1999) Activity and expression of the 20 S proteasome are increased in skeletal muscle during sepsis. Am. J. Physiol. 46, R434-R440
8. Price, S. R., Bailey, J. L., Wang, X. et al. (1996) Muscle wasting in insulinopenic rats results from activation of the ATP dependent ubiquitin-proteasome pathway by a mechanism including gene transcription. J. Clin. Invest. 98, 1703-1708
9. Auclair, D., Garrel, D. R., Chaouki Zerouala, A. and Ferland, L. H. (1997) Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids. Am. J. Physiol. 272, C1007-C1016
10. 2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients. Proc. Natl. Acad. Sci. U.S.A. 93, 2714-2718
11. Biolo, G., Bosutti, A., Iscra, F., Toigo, G., Gullo, A. and Guarnieri, G. (2000) Contribution of the ubiquitin-pCI-neo proteasome pathway to overall muscle proteolysis in hypercatabolic patients. Metab., Clin. Exp. 49, 689-691
12. Williams, A., Sun, X., Fischer, J. E. and Hasselgren, P. O. (1999) The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer. Surgery 126, 744-749
13. Khal, J., Hine, A. V., Fearon, K. C. H., Dejong, C. H. C. and Tisdale, M. J. (2005) Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss. Int. J. Biochem. Cell Biol. 37, 2196-2206
14. Tiao, G., Hobler, S., Wang, J. J. et al. (1997) Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J. Clin. Invest. 99, 163-168
15. Fang, C. H., Li, B. G., Fischer, D. R. et al. (2000) Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle. Clin. Sci. 99, 181-187
16. Bossola, M., Muscaritoli, M., Costelli, P. et al. (2003) Increased muscle proteasome activity correlates with disease severity in gastric cancer patients. Ann. Surg. 237, 384-389
17. Klaude, M., Hammarqvist, F. and Wernerman, J. (2005) An assay of microsomal membrane-associated proteasomes demonstrates increased proteolytic activity in skeletal muscle of intensive care unit patients. Clin. Nutr. 24, 259-265
18. Tobin, M. J., Laghi, F. and Jubran, A. (1998) Respiratory muscle dysfunction in mechanically-ventilated patients. Mol. Cell. Biochem. 179, 87-98
19. Vincent, J. L., Moreno, R., Takala, J. et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 22, 707-710
20. Bone, R. C., Balk, R. A., Cerra, F. B. et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101, 1644-1655
21. Cerqueira, E. P. and Garbellini, D. (1999) Electromyographic study of the pectoralis major, serratus anterior and external oblique muscles during respiratory activity in humans. Electromyogr. Clin. Neurophysiol. 39, 131-137
22. Rodgers, K. J. and Dean, R. T. (2003) Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates. Int. J. Biochem. Cell. Biol. 35, 716-727
23. Gamrin, L., Andersson, K., Hultman, E., Nilsson, E., Essén, P. and Wernerman, J. (1997) Longitudinal changes of biochemical parameters in muscle during critical illness. Metab., Clin. Exp. 46, 756-762
24. Schimbara, N., Orino, E., Sone, S. et al. (1992) Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells. J. Biol. Chem. 267, 18100-18109
25. Dahlmann, B., Ruppert, T., Kloetzel, P. M. and Kuehn, L. (2001) Subtypes of 20 S proteasomes from skeletal muscle. Biochimie 83, 295-299
26. Merforth, S., Kuehn, L., Osmers, A. and Dahlmann, B. (2003) Alteration of 20 S proteasome-subtypes and proteasome activator PA28 in skeletal muscle of rat after induction of diabetes mellitus. Int. J. Biochem. Cell. Biol. 35, 740-748
27. Ottenheijm, C. A. C., Heunks, L. M. A., Sieck, G. C. et al. (2005) Diaphragm dysfunction in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 172, 200-205
28. Shanely, R. A., Zergeroglu, M. A., Lennon, S. L. et al. (2002) Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am. J. Respir. Crit. Care Med. 166, 1369-1374
29. Betters, J. L., Criswell, D. S., Shanely, R. A. et al. (2004) Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis. Am. J. Respir. Crit. Care Med. 170, 1179-1184
30. Tjader, I., Rooyackers, O., Klaude, M., Nennesmo, I. and Wernerman, J. (2005) Reproducibility in skeletal muscle protein synthesis rate in intensive care patients. Clin. Nutr. 24, 611
31. Serrano, A. L., Pérez, M., Lucía, A., Chicharro, J. L., Quiroz-Rothe, E. and Rivero, J. L. L. (2001) Immunolabelling, histochemistry and in situ hybridisation in human skeletal muscle fibres to detect myosin heavy chain expression at the protein and mRNA level. J. Anat. 199, 329-337
32. Lexell, J., Henriksson-Larsén, K. and Sjostrom, M. (1983) Distribution of different fibre types in human skeletal muscles. Acta Physiol. Scand. 117, 115-122