Size control of chitosan capsules containing insulin for oral drug delivery via a combined process of ionic gelation with electrohydrodynamic atomization

Industrial and Engineering Chemistry Research

Volumn 50, Issue 24, 2011, Pages 13762-13770

  Kim, Sang Yoon ^a   Lee, Hyunah ^a   Cho, Sungyeon ^a   Park, Ji Woon ^a   Park, Jiyong ^a   Hwang, Jungho ^a  

^a Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; CHITOSAN CAPSULES; COMBINED PROCESS; ELECTROHYDRODYNAMIC ATOMIZATION; ENCAPSULATION EFFICIENCY; IN-VITRO TESTS; INSULIN DELIVERY; INSULIN RELEASE; IONIC GELATION METHOD; MEAN DIAMETER; ORAL DRUG DELIVERY; PHYTIC ACIDS; SIZE CONTROL;

ATOMIZATION; CHITOSAN; COAGULATION; DROPS; DRUG DELIVERY; ELECTROHYDRODYNAMICS; GELATION; INSULIN; SPRAY NOZZLES;

ENCAPSULATION;

EID: 83655164461     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie200915x     Document Type: Article

References (47)

1. Gholamipour-Shirazi, A. Insulin encapsulation Expert Opin. Drug Delivery 2008, 5, 1335
2. Carino, G. P.; Mathiowitz, E. Oral insulin delivery Adv. Drug Delivery Rev. 1999, 35, 249
3. des Rieux, A.; Fievez, V.; Garinot, M. Nanoparticles as potential oral delivery systems for proteins and vaccines: A mechanistic approach J. Controlled Release 2006, 116, 1
4. Silva, G. A.; Ducheyne, P.; Reis, R. L. Material in particulate form for tissue engineering J. Tissue Eng. Regen. Med. 2007, 1, 4
5. Pancholi, K.; Ahras, N.; Stride, E.; Edirisinghe, M. Novel electrohydrodynamic preparation of porous chitosan particles for durg delivery J. Mater. Sci. 2009, 20, 917
6. Denkbas, E. B.; Seyyal, M.; Piskin, E. 5-Fluorouracil loaded chitosan microspheres for chemoembolization J. Microencap. 1998, 16, 741
7. Sankar, C.; Rani, M.; Srivastava, A. K.; Mishra, B. Chitosan based pentazocine microspheres for intranasal systemic delivery: Development and biopharmaceutical evaluation Pharmazie 2001, 56, 223
8. Jameela, S. R.; Kumary, T. V.; Lal, A. V.; Jayakrishnan, A. Progesterone-loaded chitosan microspheres: A long acting biodegradable controlled delivery system J. Controlled Release 1998, 52, 17
9. Berthod, A.; Kreuter, J. Chitosan microspheres-improved acid stability and change in physicochemical properties by cross-linking Proc. Int. Symp. Control Rel. Bioact. Mater. 1996, 23, 369
10. Turan, S. O.; Akbuga, J.; Aral, C. Controlled release of interleukin-2 from chitosan microspheres J. Pharm. Sci. 2002, 91, 124
11. Mao, H. Q.; Roy, K.; Le, V. L.; Janes, K. A.; Kim, K. Y.; Wang, Y.; August, J. T.; Leong, K. W. Chitosan DNA nanoparticles as gene delivery carriers: Synthesis, characterization and transfection efficiency J. Controlled Release 2001, 70, 399
12. He, P.; Davis, S. S.; Illum, L. Chitosan microspheres prepared by spray drying Int. J. Pharm. 1999, 187, 53
13. Conti, B.; Modena, T.; Genta, I.; Perugini, P.; Decarro, C.; Pavanetto, F. Microencapsulation of cetylpyridinium chloride with a bioadhesive polymer Proc. Int. Symp. Control Rel. Bioact. Mater. 1998, 25, 822
14. Huang, C.; Yeh, M. K.; Chiang, C. H. Formulation factors in preparing BTM-chitosan microspheres by spray drying method Int. J. Pharm. 2002, 242, 239
15. Shi, X. Y.; Tan, T. W. Preparation of chitosan/ethlcellulose complex microcapsule and its application in controlled release of vitamin D-2 Biomaterials 2002, 23, 4469
16. Shu, X. Z.; Zhu, K. J. Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation J. Microencap. 2001, 18, 237
17. Mi, F. L.; Sung, H. W.; Shu, S. S. Release of indomethacin from a novel chitosan microsphere prepared by naturally occurring crosslinker: Examination of crosslinking and polycation/anion drug interaction J. Appl. Polym. Sci. 2001, 81, 1700
18. Ko, J. A.; Park, H. J.; Hwang, S. J.; Park, J. B.; Lee, J. S. Preparation and characterization of chitosan microparticles intended for controlled drug delivery Int. J. Pharm. 2002, 249, 165
19. Calvo, P.; Lopez, C. R.; Jata, J. L.; Alonso, M. J. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers J. Appl. Polym. Sci. 1997, 63, 125
20. Shu, X. Z.; Zhu, K. J. A novel approach to prepare tripolyphosphate/ chitosan complex beads for controlled release drug delivery Int. J. Pharm. 2000, 201, 51
21. Urrusuno, R. F.; Cavlo, P.; Lopez, C. R.; Jato, J. L.; Alonso, M. J. Enhancement of nasal absorption of insulin using chitosan nanoparticles Pharm. Res. 1999, 16, 1576
