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Volumn 10, Issue , 2011, Pages

The O-mannosylation and production of recombinant APA (45/47 KDa) protein from Mycobacterium tuberculosis in Streptomyces lividans is affected by culture conditions in shake flasks

Author keywords

Apa 45 47 kda; Mycobacterium tuberculosis; O mannosylation; Oxygenation; Shake flasks; Shear; Streptomyces lividans

Indexed keywords

MANNOSE; RECOMBINANT ALA PRO RICH ANTIGEN PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GLYCOPROTEIN;

EID: 83655211813     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-10-110     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 77649209520 scopus 로고    scopus 로고
    • Diagnosis of tuberculosis in developing countries: new perspectives
    • Dubrous P, Alaoui H, N'Dounga MB, Koeck JL. Diagnosis of tuberculosis in developing countries: new perspectives. Med Trop (Mars ) 2009, 69:618-628.
    • (2009) Med Trop (Mars ) , vol.69 , pp. 618-628
    • Dubrous, P.1    Alaoui, H.2    N'Dounga, M.B.3    Koeck, J.L.4
  • 2
    • 77049083451 scopus 로고    scopus 로고
    • Diagnosis of drug-resistant tuberculosis: reliability and rapidity of detection
    • Van DA, Martin A, Palomino JC. Diagnosis of drug-resistant tuberculosis: reliability and rapidity of detection. Int J Tuberc Lung Dis 2010, 14:131-140.
    • (2010) Int J Tuberc Lung Dis , vol.14 , pp. 131-140
    • Van, D.A.1    Martin, A.2    Palomino, J.C.3
  • 3
    • 79961009002 scopus 로고    scopus 로고
    • Transforming the global tuberculosis response through effective engagement of civil society organizations: the role of the World Health Organization
    • 10.2471/BLT.11.086801, 3150765, 21836760
    • Getahun H, Raviglione M. Transforming the global tuberculosis response through effective engagement of civil society organizations: the role of the World Health Organization. Bull World Health Organ 2011, 89:616-618. 10.2471/BLT.11.086801, 3150765, 21836760.
    • (2011) Bull World Health Organ , vol.89 , pp. 616-618
    • Getahun, H.1    Raviglione, M.2
  • 4
    • 77952361109 scopus 로고    scopus 로고
    • New insights into protein O-mannosylation in actinomycetes
    • 10.1039/b916394h, 20567761
    • Espitia C, Servín-González L, Mancilla R. New insights into protein O-mannosylation in actinomycetes. Mol Biosyst 2010, 6:775-81. 10.1039/b916394h, 20567761.
    • (2010) Mol Biosyst , vol.6 , pp. 775-781
    • Espitia, C.1    Servín-González, L.2    Mancilla, R.3
  • 5
  • 6
    • 77950595167 scopus 로고    scopus 로고
    • Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host
    • Torrelles JB, Schlesinger LS. Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host. Tuberculosis (Edinb) 2010, 90:84-93.
    • (2010) Tuberculosis (Edinb) , vol.90 , pp. 84-93
    • Torrelles, J.B.1    Schlesinger, L.S.2
  • 7
    • 0029896457 scopus 로고    scopus 로고
    • Bacterial glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis
    • 451952, 8670858
    • Herrmann JL, O'Gaora P, Gallagher A, Thole JE, Young DB. Bacterial glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis. EMBO J 1996, 15:3547-3554. 451952, 8670858.
    • (1996) EMBO J , vol.15 , pp. 3547-3554
    • Herrmann, J.L.1    O'Gaora, P.2    Gallagher, A.3    Thole, J.E.4    Young, D.B.5
  • 8
    • 0037378089 scopus 로고    scopus 로고
    • The Apa protein of Mycobacterium tuberculosis stimulates gamma interferon-secreting CD4+ and CD8+ T cells from purified protein derivative-positive individuals and affords protection in a guinea pig model
    • 10.1128/IAI.71.4.1929-1937.2003, 152084, 12654810
    • Kumar P, Amara RR, Challu VK, Chadda VK, Satchidanandam V. The Apa protein of Mycobacterium tuberculosis stimulates gamma interferon-secreting CD4+ and CD8+ T cells from purified protein derivative-positive individuals and affords protection in a guinea pig model. Infect Immun 2003, 71:1929-1937. 10.1128/IAI.71.4.1929-1937.2003, 152084, 12654810.
