Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP

Pharmaceutical Research

Volumn 28, Issue 12, 2011, Pages 3105-3115

  Vávrová, Kateřina ^a,d   Kovaříková, Petra ^a   Školová, Barbora ^a   Líbalová, Martina ^a   Roh, Jaroslav ^a   Čáp, Robert ^b   Holý, Antonín ^c   Hrabálek, Alexandr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

acyclic nucleoside phosphonates; antineoplastics; antivirals; permeation enhancer; topical skin application; transdermal delivery

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DODECYL 6 DIMETHYLAMINOHEXANOATE; HEXANOIC ACID; N6 CYCLOPROPYL 2,6 DIAMINO 9 [2 (PHOSPHONOMETHOXY)ETHYL]PURINE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TRANSPORT; EAR; EPIDERMIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIPOPHILICITY; MASS SPECTROMETRY; NONHUMAN; PH; PRIORITY JOURNAL; SKIN; SKIN CONDUCTANCE; SKIN FLORA; STRATUM CORNEUM; SWINE; TOPICAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION;

ADENINE; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; HEXANOIC ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; METHYLAMINES; PERMEABILITY; PHOSPHONIC ACIDS; SKIN; SWINE;

EID: 83555174468     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0508-4     Document Type: Article

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