Cell adhesion molecules contribute to Alzheimer's disease: Multiple pathway analyses of two genome-wide association studies

Journal of Neurochemistry

Volumn 120, Issue 1, 2012, Pages 190-198

  Liu, Guiyou ^a   Jiang, Yongshuai ^b   Wang, Ping ^a   Feng, Rennan ^b   Jiang, Nan ^a   Chen, Xiaoyun ^a   Song, Hui ^a   Chen, Zugen ^c  

^a Chinese Academy of Sciences   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; cell adhesion molecules; complex neurological disorder; genome wide association studies; multiple testing correction; pathway analysis

Indexed keywords

CELL ADHESION MOLECULE;

ALZHEIMER DISEASE; ANALYTIC METHOD; ARTICLE; DATA BASE; DISCOVERY DATASET; DISEASE PREDISPOSITION; FISHER EXACT TEST; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOME; GENOME ANALYSIS; HYPERGEOMETRIC TEST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; VALIDATION DATASET; Z STATISTIC TEST;

ALGORITHMS; ALZHEIMER DISEASE; CELL ADHESION MOLECULES; DATA MINING; DATABASES, GENETIC; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FRANCE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 83855165649     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07547.x     Document Type: Article

References (68)

1. Abraham R., Moskvina V., Sims R., et al. (2008) A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med. Genomics 1, 44.
2. Aisa B., Gil-Bea F. J., Solas M., Garcia-Alloza M., Chen C. P., Lai M. K., Francis P. T., and, Ramirez M. J., (2010) Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. J. Alzheimers Dis. 20, 659-668.
3. Bertram L., and, Tanzi R. E., (2010) Alzheimer disease: New light on an old CLU. Nat. Rev. Neurol. 6, 11-13.
4. Bot N., Schweizer C., Ben Halima S., and, Fraering P. C., (2011) Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases. J. Biol. Chem. 286, 2762-2773.
5. Briggs F. B., Shao X., Goldstein B. A., Oksenberg J. R., Barcellos L. F., and, De Jager P. L., (2011) Genome-wide association study of severity in multiple sclerosis. Genes Immun. [Epub ahead of print].
6. Bullard D. C., (2002) Adhesion molecules in inflammatory diseases: insights from knockout mice. Immunol. Res. 26, 27-33. (Pubitemid 35177481)
7. Chekhonin V. P., Shepeleva I. I., and, Gurina O. I., (2008) Disturbances in the expression of neuronal cell adhesion proteins NCAM. Clin. Aspects Neurochem. J. 2, 239-251.
8. Chen Q., Kimura H., and, Schubert D., (2002) A novel mechanism for the regulation of amyloid precursor protein metabolism. J. Cell Biol. 158, 79-89.
9. Crews L., and, Masliah E., (2010) Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum. Mol. Genet. 19, R12-R20.
10. Di Paola R., Talero E., Galuppo M., Mazzon E., Bramanti P., Motilva V., and, Cuzzocrea S., (2011) Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis. Respir. Res. 12, 41.
11. Elbers C. C., van Eijk K. R., Franke L., Mulder F., van der Schouw Y. T., Wijmenga C., and, Onland-Moret N. C., (2009) Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genet. Epidemiol. 33, 419-431.
12. Elks C. E., Perry J. R., Sulem P., et al. (2010) Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat. Genet. 42, 1077-1085.
13. Ewers M., Mielke M. M., and, Hampel H., (2010) Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp. Gerontol. 45, 75-79.
14. Foley A. G., Prendergast A., Barry C., Scully D., Upton N., Medhurst A. D., and, Regan C. M., (2009) H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms. Neuropsychopharmacology 34, 2585-2600.
15. Fujita E., Dai H., Tanabe Y., Zhiling Y., Yamagata T., Miyakawa T., Tanokura M., Momoi M. Y., and, Momoi T., (2010) Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Dis. 1, e47.
16. Golias C., Tsoutsi E., Matziridis A., Makridis P., Batistatou A., and, Charalabopoulos K., (2007) Review. Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease. In Vivo 21, 757-769.
17. Grammas P., (2011) Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J. Neuroinflammation 8, 26.