    • (2003) Infect Immun , vol.71 , pp. 1929-1937
    • Kumar, P.1    Amara, R.R.2    Challu, V.K.3    Chadda, V.K.4    Satchidanandam, V.5
  • 10
    • 0029154710 scopus 로고
    • Evidence for glycosylation sites on the 45-Kilodalton glycoprotein of Mycobacteria tuberculosis
    • 173386, 7622204
    • Dobos K, Swiderek K, Khoo K, Brennan PJ, Belisle JT. Evidence for glycosylation sites on the 45-Kilodalton glycoprotein of Mycobacteria tuberculosis. Infect Immun 1995, 63:2846-2853. 173386, 7622204.
    • (1995) Infect Immun , vol.63 , pp. 2846-2853
    • Dobos, K.1    Swiderek, K.2    Khoo, K.3    Brennan, P.J.4    Belisle, J.T.5
  • 11
    • 0029965091 scopus 로고    scopus 로고
    • Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis
    • 177971, 8626314
    • Dobos K, Khoo K, Swiderek K, Brennan P, Belisle J. Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis. J Bacteriol 1996, 178:2498-2506. 177971, 8626314.
    • (1996) J Bacteriol , vol.178 , pp. 2498-2506
    • Dobos, K.1    Khoo, K.2    Swiderek, K.3    Brennan, P.4    Belisle, J.5
  • 12
    • 0028900798 scopus 로고
    • Antigenic and structural similarities between Mycobacterium tuberculosis 50- to 55-kilodalton and Mycobacterium bovis BCG 45- to 47-kilodalton antigens
    • 173035, 7822025
    • Espitia C, Espinosa R, Saavedra R, Mancilla R, Romain F, Laqueyrerie A, Moreno C. Antigenic and structural similarities between Mycobacterium tuberculosis 50- to 55-kilodalton and Mycobacterium bovis BCG 45- to 47-kilodalton antigens. Infect Immun 1995, 63:580-584. 173035, 7822025.
    • (1995) Infect Immun , vol.63 , pp. 580-584
    • Espitia, C.1    Espinosa, R.2    Saavedra, R.3    Mancilla, R.4    Romain, F.5    Laqueyrerie, A.6    Moreno, C.7
  • 13
    • 34247162754 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A
    • Ragas A, Roussel L, Puzo G, Riviere M. The Mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A. J Biol Chem 2007, 282:5133-5142.
    • (2007) J Biol Chem , vol.282 , pp. 5133-5142
    • Ragas, A.1    Roussel, L.2    Puzo, G.3    Riviere, M.4
  • 14
    • 0033527568 scopus 로고    scopus 로고
    • Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern
    • 10.1074/jbc.274.45.32023, 10542234
    • Horn C, Namane A, Pescher P, Riviere M, Romain F, Puzo G, Barzu O, Marchal G. Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern. J Biol Chem 1999, 274:32023-32030. 10.1074/jbc.274.45.32023, 10542234.
    • (1999) J Biol Chem , vol.274 , pp. 32023-32030
    • Horn, C.1    Namane, A.2    Pescher, P.3    Riviere, M.4    Romain, F.5    Puzo, G.6    Barzu, O.7    Marchal, G.8
  • 15
    • 2342565753 scopus 로고    scopus 로고
    • Expression, secretion, and glycosylation of the 45- and 47-kDa glycoprotein of Mycobacterium tuberculosis in Streptomyces lividans
    • 10.1128/AEM.70.2.679-685.2004, 348798, 14766542
    • Lara M, Servin-Gonzalez L, Singh M, Moreno C, Cohen I, Nimtz M, Espitia C. Expression, secretion, and glycosylation of the 45- and 47-kDa glycoprotein of Mycobacterium tuberculosis in Streptomyces lividans. Appl Environ Microbiol 2004, 70:679-685. 10.1128/AEM.70.2.679-685.2004, 348798, 14766542.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 679-685
    • Lara, M.1    Servin-Gonzalez, L.2    Singh, M.3    Moreno, C.4    Cohen, I.5    Nimtz, M.6    Espitia, C.7
  • 16
    • 0024758208 scopus 로고
    • Proteolytic enzymes from recombinant Streptomyces lividans TK24
    • Aretz W, Koller KP, Riess G. Proteolytic enzymes from recombinant Streptomyces lividans TK24. FEMS Microbiol Lett 1989, 53:31-35.
