End-joining repair of double-strand breaks in Drosophila melanogasters is largely DNA ligase IV independent

Genetics

Volumn 168, Issue 4, 2004, Pages 2067-2076

  McVey, Mith ^a   Radut, Dora ^a   Sekelsky, Jeff J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; DNA BINDING; DNA REPAIR; DNA STRAND BREAKAGE; DROSOPHILA MELANOGASTER; EVOLUTIONARY HOMOLOGY; FERTILITY; GENE; HOMOLOGOUS RECOMBINATION; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; SPN A GENE; SURVIVAL RATE; SYNTHESIS DEPENDENT STRAND ANNEALING;

ANIMALS; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DROSOPHILA MELANOGASTER; MUTATION;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 11244353329     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.033902     Document Type: Article

References (41)

1. ADAMS, M. D., M. MCVEY and J. J. SEKELSKY, 2003 Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 299: 265-267.
2. BARNES, D. E., G. STAMP, I. ROSEWELL, A. DENZEL and T. LINDAHL, 1998 Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 8: 1395-1398.
3. BEALL, E. L., and D. C. Rio, 1997 Drosophila P-element transposase is a novel site-specific endonuclease. Genes Dev. 11: 2137-2151.
4. BOULTON, S. J., and S. P. JACKSON, 1996 Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24: 4639-4648.
5. BOULTON, S. J., and S. P. JACKSON, 1998 Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17: 1819-1828.
6. FLYBASE, 2001 FlyBase-a database of the Drosophila genome (http://flybase.bio.indiana.edu).
7. FRANK, K. M., N. E. SHARPLESS, Y. GAO, J. M. SEKIGUCHI, D. O. FERGUSON et al., 2000 DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5: 993-1002.
8. GLOOR, G. B., C. R. PRESTON, D. M. JOHNSON-SCHLITZ, N. A. NASSIF, R. W. PHILLIS et al., 1993 Type I repressors of P element mobility. Genetics 135: 81-95.
9. GORSKI, M. M.,J. C. EEKEN, A. W. DE JONG, I. KLINK, M. LOOS et al., 2003 The Drosophila melanogaster DNA ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics 165: 1929-1941.
10. GRAWUNDER, U., D. ZIMMER, S. FUGMANN, K. SCHWARZ and M. R. LIEBER, 1998 DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2: 477-484.
11. JACKSON, S. P., 2002 Sensing and repairing DNA double-strand breaks. Carcinogenesis 23: 687-696.
12. JAGER, U., S. BOCSKOR, T. LE, G. MITTERBAUER, I. BOLZ et al., 2000 Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. Blood 95: 3520-3529.
13. KABOTYANSKI, E. B., L. GOMELSKY, J. O. HAN, T. D. STAMATO and D. B. ROTH, 1998 Double-strand break repair in Ku86- and XRCC4-deficient cells. Nucleic Acids Res. 26: 5333-5342.
14. KHANNA, K. K., and S. P. JACKSON, 2001 DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27: 247-254.
15. KURKULOS, M., J. M. WEINBERG, D. ROY and S. M. MOUNT, 1994 P element-mediated in vivo deletion analysis of white-apricot: deletions between direct repeats are strongly favored. Genetics 136: 1001-1011.
16. LEE, J. W., S. M. YANNONE, D. J. CHEN and L. F. POVIRK, 2003 Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA endjoining in vitro. Cancer Res. 63: 22-24.
17. LIEBER, M. R., Y. MA, U. PANNICKE and K. SCHWARZ, 2003 Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4: 712-720.
18. MA, J. L., E. M. KIM, J. E. HABER and S. E. LEE, 2003 Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell. Biol. 23: 8820-8828.
19. MAHAJAN, K. N., S. A. NICK MCELHINNY, B. S. MITCHELL and D. A. RAMSDEN, 2002 Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol. Cell. Biol. 22: 5194-5202.
20. MCILWRAITH, M. J., E. VAN DYCK, J. Y. MASSON, A. Z. STASIAK, A. STASIAK et al., 2000 Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins. J. Mol. Biol. 304: 151-164.
21. MCVEY, M., M. D. ADAMS, E. STAEVA-VIEIRA and J. J. SEKELSKY, 2004 Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila. Genetics 167: 699-705.
22. MILNE, G. T., S. JIN, K. B. SHANNON and D. T. WEAVER, 1996 Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16: 4189-4198.
23. NASSIF, N., J. PENNEY, S. PAL, W. R. ENGELS and G. B. GLOOR, 1994 Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Mol. Cell. Biol. 14: 1613-1625.
24. PÂQUES, F., W.-Y. LEUNG and J. E. HABER, 1998 Expansions and contractions in a tandem repeat caused by double-strand break repair. Mol. Cell. Biol. 18: 2045-2054.
25. RICH, T., R. L. ALLEN and A. H. WYLLIE, 2000 Defying death after DNA damage. Nature 407: 777-783.
26. SEKELSKY, J. J., M. H. BRODSKY and K. C. BURTIS, 2000 DNA repair in Drosophila: insights from the Drosophila genome sequence. J. Cell Biol. 150: F31-F36.
27. SIBANDA, B. L., S. E. CRITCHLOW, J. BEGUN, X. Y. PEI, S. P. JACKSON et al., 2001 Crystal structure of an Xrcc4-D NA ligase IV complex. Nat. Struct. Biol. 8: 1015-1019.
28. SMITH, J., E. RIBALLO, B. KYSELA, C. BALDEYRON, K. MANOLIS et al., 2003 Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res. 31: 2157-2167.
29. STAEVA-VIEIRA, E., S. YOO and R. LEHMANN, 2003 An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control. EMBO J. 22: 5863-5874.
30. TEO, S. H., and S. P. JACKSON, 1997 Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J. 16: 4788-4795.
31. TEO, S. H., and S. P. JACKSON, 2000 Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr. Biol. 10: 165-168.
32. TSENG, H. M., and A. E. TOMKINSON, 2002 A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. J. Biol. Chem. 277: 45630-45637.
33. VAN ATTIKUM, H., P. BUNDOCK, R. M. OVERMEER, L. Y. LEE, S. B. GELVIN et al., 2003 The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA. Nucleic Acids Res. 31: 4247-4255.
34. VAN DEN BOSCH, M., P. H. LOHMAN and A. PASTINK, 2002 DNA double-strand break repair by homologous recombination. Biol. Chem. 383: 873-892.
35. VERKAIK, N. S., R. E. ESVELDT-VAN LANGE, D. VAN HEEMST, H. T. BRUGGENWIRTH, J. H. HOEIJMAKERS et al., 2002 Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur. J. Immunol. 32: 701-709.
36. WANG, H., A. R. PERRAULT, Y. TAKEDA, W. QIN and G. ILIAKIS, 2003 Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 31: 5377-5388.
37. WEST, S. C., 2003 Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell Biol. 4: 435-445.
38. WILSON, T. E., and M. R. LIEBER, 1999 Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway. J. Biol. Chem. 274: 23599-23609.
39. WILSON, T. E., U. GRAWUNDER and M. R. LIEBER, 1997 Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388: 495-498.
40. YOSHIDA, H., T. NAOE, H. FUKUTANI, H. KIYOI, K. KUBO et al., 1995 Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia: sequence non-specific recombination between the PML and RARA genes within identical short stretches. Genes Chromosomes Cancer 12: 37-44.
41. Yu, X., and A. GABRIEL, 2003 Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae. Genetics 163: 843-856.