18. Harold D., Abraham R., Hollingworth P., et al. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088-1093.
19. Harris M. A., Clark J., Ireland A., et al. (2004) The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res. 32, D258-D261. (Pubitemid 38081651)
20. Hochstrasser T., Weiss E., Marksteiner J., and, Humpel C., (2010) Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment. Exp. Gerontol. 45, 70-74.
21. Holmans P., Green E. K., Pahwa J. S., Ferreira M. A., Purcell S. M., Sklar P., Owen M. J., O'Donovan M. C., and, Craddock N., (2009) Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am. J. Hum. Genet. 85, 13-24.
22. Hong M. G., Alexeyenko A., Lambert J. C., Amouyel P., and, Prince J. A., (2010) Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease. J. Hum. Genet. 55, 707-709.
23. Hooli B. V., and, Tanzi R. E., (2009) A current view of Alzheimer's disease. F1000 Biol. Rep. 1, 54.
24. Hu X., Pickering E., Liu Y. C., et al. (2011) Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. PLoS ONE 6, e16616.
25. Hua S., Hermanussen S., Tang L., Monteith G. R., and, Cabot P. J., (2006) The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons. Anesth. Analg. 103, 1558-1564. (Pubitemid 44949229)
26. Huang da W., Sherman B. T., and, Lempicki R. A., (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
27. Jia P., Wang L., Meltzer H. Y., and, Zhao Z., (2010) Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr. Res. 122, 38-42.
28. Jia P., Wang L., Meltzer H. Y., and, Zhao Z., (2011) Pathway-based analysis of GWAS datasets: effective but caution required. Int. J. Neuropsychopharmacol. 14, 567-572.
29. Jin K., Peel A. L., Mao X. O., Xie L., Cottrell B. A., Henshall D. C., and, Greenberg D. A., (2004) Increased hippocampal neurogenesis in Alzheimer's disease. Proc. Natl. Acad. Sci. U S A 101, 343-347. (Pubitemid 38084252)
30. Jones L., Holmans P. A., Hamshere M. L., et al. (2010) Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5, e13950.
31. Kanehisa M., and, Goto S., (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27-30. (Pubitemid 30047706)
32. Kim S. Y., and, Volsky D. J., (2005) PAGE: parametric analysis of gene set enrichment. BMC Bioinformatics 6, 144.
33. Lambert J. C., Heath S., Even G., et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41, 1094-1099.
34. Lambert J. C., Grenier-Boley B., Chouraki V., et al. (2010) Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis. J. Alzheimers Dis. 20, 1107-1118.
35. Laurila J. P., Laatikainen L. E., Castellone M. D., and, Laukkanen M. O., (2009) SOD3 reduces inflammatory cell migration by regulating adhesion molecule and cytokine expression. PLoS ONE 4, e5786.
36. Malm T., Koistinaho M., Muona A., Magga J., and, Koistinaho J., (2010) The role and therapeutic potential of monocytic cells in Alzheimer's disease. Glia 58, 889-900.
37. Mattson M. P., and, van Praag H., (2008) TAGing APP constrains neurogenesis. Nat. Cell Biol. 10, 249-250. (Pubitemid 351331008)
38. Mi H., Lazareva-Ulitsky B., Loo R., et al. (2005) The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res. 33, D284-D288. (Pubitemid 40207879)
39. Morange P. E., Bezemer I., Saut N., et al. (2010) A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. Am. J. Hum. Genet. 86, 592-595.
40. Moss M. A., Gonzalez-Velasquez F. J., Reed J. W., Fuseler J. W., Matherly E. E., Kotarek J. A., and, Soto-Ortega D. D., (2010) Soluble amyloid-beta protein aggregates induce nuclear factor-kappa b mediated upregulation of adhesion molecule expression to stimulate brain endothelium for monocyte adhesion. J. Adhes. Sci. Technol. 24, 2105-2126.
41. Naj A. C., Beecham G. W., Martin E. R., et al. (2010) Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PLoS Genet. 6, e1001130.
42. Nam D., Kim J., Kim S. Y., and, Kim S., (2010) GSA-SNP: a general approach for gene set analysis of polymorphisms. Nucleic Acids Res. 38, W749-754.