    • (1989) FEMS Microbiol Lett , vol.53 , pp. 31-35
    • Aretz, W.1    Koller, K.P.2    Riess, G.3
  • 17
    • 0026490813 scopus 로고
    • Streptomyces lividans glycosylates an exoglucanase (Cex) from Cellulomonas fimi
    • 10.1016/0378-1119(92)90173-M, 1427088
    • MacLeod AM, Gilkes NR, Escote-Carlson L, Warren RA, Kilburn DG, Miller RC. Streptomyces lividans glycosylates an exoglucanase (Cex) from Cellulomonas fimi. Gene 1992, 121:143-147. 10.1016/0378-1119(92)90173-M, 1427088.
    • (1992) Gene , vol.121 , pp. 143-147
    • MacLeod, A.M.1    Gilkes, N.R.2    Escote-Carlson, L.3    Warren, R.A.4    Kilburn, D.G.5    Miller, R.C.6
  • 18
    • 0028144157 scopus 로고
    • Streptomyces lividans glycosylates the linker region of a beta-1,4-glycanase from Cellulomonas fimi
    • 205150, 8106343
    • Ong E, Kilburn DG, Miller RC, Warren RA. Streptomyces lividans glycosylates the linker region of a beta-1,4-glycanase from Cellulomonas fimi. J Bacteriol 1994, 176:999-1008. 205150, 8106343.
    • (1994) J Bacteriol , vol.176 , pp. 999-1008
    • Ong, E.1    Kilburn, D.G.2    Miller, R.C.3    Warren, R.A.4
  • 19
    • 4444318577 scopus 로고    scopus 로고
    • Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans
    • 10.1099/mic.0.27138-0, 15289572
    • Zirkle R, Ligon JM, Molnar I. Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans. Microbiology 2004, 150:2761-2774. 10.1099/mic.0.27138-0, 15289572.
    • (2004) Microbiology , vol.150 , pp. 2761-2774
    • Zirkle, R.1    Ligon, J.M.2    Molnar, I.3
  • 21
    • 34547764371 scopus 로고    scopus 로고
    • Recombinant production of Streptococcus equisimilis streptokinase by Streptomyces lividans
    • 10.1186/1475-2859-6-20, 1936427, 17610745
    • Pimienta E, Ayala JC, Rodriguez C, Ramos A, Van ML, Vallin C, Anne J. Recombinant production of Streptococcus equisimilis streptokinase by Streptomyces lividans. Microb Cell Fact 2007, 6:20. 10.1186/1475-2859-6-20, 1936427, 17610745.
    • (2007) Microb Cell Fact , vol.6 , pp. 20
    • Pimienta, E.1    Ayala, J.C.2    Rodriguez, C.3    Ramos, A.4    Van, M.L.5    Vallin, C.6    Anne, J.7
  • 22
    • 77953204509 scopus 로고    scopus 로고
    • Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracellular medium
    • 10.1186/1475-2859-9-44, 2893106, 20534129
    • Giardina A, Alduina R, Gottardi E, Di CV, Sussmuth RD, Puglia AM. Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracellular medium. Microb Cell Fact 2010, 9:44. 10.1186/1475-2859-9-44, 2893106, 20534129.
