Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

Genome Biology

Volumn 12, Issue 12, 2011, Pages

  Garcia, Ana M ^a   Salomon, Robert N ^b   Witsell, Alice ^c   Liepkalns, Justine ^c   Calder, R Brent ^d   Lee, Moonsook ^d   Lundell, Martha ^a   Vijg, Jan ^d   McVey, Mitch ^c  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c TUFTS UNIVERSITY   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME HELICASE; DNA LIGASE 4; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG; BLM PROTEIN, DROSOPHILA; HELICASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP);

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLM GENE; BLOOM SYNDROME; CARCINOGENESIS; CONTROLLED STUDY; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; DROSOPHILA MELANOGASTER; FEMALE; GENE LOSS; GENE REARRANGEMENT; GENOMIC INSTABILITY; LIFESPAN; MALE; MUTAGENESIS; MUTATOR GENE; NONHUMAN; SEQUENCE ANALYSIS; WILD TYPE; ANIMAL; CELL TRANSFORMATION; DNA REPAIR; GENETICS; LACTOSE OPERON; MUTATION; REPORTER GENE;

DROSOPHILA MELANOGASTER; METAZOA; MUS;

AGING; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA LIGASES; DNA REPAIR; DROSOPHILA MELANOGASTER; GENES, REPORTER; GENOMIC INSTABILITY; LAC OPERON; MUTATION;

EID: 83655182280     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2011-12-12-r121     Document Type: Article

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