Tissue-specific expression of α and β messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 5, 1997, Pages 1345-1352

  Zennaro, Maria Christina ^a,b   Farman, Nicolette ^a   Bonvalet, Jean Pierre ^a   Lombès, Marc ^a  

^a INSERM   (France)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; COLON MUCOSA; CONTROLLED STUDY; EXON; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERALDOSTERONISM; IN SITU HYBRIDIZATION; KERATINOCYTE; KIDNEY TUBULE; PRIORITY JOURNAL; PSEUDOHYPOALDOSTERONISM; RNA PROBE; RNA TRANSCRIPTION; SWEAT GLAND; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 0030918425     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.5.3933     Document Type: Article

References (28)

1. Evans RM. The steroid and thyroid hormone receptor superfamily. 1988 Science. 240:889-895.
2. Verrey F. 1995 Transcriptional control of sodium transport in tight epithelia by adrenal steroids. J Membr Biol. 144:93-110.
3. Funder JW, Feldman D, Edelman IS. 1972 Specific aldosterone binding in rat kidney and parotid. J Steroid Biochem. 3:209-218.
4. Farman N, Oblin ME, Lombès M, et al. 1991 Immunolocalization of gluco and mineralocorticoid receptors in the rabbit kidney. Am J Physiol. 260:C226-C233.
5. Pressley LA, Funder JW. 1975 Glucocorticoid and mineralocorticoid receptors in gut mucosa. Endocrinology. 97:588-596.
6. Rafestin-Oblin ME, Lombès M, Michel JB, Michaud A, Claire M. 1984 Mineralocorticoid receptors in the epithelial cells of human colon and ileum. J Steroid Biochem. 20:311-315.
7. Kenouch S, Lombès M, Delahaye F, Eugène E, Bonvalet JP, Farman N. 1994 Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11b-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab. 79:1334-1341.
8. DeKloet ER, Wallach G, McEwen BS. 1975 Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology. 96:598-609.
9. Reul JMHM, de Kloet ER. 1985 Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 117:2505-2512.
10. Armanini D, Strasser T, Weber PC. 1985 Characterization of aldosterone binding sites in circulating human mononuclear leukocytes. Am J Physiol 248:E288-E290.
11. Meyer WJI, Nichols N. 1981 Mineralocorticoid binding in cultured smooth muscle cells and fibroblast from rat aorta. J Steroid Biochem. 14:1157-1168.
12. Pearce P, Funder JW. 1987 High affinity aldosterone binding sites (Type I receptors) in rat heart. J Clin Exp Pharmacol Physiol. 14:859-866.
13. Lombès M, Oblin M-E, Gasc JM, Baulieu EE, Farman N, Bonvalet J-P. 1992 Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res. 71:503-510.
14. Armanini D, Witzgall H, Wehling M, Kuhle U, Weber PC. 1987 Aldosterone receptors in different types of primary hyperaldosteronism. J Clin Endocrinol Metab. 65:101-104.
15. Armanini D, Zennaro M-C, Martella L, Scali M, Pratesi C, Grella PV, Mantero F. 1992 Mineralocorticoid effector mechanism in preeclampsia. J Clin Endocrinol Metab. 744:946-949.
16. Zennaro M-C, Keightley MC, Kotelevtsev Y, Conway G, Soubrier F, Fuller PJ. 1995 Human mineralocorticoid receptor genomic structure and identification of expressed isoforms. J Biol Chem. 270:21016-21020.
17. Schibler U, Sierra F. 1987 Alternative promoters in developmental gene expression. Ann Rev Genet. 21:237-257.
18. Zennaro M-C, Le Menuet D, Lombès M. 1996 Characterization of the human mineralocorticoid receptor gene 5′-regulatory region: evidence for differential hormonal regulation of two alternative promoters via non-classical mechanisms. Mol Endocrinol. 10:1549-1560.
19. Kwak SP, Patel PD, Thompson RC, Akil H, Watson SJ. 1993 5′-heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within rat hippocampus. Endocrinology. 133:2344-2350.
20. Lombès M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet J-P. 1995 Prerequisite for cardiac aldosterone action: mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase in the human heart. Circulation. 922:175-182.
21. Strähle U, Schmidt A, Kelsey G, et al. 1992 At least three promoters direct expression of the mouse glucocorticoid receptor gene. Proc Natl Acad Sci USA. 89:6731-6735.
22. Lopez AJ. 1995 Developmental role of transcription factor isoforms generated by alternative splicing. Dev Biol. 172:396-411
23. Gordon RD. 1995 Heterogeneous hypertension. Nature Genetics. 11:6-9.
24. Schimkets RA, Warnock DG, Bositis CM, et al. 1994 Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell. 79:407-414.
25. Hansson JH, Nelson-Williams C, Suzuki H, et al. 1995 Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle's syndrome. Nature Genetics. 11:76-82.
26. Komesaroff PA, Zennaro M-C. 1995 Glucocorticoid and mineralocorticoid resistance. J Endocrinol Invest. 18:550-565.
27. Komesaroff P, Verity K, Fuller PJ. 1994 Pseudohypoaldosteronism: molecular characterisation of the mineralocorticoid receptor. J Clin Endocrinol Metab. 79:27-31.
28. Zennaro MC, Borensztein P, Jeunemaitre X, Armanini D, Soubrier F. 1994 No alteration in the primary structure of the mineralocorticoid receptor in a family with pseudohypoaldosteronism. J Clin Endocrinol Metab. 79:32-38.