    • (2010) Microb Cell Fact , vol.9 , pp. 44
    • Giardina, A.1    Alduina, R.2    Gottardi, E.3    Di, C.V.4    Sussmuth, R.D.5    Puglia, A.M.6
  • 23
    • 71549138788 scopus 로고    scopus 로고
    • Mycobacterium versus Streptomyces--we are different, we are the same
    • 10.1016/j.mib.2009.10.003, 19880345
    • Scherr N, Nguyen L. Mycobacterium versus Streptomyces--we are different, we are the same. Curr Opin Microbiol 2009, 12:699-707. 10.1016/j.mib.2009.10.003, 19880345.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 699-707
    • Scherr, N.1    Nguyen, L.2
  • 25
    • 0035108591 scopus 로고    scopus 로고
    • Introduction to advantages and problems of shaken cultures
    • 10.1016/S1369-703X(00)00106-6, 11173295
    • Büchs J. Introduction to advantages and problems of shaken cultures. Biochemical Engineering Journal 2001, 7:91-98. 10.1016/S1369-703X(00)00106-6, 11173295.
    • (2001) Biochemical Engineering Journal , vol.7 , pp. 91-98
    • Büchs, J.1
  • 26
    • 33746136706 scopus 로고    scopus 로고
    • Oxygen limitation is a pitfall during screening for industrial strains
    • 10.1007/s00253-006-0414-6, 16575561
    • Zimmermann HF, Anderlei T, Buchs J, Binder M. Oxygen limitation is a pitfall during screening for industrial strains. Appl Microbiol Biotechnol 2006, 72:1157-1160. 10.1007/s00253-006-0414-6, 16575561.
    • (2006) Appl Microbiol Biotechnol , vol.72 , pp. 1157-1160
    • Zimmermann, H.F.1    Anderlei, T.2    Buchs, J.3    Binder, M.4
  • 27
    • 0141961573 scopus 로고    scopus 로고
    • A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor
    • 10.1002/bit.10740, 12968289
    • Gupta A, Rao G. A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor. Biotechnol Bioeng 2003, 84:351-358. 10.1002/bit.10740, 12968289.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 351-358
    • Gupta, A.1    Rao, G.2
  • 28
    • 4043119663 scopus 로고    scopus 로고
    • Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures
    • 10.1021/bp034282t, 15296430
    • Losen M, Frolich B, Pohl M, Buchs J. Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures. Biotechnol Prog 2004, 20:1062-1068. 10.1021/bp034282t, 15296430.
    • (2004) Biotechnol Prog , vol.20 , pp. 1062-1068
    • Losen, M.1    Frolich, B.2    Pohl, M.3    Buchs, J.4
  • 29
    • 33947581606 scopus 로고    scopus 로고
    • Calculating liquid distribution in shake flasks on rotary shakers at waterlike viscosities
    • Büchs J, Maier U, Lotter S, Peter CP. Calculating liquid distribution in shake flasks on rotary shakers at waterlike viscosities. Biochemical Engineering Journal 2007, 34:200-208.
    • (2007) Biochemical Engineering Journal , vol.34 , pp. 200-208
    • Büchs, J.1    Maier, U.2    Lotter, S.3    Peter, C.P.4
  • 31
    • 0022525586 scopus 로고
    • Cloning and expression of Mycobacterium bovis BCG DNA in "Streptomyces lividans"
    • 213421, 3020007
    • Kieser T, Moss MT, Dale JW, Hopwood DA. Cloning and expression of Mycobacterium bovis BCG DNA in "Streptomyces lividans". J Bacteriol 1986, 168:72-80. 213421, 3020007.
    • (1986) J Bacteriol , vol.168 , pp. 72-80
    • Kieser, T.1    Moss, M.T.2    Dale, J.W.3    Hopwood, D.A.4
  • 32
    • 0003869903 scopus 로고    scopus 로고
    • Practical Streptomyces Genetics. John Innes Foundation, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom
    • Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA. Practical Streptomyces Genetics. John Innes Foundation, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom. 2000,
    • (2000)
    • Kieser, T.1    Bibb, M.J.2    Buttner, M.J.3    Chater, K.F.4    Hopwood, D.A.5
  • 33
    • 75849120825 scopus 로고    scopus 로고
    • Heterologous production of streptokinase as a secretary form in Streptomyces lividans and nonsecretary form in Escherichia coli
    • Kim MR, Choeng YH, Chi WJ, Kang DK, Hong SK. Heterologous production of streptokinase as a secretary form in Streptomyces lividans and nonsecretary form in Escherichia coli. J Microbiol Biotechnol 2010, 20:132-137.
