Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behavior

Endocrine Development

Volumn 20, Issue , 2010, Pages 137-148

  DeRijk, Roel H ^a   De Kloet, E Ron ^a   Zitman, Frans G ^a   Van Leeuwen, Nienke ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID RECEPTOR; DEXAMETHASONE; HYDROCORTISONE; MINERALOCORTICOID RECEPTOR;

ARTICLE; BEHAVIOR; COHORT ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERIATRIC PATIENT; HAPLOTYPE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; MENTAL DISEASE; NEUROENDOCRINE SYSTEM; NEUROSIS; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; STRESS; TRANSACTIVATION;

ADAPTATION, PSYCHOLOGICAL; AGED; ANIMALS; BEHAVIOR; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, BIOLOGICAL; MUTANT PROTEINS; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, MINERALOCORTICOID;

EID: 78751539216     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000321235     Document Type: Article

References (23)

1. De Kloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005;6:463-475.
2. Funder JW: Mineralocorticoid receptors: distribution and activation. Heart Fail Rev 2005;10:15-22.
3. DeRijk RH: Single nucleotide polymorphisms related to HPA axis reactivity Neuroimmunomodulation 2009;16:340-352.
4. Pascual-Le Tallec L, Lombes M: The mineralocorticoid receptor: a journey exploring its diversity and specificity of action. Mol Endocrinol 2005;19:2211-2221.
5. Tasker JG, Di S, Malcher-Lopes R: Rapid glucocorticoid signaling via membrane-associated receptors. Endocrinology 2006;147:5549-5556.
6. Joels M, Karst H, Derijk R, de Kloet ER: The coming out of the brain mineralocorticoid receptor. Trends Neurosci 2008;31:1-7.
7. Oitzl MS, Champagne DL, van der Veen R, de Kloet ER: Brain development under stress: hypotheses of glucocorticoid actions revisited. Neurosci Biobehav Rev 2010;34:853-866.
8. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE: Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010;167:509-527.
9. DeRijk RH, de Kloet ER: Corticosteroid receptor genetic polymorphism and stress responsivity. Endocrine 2005;28:263-270.
10. De Kloet ER, DeRijk RH, Meijer OC: Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? Nat Clin Pract Endocrinol Metab 2007;3: 168-179.
11. DeRijk RH, Wust S, Meijer OC, Zennaro M-C, Federenko IS, Hellhammer DH, Giacchetti G, Vreugdenhil E, Zitman FG, de Kloet ER: A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab 2006;91:5083-5089.
12. van Leeuwen N, Caprio M, Blaya C, Fumeron F, Sartorato P, Ronconi V, Giacchetti G, Mantero F, Fernandes-Rosa FL, Simian C, Peyrard S, Zitman FG, Penninx BW, de Kloet ER, Azizi M, Jeunemaitre X, DeRijk RH, Zennaro MC: Hypertension 2010; 56:995-1002. Epub 2010.
13. Van Leeuwen N, Kumsta R, Entringer S, de Kloet ER, Zitman FG, DeRijk RH, Wust S: Functional MR gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology 2009;35:339-349.
14. Van Leeuwen N, Bellingrath S, de Kloet ER, Zitman FG, Kudielka BM, DeRijk RH, Wust S: Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response. Psychoneuroendocrinology 2010. In press.
15. Kuningas M, DeRijk RH, Westendorp RG, Jolles J, Slagboom EP, van Heemst D: Mental performance in old age is dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 2007;32: 1295-1301.
16. Wilhelm I, Born J, Kudielka BM, Schlotz W, Wust S: Is the cortisol awakening rise a response to awakening? Psychoneuroendocrinology 2007;32:358-366.
17. Lai M, Horsburgh K, Bae SE, Carter RN, Stenvers DJ, Fowler JH, Yau JL, Gomez-Sanchez CE, Holmes MC, Kenyon CJ, Seckl JR, MacLeod MR: Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia. Eur J Neurosci 2007;25: 1832-1842.
18. Rozeboom AM, Akil H, Seasholtz AF: Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice. Proc Natl Acad Sci USA 2007;104:4688-4693.
19. Berger S, Wolfer DP, Selbach O, Alter O, Erdmann G, Reichard HM, Chepkova AN, Welzl H, Haas HL, Lipp H-P, Schutz G: Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci USA 2006;103:195-200.
20. Otte C, Moritz S, Yassouridis A, Koop M, Madrischewski AM, Wiedemann K, Kellner M: Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition. Neuropsychopharmacology 2007;32:232-328.
21. Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S, Horstmann S, Uhr M, Muller-Myhsok B, Holsboer F: Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 2008;28:389-398.
22. De Beurs E, Hollander-Gijsman ME, Helmich S, Zitman FG: The tripartite model for assessing symptoms of anxiety and depression: psychometrics of the Dutch version of the mood and anxiety symptoms questionnaire. Behav Res Ther 2006;45:1609-1617.
23. Portella MJ, Harmer CJ, Flint J, Cowen P, Goodwin GM: Enhanced early morning salivary cortisol in neuroticism. Am J Pschiatry 2005;162:807-809.