43. O'Dushlaine C., Kenny E., Heron E., Donohoe G., Gill M., Morris D., and, Corvin A., (2010) Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol. Psychiatry 16, 286-292.
44. Osterfield M., Egelund R., Young L. M., and, Flanagan J. G., (2008) Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development 135, 1189-1199. (Pubitemid 351578147)
45. Pedersen N. L., (2010) Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment. JAMA 303, 1864-1865.
46. Perry J. R., McCarthy M. I., Hattersley A. T., Zeggini E., Weedon M. N., and, Frayling T. M., (2009) Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes 58, 1463-1467.
47. Purcell S., Neale B., Todd-Brown K., et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575. (Pubitemid 47330214)
48. Raychaudhuri S., Plenge R. M., Rossin E. J., et al. (2009) Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 5, e1000534.
49. Segre A. V., Groop L., Mootha V. K., Daly M. J., and, Altshuler D., (2010) Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet. 6, e1001058.
50. Seshadri S., DeStefano A. L., Au R., et al. (2007) Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med. Genet. 8 (Suppl. 1), S15.
51. Seshadri S., Fitzpatrick A. L., Ikram M. A., et al. (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303, 1832-1840.
52. Speliotes E. K., Willer C. J., Berndt S. I., et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948.
53. Stein J. L., Hua X., Morra J. H., et al. (2010) Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. Neuroimage 51, 542-554.
54. Strekalova H., Buhmann C., Kleene R., Eggers C., Saffell J., Hemperly J., Weiller C., Muller-Thomsen T., and, Schachner M., (2006) Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. Neurobiol. Aging 27, 1-9. (Pubitemid 41627943)
55. Takei N., Miyashita A., Tsukie T., et al. (2009) Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics 93, 441-448.
56. Thomas P. D., Campbell M. J., Kejariwal A., Mi H., Karlak B., Daverman R., Diemer K., Muruganujan A., and, Narechania A., (2003) PANTHER: a library of protein families and subfamilies indexed by function. Genome Res. 13, 2129-2141. (Pubitemid 37161770)
57. Vastrik I., D'Eustachio P., Schmidt E., et al. (2007) Reactome: a knowledge base of biologic pathways and processes. Genome Biol. 8, R39.
58. Voight B. F., Scott L. J., Steinthorsdottir V., et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42, 579-589.
59. Walter S., Atzmon G., Demerath E. W., et al. (2011) A genome-wide association study of aging. Neurobiol. Aging 32, 2109 e2115-2128.
60. Wang K., Li M., and, Bucan M., (2007) Pathway-based approaches for analysis of genomewide association studies. Am. J. Hum. Genet. 81, 1278-1283. (Pubitemid 350211456)
61. Wang K., Zhang H., Ma D., et al. (2009) Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 459, 528-533.
62. Wang K., Li M., and, Hakonarson H., (2010) Analysing biological pathways in genome-wide association studies. Nat. Rev. Genet. 11, 843-854.
63. Wang L., Jia P., Wolfinger R. D., Chen X., and, Zhao Z., (2011) Gene set analysis of genome-wide association studies: Methodological issues and perspectives. Genomics 98, 1-8.
64. Waring S. C., and, Rosenberg R. N., (2008) Genome-wide association studies in Alzheimer disease. Arch. Neurol. 65, 329-334. (Pubitemid 351409357)
65. Ye H., Liu J., and, Wu J. Y., (2010) Cell adhesion molecules and their involvement in autism spectrum disorder. Neurosignals 18, 62-71.
66. Zhang B., Kirov S., and, Snoddy J., (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 33, W741-748. (Pubitemid 44530021)
67. Zhang K., Cui S., Chang S., Zhang L., and, Wang J., (2010) i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res. 38, W90-95.
68. Zuliani G., Cavalieri M., Galvani M., Passaro A., Munari M. R., Bosi C., Zurlo A., and, Fellin R., (2008) Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia. J. Neurol. Sci. 272, 164-170.