    • (2010) J Microbiol Biotechnol , vol.20 , pp. 132-137
    • Kim, M.R.1    Choeng, Y.H.2    Chi, W.J.3    Kang, D.K.4    Hong, S.K.5
  • 34
    • 7044232898 scopus 로고    scopus 로고
    • Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
    • %20, 10.1002/bit.20232, 15449295
    • Serrato JA, Palomares LA, Meneses-Acosta A, Ramirez OT. Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures. Biotechnol Bioeng 2004, 88:176-188. %20, 10.1002/bit.20232, 15449295.
    • (2004) Biotechnol Bioeng , vol.88 , pp. 176-188
    • Serrato, J.A.1    Palomares, L.A.2    Meneses-Acosta, A.3    Ramirez, O.T.4
  • 35
    • 48649107131 scopus 로고    scopus 로고
    • The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
    • 10.1002/bit.21853, 2646593, 18553404
    • Nam JH, Zhang F, Ermonval M, Linhardt RJ, Sharfstein ST. The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells. Biotechnol Bioeng 2008, 100:1178-1192. 10.1002/bit.21853, 2646593, 18553404.
    • (2008) Biotechnol Bioeng , vol.100 , pp. 1178-1192
    • Nam, J.H.1    Zhang, F.2    Ermonval, M.3    Linhardt, R.J.4    Sharfstein, S.T.5
  • 36
    • 68149141804 scopus 로고    scopus 로고
    • Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells
    • 10.1002/bit.22348, 19418565
    • Gawlitzek M, Estacio M, Furch T, Kiss R. Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells. Biotechnol Bioeng 2009, 103:1164-1175. 10.1002/bit.22348, 19418565.
    • (2009) Biotechnol Bioeng , vol.103 , pp. 1164-1175
    • Gawlitzek, M.1    Estacio, M.2    Furch, T.3    Kiss, R.4
  • 37
    • 80051798475 scopus 로고    scopus 로고
    • Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform
    • Pacis E, Yu M, Autsen J, Bayer R, Li F. Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform. Biotechnol Bioeng 2011,
    • (2011) Biotechnol Bioeng
    • Pacis, E.1    Yu, M.2    Autsen, J.3    Bayer, R.4    Li, F.5
  • 39
    • 0342748564 scopus 로고    scopus 로고
    • Power consumption in shaking flasks on rotary shaking machines: II. Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity
    • 10.1002/(SICI)1097-0290(20000620)68:6<594::AID-BIT2>3.0.CO;2-U, 10799984
    • Buchs J, Maier U, Milbradt C, Zoels B. Power consumption in shaking flasks on rotary shaking machines: II. Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol Bioeng 2000, 68:594-601. 10.1002/(SICI)1097-0290(20000620)68:6<594::AID-BIT2>3.0.CO;2-U, 10799984.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 594-601
    • Buchs, J.1    Maier, U.2    Milbradt, C.3    Zoels, B.4
  • 40
    • 0342265153 scopus 로고    scopus 로고
    • Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity
    • 10.1002/(SICI)1097-0290(20000620)68:6<589::AID-BIT1>3.0.CO;2-J, 10799983
    • Buchs J, Maier U, Milbradt C, Zoels B. Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity. Biotechnol Bioeng 2000, 68:589-593. 10.1002/(SICI)1097-0290(20000620)68:6<589::AID-BIT1>3.0.CO;2-J, 10799983.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 589-593
    • Buchs, J.1    Maier, U.2    Milbradt, C.3    Zoels, B.4
  • 42
    • 1042263304 scopus 로고    scopus 로고
    • Advances in understanding and modeling the gas-liquid mass transfer in shake flasks
    • Maier U, Losen M, Buchs J. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochemical Engineering Journal 2004, 17:155-167.
    • (2004) Biochemical Engineering Journal , vol.17 , pp. 155-167
    • Maier, U.1    Losen, M.2    Buchs, J.3
  • 43
    • 33748420941 scopus 로고    scopus 로고
    • Closure effects on oxygen transfer and aerobic growth in shake flasks
    • 10.1002/bit.20930, 16607655
    • Nikakhtari H, Hill GA. Closure effects on oxygen transfer and aerobic growth in shake flasks. Biotechnol Bioeng 2006, 95:15-21. 10.1002/bit.20930, 16607655.