22. Pan, Y.; Li, Y.; Zhao, H.; Zheng, J.; Xu, H.; Wei, G.; Cui, F. Chitosan nanoparticles improve the intestinal absorption of insulin in vivo Int. J. Pharm. 2002, 249, 139
23. Wu, L. Q.; Gadre, A. P.; Yi, H.; Kastantin, M. J.; Rubloff, G. W.; Bentley, W. E.; Payne, G. F.; Ghodssi, R. Voltage-dependent assembly of the polysaccharide chitosan onto an electrode surface Langmuir 2002, 18, 8620
24. Tsai, M. L.; Bai, S. W.; Chen, R. H. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan-sodium tripolyphosphate nanoparticle Carbohydr. Polym. 2008, 71, 448
25. Yang, L.; Liu, H.; Hu, N. Assembly of electroactive layer-by-layer films of myoglobin and small-molecular phytic acid Electrochem. Commun. 2007, 9, 1057
26. Heinzen, C.; Berger, A.; Marison, I. Use of vibration technology for jet break-up for encapsulation of cells, microbes and liquids in monodisperse microcapsules Landbauforsch Volkenrode 2002, 241, 19
27. Xie, J.; Wang, C. H. Electrospray in the dripping mode for cell microencapsulation J. Colloid Interface Sci. 2007, 312, 247
28. Hartman, R. P. A. Electrohydrodynamic atomization in the cone-jet mode. Ph.D. Thesis, Delft University, The Netherlands, 1998.
29. Arya, N.; Charkraborty, S.; Dube, N.; Katti, D. S. Electrospraying: A facile technique for synthesis of chitosan-based micro/nanospheres for drug delivery applications J. Biomed. Mater. Res., Part B 2009, 88, 17
30. Enayati, M.; Ahmad, Z.; Stride, E.; Edirisinghe, M. One-step electrohydrodynamic production of drug-loaded micro- and nanoparticles J. R. Soc. Interface 2010, 7, 667
31. Enayati, M.; Ahmad, Z.; Stride, E.; Edirisinghe, M. Preparation of polymeric carriers for drug delivery with different shape and size using an electric jet Current Pharm Biotechnol. 2009, 10, 600
32. Chang, M. W.; Stride, E.; Edirisinghe, M. A new method for the preparation of monoporous hollow microspheres Langmuir 2010, 26, 5115
33. Chang, M. W.; Stride, E.; Edirisinghe, M. Controlling the thickness of hollow polymeric microspheres prepared by electrohydrodynamic atomization J. R. Soc. Interface 2010, 7, S451
34. Chang, M. W.; Stride, E.; Edirisinghe A novel process for drug encapsulation using a liquid to vapour phase change material Soft Matter 2009, 5, 5029
35. Zhang, H. B.; Jayasinghe, S. N.; Edirisinghe, M. J. Electrically forced microthreading of highly viscous dielectric liquids J. Electrostat. 2006, 64, 355
36. Barrero, A.; Lopez-Herrera, J. M.; Boucard, A; Loscertales, I. G.; Marquez, M. Steady cone-jet electrosprays in liquid insulator baths J. Colloid Interface Sci. 2004, 272, 104
37. Jayasinghe, S. N.; Edirisinghe, M. J.; Wang, D. Z. Controlled deposition of nanoparticle clusters by electrohydrodynamic atomization Nanotechnology 2004, 15, 1519
38. Stachewicz, U.; Yuteri, C. U.; Dijksman, J. F.; Marijnissen, J. C. M. Single event electrospraying of water J. Aerosol Sci. 2010, 41, 963
39. Eggers, J. Nonlinear dynamics and breakup of free-surface flows Rev. Mod. Phys. 1997, 69, 865
40. Sarmento, B.; Ferreira, D.; Veiga, F.; Ribeiro, A. Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies Carbohydr. Polym. 2006, 66, 1
41. Wei, J.; Lin, Y. Z.; Zhou, J. M.; Tsou, C. L. FTIR studies of secondary structures of bovine insulin and its derivatives Biochim. Biophys. Acta 1991, 1080, 29
42. Xie, L.; Tsou, C. L. Comparison of secondary structures of insulin and proinsulin by FTIR J. Protein Chem. 1993, 12, 483
43. Dzwolak, W.; Ravindra, R.; Lendermann, J.; Winter, R. Aggregation of bovine insulin probed by DSC/PPC calorimetry and FTIR spectroscopy Biochemistry 2003, 42, 11347
44. Brange, J. Galenics of insulin: The Physic-Chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations; Springer: Berlin, 1987.
45. Rohrs, B. R.; Amidon, G. E.; Meury, R. H.; Secreast, P. J.; King, H. M.; Skoug, C. J. Particle size limits to meet USP content uniformity criteria for tablets and capsules J. Pharm. Sci. 2006, 95, 1049
46. Pan, Y.; Zheng, J. M.; Zhao, H. Y.; Li, Y. J.; Xu, H.; Wei, G. Relationship between drug effects and particle size of insulin-loaded bioadhesive microspheres Acta Pharmacol. Sin. 2002, 23, 1051
47. Dressman, J. B.; Amidon, G.; Reppas, C.; Shah, V. P. Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms Pharm. Res. 1998, 15, 11