    • (2006) Biotechnol Bioeng , vol.95 , pp. 15-21
    • Nikakhtari, H.1    Hill, G.A.2
  • 44
    • 0032549163 scopus 로고    scopus 로고
    • Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation
    • 10.1002/(SICI)1097-0290(19980220)57:4<409::AID-BIT4>3.0.CO;2-Q, 10099217
    • Cui YQ, van der Lans RG, Luyben KC. Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation. Biotechnol Bioeng 1998, 57:409-419. 10.1002/(SICI)1097-0290(19980220)57:4<409::AID-BIT4>3.0.CO;2-Q, 10099217.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 409-419
    • Cui, Y.Q.1    van der Lans, R.G.2    Luyben, K.C.3
  • 45
    • 45749097108 scopus 로고    scopus 로고
    • Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolor
    • 10.1128/AEM.02715-07, 2446541, 18441105
    • Manteca A, Alvarez R, Salazar N, Yague P, Sanchez J. Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolor. Appl Environ Microbiol 2008, 74:3877-3886. 10.1128/AEM.02715-07, 2446541, 18441105.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 3877-3886
    • Manteca, A.1    Alvarez, R.2    Salazar, N.3    Yague, P.4    Sanchez, J.5
  • 47
    • 79851488185 scopus 로고    scopus 로고
    • Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-gamma in mild operating conditions
    • 10.1002/btpr.503, 21312365
    • Clincke MF, Guedon E, Yen FT, Ogier V, Roitel O, Goergen JL. Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-gamma in mild operating conditions. Biotechnol Prog 2011, 27:181-190. 10.1002/btpr.503, 21312365.
    • (2011) Biotechnol Prog , vol.27 , pp. 181-190
    • Clincke, M.F.1    Guedon, E.2    Yen, F.T.3    Ogier, V.4    Roitel, O.5    Goergen, J.L.6
  • 48
    • 0030590649 scopus 로고    scopus 로고
    • Characterization of murine monoclonal antibodies specific for the 45/47 kDa antigen complex (APA) of Mycobacterium tuberculosis, M. bovis and BCG
    • 10.1016/0022-1759(96)00141-X, 8890902
    • Horn C, Pescher P, Romain F, Marchal G. Characterization of murine monoclonal antibodies specific for the 45/47 kDa antigen complex (APA) of Mycobacterium tuberculosis, M. bovis and BCG. J Immunol Methods 1996, 197:151-159. 10.1016/0022-1759(96)00141-X, 8890902.
    • (1996) J Immunol Methods , vol.197 , pp. 151-159
    • Horn, C.1    Pescher, P.2    Romain, F.3    Marchal, G.4
  • 49
    • 12444336897 scopus 로고    scopus 로고
    • Oil and air dispersion in a simulated fermentation broth as a function of mycelial morphology
    • 10.1021/bp020118e, 12675561
    • Lucatero S, Larralde-Corona CP, Corkidi G, Galindo E. Oil and air dispersion in a simulated fermentation broth as a function of mycelial morphology. Biotechnol Prog 2003, 19:285-292. 10.1021/bp020118e, 12675561.
    • (2003) Biotechnol Prog , vol.19 , pp. 285-292
    • Lucatero, S.1    Larralde-Corona, C.P.2    Corkidi, G.3    Galindo, E.4
  • 50
    • 0037022420 scopus 로고    scopus 로고
    • Characterization of Azotobacter vinelandii aggregation in submerged culture by digital image analysis
    • Peña C, Reyes C, Larralde-Corona P, Corkidi G, Galindo E. Characterization of Azotobacter vinelandii aggregation in submerged culture by digital image analysis. FEMS Microbiol Lett 2002, 207:173-177.
    • (2002) FEMS Microbiol Lett , vol.207 , pp. 173-177
    • Peña, C.1    Reyes, C.2    Larralde-Corona, P.3    Corkidi, G.4    Galindo, E.5


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